Inactivation of the LKB1-AMPK signaling pathway does not contribute to salivary gland tumor development - a short report

[1]  S. Indraccolo,et al.  Manipulation of tumor metabolism for therapeutic approaches: ovarian cancer-derived cell lines as a model system , 2015, Cellular Oncology.

[2]  Sheryl K Elkin,et al.  Genomic landscape of salivary gland tumors , 2015, Oncotarget.

[3]  Philippe P Roux,et al.  The expanding role of mTOR in cancer cell growth and proliferation. , 2015, Mutagenesis.

[4]  E. E. Vincent,et al.  The AMP-activated protein kinase (AMPK) and cancer: many faces of a metabolic regulator. , 2015, Cancer letters.

[5]  N. Yoo,et al.  Somatic mutations of amino acid metabolism-related genes in gastric and colorectal cancers and their regional heterogeneity - a short report , 2014, Cellular Oncology.

[6]  N. Dimitrova,et al.  A novel saliva-based microRNA biomarker panel to detect head and neck cancers , 2014, Cellular Oncology.

[7]  H. Konishi,et al.  Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells , 2014, Cellular Oncology.

[8]  M. Castelo‐Branco,et al.  Genetic gains and losses in oral squamous cell carcinoma: impact on clinical management , 2014, Cellular Oncology.

[9]  D. Hayes,et al.  The LKB1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues , 2013, PloS one.

[10]  N. Ghahhari,et al.  Could a Possible Crosstalk between AMPK and TGF-β Signaling Pathways Be a Key Player in Benign and Malignant Salivary Gland Tumors? , 2012, Oncology Research and Treatment.

[11]  M. Krahn,et al.  Drosophila PATJ supports adherens junction stability by modulating Myosin light chain activity , 2012, The Journal of cell biology.

[12]  T. Ettl,et al.  The PI3K/AKT/mTOR signalling pathway is active in salivary gland cancer and implies different functions and prognoses depending on cell localisation. , 2012, Oral oncology.

[13]  Xin Lu,et al.  Epithelial cell polarity: a major gatekeeper against cancer? , 2011, Cell Death and Differentiation.

[14]  T. Mäkelä,et al.  Molecular mechanisms of tumor suppression by LKB1 , 2011, FEBS letters.

[15]  Gerd Walz,et al.  Primary cilia regulate mTORC1 activity and cell size through Lkb1 , 2010, Nature Cell Biology.

[16]  H. Ji,et al.  Spectrum of LKB1, EGFR, and KRAS Mutations in Chinese Lung Adenocarcinomas , 2010, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[17]  Chin-Lee Wu,et al.  mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome , 2009, Proceedings of the National Academy of Sciences.

[18]  Kwok-Kin Wong,et al.  Somatic LKB1 Mutations Promote Cervical Cancer Progression , 2009, PloS one.

[19]  M. Meyerson,et al.  Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients , 2008, British Journal of Cancer.

[20]  B. Turk,et al.  AMPK phosphorylation of raptor mediates a metabolic checkpoint. , 2008, Molecular cell.

[21]  I. Macara,et al.  STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7. , 2008, Molecular biology of the cell.

[22]  Kwok-Kin Wong,et al.  Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. , 2008, Cancer research.

[23]  M. Sanchez-Cespedes.  A role for LKB1 gene in human cancer beyond the Peutz–Jeghers syndrome , 2007, Oncogene.

[24]  D. Neil Hayes,et al.  LKB1 modulates lung cancer differentiation and metastasis , 2007, Nature.

[25]  David M Sabatini,et al.  Defining the role of mTOR in cancer. , 2007, Cancer cell.

[26]  S. Berger,et al.  LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. , 2006, Cancer research.

[27]  L. Thompson,et al.  World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours , 2006, Ear, nose, & throat journal.

[28]  R. DePinho,et al.  The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin , 2005, Science.

[29]  A. Reymond,et al.  LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. , 2005, Human molecular genetics.

[30]  Hans Clevers,et al.  Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. , 2005, Human molecular genetics.

[31]  R. DePinho,et al.  The LKB1 tumor suppressor negatively regulates mTOR signaling. , 2004, Cancer cell.

[32]  R. DePinho,et al.  Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. , 2004, Genes & development.

[33]  K. Inoki,et al.  TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival , 2003, Cell.

[34]  R. DePinho,et al.  LKB1 (XEEK1) regulates Wnt signalling in vertebrate development , 2003, Nature Cell Biology.

[35]  Hans Clevers,et al.  MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm , 2003 .

[36]  J. Howell,et al.  A Novel Hypoxia-inducible Factor-independent Hypoxic Response Regulating Mammalian Target of Rapamycin and Its Targets* , 2003, Journal of Biological Chemistry.

[37]  A. Ashworth,et al.  Regulation of the Wnt signalling component PAR1A by the Peutz–Jeghers syndrome kinase LKB1 , 2003, Oncogene.

[38]  H C Clevers,et al.  Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD , 2003, The EMBO journal.

[39]  D. Alessi,et al.  Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz‐Jeghers Syndrome patients , 2003, Human mutation.

[40]  N. Kimura,et al.  A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway , 2003, Genes to cells : devoted to molecular & cellular mechanisms.

[41]  David Sidransky,et al.  Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. , 2002, Cancer research.

[42]  A. Ashworth,et al.  LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. , 2001, Human molecular genetics.

[43]  S. Goodman,et al.  Very high risk of cancer in familial Peutz-Jeghers syndrome. , 2000, Gastroenterology.

[44]  R. Poulsom,et al.  In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours , 2000, The Journal of pathology.

[45]  M. Stratton,et al.  A serine/threonine kinase gene defective in Peutz–Jeghers syndrome , 1998, Nature.

[46]  V. McKusick,et al.  Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance. , 1949, The New England journal of medicine.

[47]  D. Hayes,et al.  The LKB 1 Tumor Suppressor as a Biomarker in Mouse and Human Tissues , 2013 .

[48]  Hans C Clevers,et al.  MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. , 2003, The EMBO journal.

[49]  J. Nezu,et al.  Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. , 1998, Nature genetics.