“Strategic sequences” in adipose‐derived stem cell nerve regeneration

Peripheral nerve injuries (PNI) are a major source of morbidity worldwide. The development of cellular regenerative therapies has the potential to improve outcomes of nerve injuries. However, an ideal therapy has yet to be found. The purpose of this study is to examine the current literature key points of regenerative techniques using human adipose‐derived stem cells (hADSCs) for nerve regeneration and derive a comprehensive approach to hADSC therapy for PNI.

[1]  T. Blunk,et al.  Enzymatically degradable poly(ethylene glycol) based hydrogels for adipose tissue engineering. , 2010, Biomaterials.

[2]  R. Weber,et al.  A Randomized Prospective Study of Polyglycolic Acid Conduits for Digital Nerve Reconstruction in Humans , 2000, Plastic and reconstructive surgery.

[3]  M. Meek,et al.  Clinical Use of Nerve Conduits in Peripheral-Nerve Repair: Review of the Literature , 2002, Journal of reconstructive microsurgery.

[4]  G. Evans,et al.  Inducible Nerve Growth Factor Delivery for Peripheral Nerve Regeneration In Vivo , 2010, Plastic and reconstructive surgery.

[5]  Wei Tang,et al.  Ectopic adipogenesis of preconditioned adipose-derived stromal cells in an alginate system , 2007, Cell and Tissue Research.

[6]  Robert J Fisher,et al.  Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. , 2006, Biomaterials.

[7]  H. Karagoz,et al.  Vascular endothelial growth factor‐loaded poly(lactic‐co‐glycolic acid) microspheres‐induced lateral axonal sprouting into the vein graft bridging two healthy nerves: Nerve graft prefabrication using controlled release system , 2012, Microsurgery.

[8]  A. Hoekstra.  PROSPERING ON THE FAT OF THE LAND: ADIPOSE-DERIVED STEM CELLS AS AN INDUSTRIALLY-VIABLE RESOURCE FOR REGENERATIVE TREATMENT , 2011 .

[9]  Sujeong Jang,et al.  Functional neural differentiation of human adipose tissue-derived stem cells using bFGF and forskolin , 2010, BMC Cell Biology.

[10]  Doina Dimonie,et al.  Layer-shaped alginate hydrogels enhance the biological performance of human adipose-derived stem cells , 2012, BMC Biotechnology.

[11]  B. Amsden,et al.  Methacrylated glycol chitosan as a photopolymerizable biomaterial. , 2007, Biomacromolecules.

[12]  Peter X. Ma,et al.  Scaffolding In Tissue Engineering , 2005 .

[13]  D. Boyd,et al.  FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. , 2012, Injury.

[14]  E. Thompson,et al.  Host rather than graft origin of Matrigel-induced adipose tissue in the murine tissue-engineering chamber. , 2007, Tissue engineering.

[15]  S. Archibald,et al.  The effect of collagen nerve conduits filled with collagen-glycosaminoglycan matrix on peripheral motor nerve regeneration in a rat model. , 2012, The Journal of bone and joint surgery. American volume.

[16]  John W Haycock,et al.  Next generation nerve guides: materials, fabrication, growth factors, and cell delivery. , 2012, Tissue engineering. Part B, Reviews.

[17]  K. Christman,et al.  Injectable biomaterials for adipose tissue engineering , 2012, Biomedical materials.

[18]  Bai-Shuan Liu,et al.  Peripheral nerve repair of transplanted undifferentiated adipose tissue-derived stem cells in a biodegradable reinforced nerve conduit. , 2012, Journal of biomedical materials research. Part A.

[19]  S. Hsiao,et al.  Hypoxic conditioning enhances the angiogenic paracrine activity of human adipose-derived stem cells. , 2013, Stem cells and development.

[20]  Bai-Shuan Liu,et al.  Regenerative effect of adipose tissue‐derived stem cells transplantation using nerve conduit therapy on sciatic nerve injury in rats , 2014, Journal of tissue engineering and regenerative medicine.

[21]  S. Hsiao,et al.  Hypoxic preconditioning enhances survival of human adipose-derived stem cells and conditions endothelial cells in vitro. , 2012, Stem cells and development.

[22]  W. Raffoul,et al.  Long-term in vivo regeneration of peripheral nerves through bioengineered nerve grafts , 2011, Neuroscience.

[23]  J. Leong,et al.  In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute. , 2006, Biochemical and biophysical research communications.

[24]  Jung Keun Hyun,et al.  Phosphate glass fibres promote neurite outgrowth and early regeneration in a peripheral nerve injury model , 2015, Journal of tissue engineering and regenerative medicine.

