Low‐Level Laser Therapy for Closed‐Head Traumatic Brain Injury in Mice: Effect of Different Wavelengths

Traumatic brain injury (TBI) affects millions worldwide and is without effective treatment. One area that is attracting growing interest is the use of transcranial low‐level laser therapy (LLLT) to treat TBI. The fact that near‐infrared light can penetrate into the brain would allow non‐invasive treatment to be carried out with a low likelihood of treatment‐related adverse events. LLLT may treat TBI by increasing respiration in the mitochondria, causing activation of transcription factors, reducing inflammatory mediators and oxidative stress, and inhibiting apoptosis.

[1]  M. Cusimano,et al.  Severe traumatic brain injury. , 2013, Journal of neurosurgery.

[2]  Chad J. Donahue,et al.  Low-level laser light therapy improves cognitive deficits and inhibits microglial activation after controlled cortical impact in mice. , 2012, Journal of neurotrauma.

[3]  C L Gwinnutt,et al.  Early hospital care of severe traumatic brain injury , 2011, Anaesthesia.

[4]  Minoru Obara,et al.  Comparison of Therapeutic Effects between Pulsed and Continuous Wave 810-nm Wavelength Laser Irradiation for Traumatic Brain Injury in Mice , 2011, PloS one.

[5]  N. Marklund,et al.  Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here? , 2011, British journal of pharmacology.

[6]  Michael R Hamblin,et al.  Dose response effects of 810 nm laser light on mouse primary cortical neurons , 2011, Lasers in surgery and medicine.

[7]  Michael R Hamblin,et al.  Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts , 2009, BiOS.

[8]  Andrew J MacGregor,et al.  Injury-Specific Correlates of Combat-Related Traumatic Brain Injury in Operation Iraqi Freedom , 2011, The Journal of head trauma rehabilitation.

[9]  Michael R Hamblin,et al.  Potential for transcranial laser or LED therapy to treat stroke, traumatic brain injury, and neurodegenerative disease. , 2011, Photomedicine and laser surgery.

[10]  J. Szmydynger-Chodobska,et al.  Emerging concepts in the pathophysiology of traumatic brain injury. , 2010, The Psychiatric clinics of North America.

[11]  Michael R. Hamblin,et al.  Low-Level Laser Therapy in Stroke and Central Nervous System , 2010 .

[12]  Michael R. Hamblin,et al.  Advances in Low-Intensity Laser and Phototherapy , 2010 .

[13]  B. Huisa,et al.  The Evolution of Transcranial Laser Therapy for Acute Ischemic Stroke, Including a Pooled Analysis of NEST-1 and NEST-2 , 2010, Current cardiology reports.

[14]  L. Klimaschewski,et al.  From Birth Till Death: Neurogenesis, Cell Cycle, and Neurodegeneration , 2009, Anatomical record.

[15]  S. Molitor,et al.  Effects of near‐infrared laser exposure in a cellular model of wound healing , 2009, Photodermatology, photoimmunology & photomedicine.

[16]  Marc Fisher,et al.  Effectiveness and Safety of Transcranial Laser Therapy for Acute Ischemic Stroke , 2009, Stroke.

[17]  Jackson Streeter,et al.  810 nm Wavelength light: An effective therapy for transected or contused rat spinal cord , 2009, Lasers in surgery and medicine.

[18]  T. Karu.  Mitochondrial Signaling in Mammalian Cells Activated by Red and Near‐IR Radiation , 2008, Photochemistry and photobiology.

[19]  V. Drory,et al.  Laser phototherapy (780 nm), a new modality in treatment of long-term incomplete peripheral nerve injury: a randomized double-blind placebo-controlled study. , 2007, Photomedicine and laser surgery.

[20]  Y. Lampl,et al.  Laser treatment for stroke , 2007, Expert review of neurotherapeutics.

[21]  O. Kharenko,et al.  Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure (double-blind randomized study). , 2007, Photomedicine and laser surgery.

[22]  Marc Fisher,et al.  Infrared Laser Therapy for Ischemic Stroke: A New Treatment Strategy: Results of the NeuroThera Effectiveness and Safety Trial–1 (NEST-1) , 2007, Stroke.

