Unlocking the Mdm2-p53 loop: Ubiquitin is the key
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[1] R. Copeland,et al. Quantitative assays of Mdm2 ubiquitin ligase activity and other ubiquitin-utilizing enzymes for inhibitor discovery. , 2005, Methods in enzymology.
[2] Lawrence A. Donehower,et al. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53 , 1995, Nature.
[3] M. Jackson,et al. MdmX Protects p53 from Mdm2-Mediated Degradation , 2000, Molecular and Cellular Biology.
[4] Ken Chen,et al. The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53 , 1998, Cell.
[5] Jun Qin,et al. ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor , 2005, Cell.
[6] G. Wahl,et al. A New Twist in the Feedback Loop: Stress-Activated MDM2 Destabilization is Required for p53 Activation , 2005, Cell cycle.
[7] Yue Xiong,et al. ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways , 1998, Cell.
[8] G. Evan,et al. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. , 2007, Cancer cell.
[9] R. Honda,et al. Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase , 2000, Oncogene.
[10] A. Levine,et al. The MDM2 Oncoprotein Binds Specifically to RNA through its RING Finger Domain , 1996, Molecular medicine.
[11] S. Letteboer,et al. Hdmx Protein Stability Is Regulated by the Ubiquitin Ligase Activity of Mdm2* , 2003, Journal of Biological Chemistry.
[12] Bert Vogelstein,et al. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 , 1993, Nature.
[13] M. Kubbutat,et al. Regulation of HDM2 activity by the ribosomal protein L11. , 2003, Cancer cell.
[14] S. Francoz,et al. Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[15] C. Maki,et al. The MDM2 RING-finger domain is required to promote p53 nuclear export , 2000, Nature Cell Biology.
[16] C. Prives,et al. Unleashing the power of p53: lessons from mice and men. , 2006, Genes & development.
[17] R. Tjian,et al. Repression of p53-mediated transcription by MDM2: a dual mechanism. , 1997, Genes & development.
[18] O. Cuvier,et al. Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2 , 2007, Nature Cell Biology.
[19] A. Jochemsen,et al. Mdmx and Mdm2: Brothers in Arms? , 2004, Cell cycle.
[20] A. Ciechanover,et al. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53 , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[21] K. Shirouzu,et al. MDM2 interacts with MDMX through their RING finger domains , 1999, FEBS letters.
[22] G. Wahl,et al. Accelerated MDM2 auto‐degradation induced by DNA‐damage kinases is required for p53 activation , 2004, The EMBO journal.
[23] G. Peters,et al. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus , 2001, Nature Cell Biology.
[24] D. George,et al. Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein* , 1999, The Journal of Biological Chemistry.
[25] G. Wahl,et al. A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. , 2006, Cancer cell.
[26] M. Rolfe,et al. Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[27] M. Oren,et al. Mdm2 promotes the rapid degradation of p53 , 1997, Nature.
[28] Hirofumi Tanaka,et al. Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 , 1997, FEBS letters.
[29] N. Little,et al. Hdmx stabilizes Mdm2 and p53. , 2000, The Journal of biological chemistry.
[30] Mihee M. Kim,et al. RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity. , 2007, Cancer research.
[31] Stephen N. Jones,et al. Regulation of p53 stability by Mdm2 , 1997, Nature.
[32] L. Vassilev,et al. In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 , 2004, Science.
[33] G. Wahl,et al. Regulating the p53 pathway: in vitro hypotheses, in vivo veritas , 2006, Nature Reviews Cancer.
[34] A. Levine,et al. Regulation of Transcription Functions of the p53 Tumor Suppressor by the mdm-2 Oncogene , 1995, Molecular medicine.
[35] Yu Pan,et al. MDM2 Promotes Ubiquitination and Degradation of MDMX , 2003, Molecular and Cellular Biology.
[36] M. Oren,et al. The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. , 2004, Molecular cell.
[37] G. Evan,et al. Temporal dissection of p53 function in vitro and in vivo , 2005, Nature Genetics.
[38] Guillermina Lozano,et al. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53 , 1995, Nature.
[39] M. Kubbutat,et al. Identification of a cryptic nucleolar-localization signal in MDM2 , 2000, Nature Cell Biology.
[40] A. Levine,et al. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation , 1992, Cell.
[41] Charles J. Sherr,et al. Nucleolar Arf sequesters Mdm2 and activates p53 , 1999, Nature Cell Biology.
[42] Guillermina Lozano,et al. Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation , 2003, Cell.
[43] L. Vassilev,et al. MDM2 inhibitors for cancer therapy. , 2007, Trends in molecular medicine.
[44] T. Allio,et al. Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway , 2003, Molecular and Cellular Biology.
[45] Andrea Ciliberto,et al. Steady States and Oscillations in the p53/Mdm2 Network , 2005, Cell cycle.
[46] Jeremy R Stuart,et al. DNA Damage-induced MDMX Degradation Is Mediated by MDM2* , 2003, Journal of Biological Chemistry.
[47] Patrick Dowd,et al. The ubiquitin ligase COP1 is a critical negative regulator of p53 , 2004, Nature.
[48] Pankaj Oberoi,et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. , 2005, Cancer cell.
[49] Shengyun Fang,et al. Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53* , 2000, The Journal of Biological Chemistry.
[50] M. Chalfie,et al. Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. , 2003, Molecular cell.