[25]  Seung‐Woo Cho,et al.  Enhancement of adipose tissue formation by implantation of adipogenic-differentiated preadipocytes. , 2006, Biochemical and biophysical research communications.

[26]  Laura J Suggs,et al.  Three-dimensional culture for expansion and differentiation of mouse embryonic stem cells. , 2006, Biomaterials.

[27]  Glenn D Prestwich,et al.  Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor. , 2005, Biomaterials.

[28]  P. Blondeel,et al.  Human clinical experience with adipose precursor cells seeded on hyaluronic acid-based spongy scaffolds. , 2008, Biomaterials.

[29]  E. Eriksson.  Surgery of the Peripheral Nerve , 1990 .

[30]  Marcia Simon,et al.  Hydrogels for Regenerative Medicine , 2016 .

[31]  F. Guilak,et al.  Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells , 2010, Stem Cell Research & Therapy.

[32]  P. Pinton,et al.  Hyaluronan and Fibrin Biomaterial as Scaffolds for Neuronal Differentiation of Adult Stem Cells Derived from Adipose Tissue and Skin , 2011, International journal of molecular sciences.

[33]  Ying Wang,et al.  Adipose-derived stem cells promote peripheral nerve repair , 2011, Archives of medical science : AMS.

[34]  G. Bedogni,et al.  Human adipose-derived mesenchymal stem cells systemically injected promote peripheral nerve regeneration in the mouse model of sciatic crush. , 2012, Tissue engineering. Part A.

[35]  C. Patrick,et al.  Rheological and recovery properties of poly(ethylene glycol) diacrylate hydrogels and human adipose tissue. , 2005, Journal of biomedical materials research. Part A.

[36]  T. Walters,et al.  A bilayer construct controls adipose-derived stem cell differentiation into endothelial cells and pericytes without growth factor stimulation. , 2011, Tissue engineering. Part A.

[37]  Laura Suggs,et al.  A PEGylated fibrin patch for mesenchymal stem cell delivery. , 2006, Tissue engineering.

[38]  G. Lajoie,et al.  Matrigel: A complex protein mixture required for optimal growth of cell culture , 2010, Proteomics.

[39]  M. Wiberg,et al.  Laminin activates NF-κB in Schwann cells to enhance neurite outgrowth , 2008, Neuroscience Letters.

[40]  Huanxing Su,et al.  Nanofiber scaffolds facilitate functional regeneration of peripheral nerve injury. , 2013, Nanomedicine : nanotechnology, biology, and medicine.

[41]  M. Rosenwasser,et al.  Effect of white adipose tissue flap and insulin‐like growth factor‐1 on nerve regeneration in rats , 2013, Microsurgery.

[42]  C. Zhang,et al.  Neurospheres from rat adipose-derived stem cells could be induced into functional Schwann cell-like cells in vitro , 2008, BMC Neuroscience.

[43]  P. Gentile,et al.  Concise Review: Adipose‐Derived Stromal Vascular Fraction Cells and Platelet‐Rich Plasma: Basic and Clinical Implications for Tissue Engineering Therapies in Regenerative Surgery , 2012, Stem cells translational medicine.

[44]  K. Wewetzer,et al.  The long‐term functional recovery of repair of sciatic nerve transection with biogenic conduits , 2012, Microsurgery.

[45]  P. Tos,et al.  Primary repair of crush nerve injuries by means of biological tubulization with muscle‐vein‐combined grafts , 2012, Microsurgery.

[46]  B. Bunnell,et al.  Adipose-derived stem cells on hyaluronic acid-derived scaffold: a new horizon in bioengineered cornea. , 2012, Archives of ophthalmology.

[47]  Claire Yu,et al.  Co-delivery of adipose-derived stem cells and growth factor-loaded microspheres in RGD-grafted N-methacrylate glycol chitosan gels for focal chondral repair. , 2012, Biomacromolecules.

[48]  Renata V Weber,et al.  Processed nerve allografts for peripheral nerve reconstruction: A multicenter study of utilization and outcomes in sensory, mixed, and motor nerve reconstructions , 2012, Microsurgery.

[49]  J. Gimble,et al.  Competitive DNA transfection formulation via electroporation for human adipose stem cells and mesenchymal stem cells , 2012, Biological Procedures Online.

[50]  D. H. Kim,et al.  Transplantation of adipose derived stem cells for peripheral nerve regeneration in sciatic nerve defects of the rat. , 2012, Current stem cell research & therapy.

[51]  M. Meek,et al.  US Food and Drug Administration/Conformit Europe-Approved Absorbable Nerve Conduits for Clinical Repair of Peripheral and Cranial Nerves , 2008, Annals of plastic surgery.