[23]  F. Al-Watban,et al.  Low-level laser therapy enhances wound healing in diabetic rats: a comparison of different lasers. , 2007, Photomedicine and laser surgery.

[24]  Amir Oron,et al.  low-level laser therapy applied transcranially to mice following traumatic brain injury significantly reduces long-term neurological deficits. , 2007, Journal of neurotrauma.

[25]  Jieli Chen,et al.  Low-Level Laser Therapy Applied Transcranially to Rats After Induction of Stroke Significantly Reduces Long-Term Neurological Deficits , 2006, Stroke.

[26]  Michael R. Hamblin,et al.  Mechanisms of low level light therapy , 2006, SPIE BiOS.

[27]  T. Karu,et al.  Absorption measurements of a cell monolayer relevant to phototherapy: reduction of cytochrome c oxidase under near IR radiation. , 2005, Journal of photochemistry and photobiology. B, Biology.

[28]  R. Waynant,et al.  Light promotes regeneration and functional recovery and alters the immune response after spinal cord injury , 2005, Lasers in surgery and medicine.

[29]  Britton Chance,et al.  Photobiomodulation Directly Benefits Primary Neurons Functionally Inactivated by Toxins , 2005, Journal of Biological Chemistry.

[30]  David K Menon,et al.  Traumatic brain injury: physiology, mechanisms, and outcome , 2004, Current opinion in neurology.

[31]  Luis De Taboada,et al.  Mechanisms of action of light therapy for stroke and acute myocardial infarction. , 2004, Mitochondrion.

[32]  H. Bramlett,et al.  Pathophysiology of Cerebral Ischemia and Brain Trauma: Similarities and Differences , 2004, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  W. Hauser,et al.  The Epidemiology of Traumatic Brain Injury: A Review , 2003, Epilepsia.

[34]  M. Leung,et al.  Treatment of experimentally induced transient cerebral ischemia with low energy laser inhibits nitric oxide synthase activity and up‐regulates the expression of transforming growth factor‐beta 1 , 2002, Lasers in surgery and medicine.

[35]  E. Shohami,et al.  Cerebral ischemia and trauma—different etiologies yet similar mechanisms: neuroprotective opportunities , 2002, Brain Research Reviews.

[36]  Sean M. Grady,et al.  Clinical trials in head injury. , 2002, Neurological research.

[37]  B. Albensi.  Models of brain injury and alterations in synaptic plasticity , 2001, Journal of neuroscience research.

[38]  Jean-François Richard,et al.  Methods of Numerical Integration , 2000 .

[39]  K A Dunn,et al.  Traumatic brain injury in the United States: A public health perspective. , 1999, The Journal of head trauma rehabilitation.

[40]  D. McArthur,et al.  Epidemiologic aspects of brain injury. , 1996, Neurologic clinics.

[41]  D. Thurman,et al.  Monitoring the impact of traumatic brain injury: a review and update. , 1995, Journal of neurotrauma.

[42]  S. Cotev,et al.  Experimental closed head injury in rats: mechanical, pathophysiologic, and neurologic properties. , 1988, Critical care medicine.

[43]  K. Barlow.  Traumatic brain injury. , 2013, Handbook of clinical neurology.

[44]  Da Xing,et al.  Inhibition of Aβ(25-35)-induced cell apoptosis by low-power-laser-irradiation (LPLI) through promoting Akt-dependent YAP cytoplasmic translocation. , 2012, Cellular signalling.

[45]  M. Rovegno,et al.  Biological mechanisms involved in the spread of traumatic brain damage , 2012 .

[46]  R. V. Bernhardi,et al.  [Biological mechanisms involved in the spread of traumatic brain damage]. , 2012, Medicina intensiva.

[47]  Luis De Taboada,et al.  Transcranial laser therapy attenuates amyloid-β peptide neuropathology in amyloid-β protein precursor transgenic mice. , 2011, Journal of Alzheimer's disease : JAD.

[48]  K. Kang,et al.  Effect of 980-nm GaAlAs diode laser irradiation on healing of extraction sockets in streptozotocin-induced diabetic rats: a pilot study , 2011, Lasers in Medical Science.

[49]  Nick Lane,et al.  Power games , 2006 .

[50]  J E Sniezek,et al.  Incidence of mild and moderate brain injury in the United States, 1991. , 1996, Brain injury.