Potential applications of polymers in the delivery of drugs to the central nervous system

[1]  V. Alakhov,et al.  Block copolymeric biotransport carriers as versatile vehicles for drug delivery. , 1998, Expert opinion on biological therapy.

[2]  W. Pardridge,et al.  Pharmacokinetics and blood-brain barrier transport of an anti-transferrin receptor monoclonal antibody (OX26) in rats after chronic treatment with the antibody. , 1998, Drug metabolism and disposition: the biological fate of chemicals.

[3]  R. Bergmann,et al.  Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells , 1998, Journal of neurochemistry.

[4]  M. Barrand,et al.  Multidrug Resistance‐Related Transport Proteins in Isolated Human Brain Microvessels and in Cells Cultured from These Isolates , 1998, Journal of neurochemistry.

[5]  D. Miller,et al.  Expression of multidrug resistance-associated protein (MRP) in brain microvessel endothelial cells. , 1998, Biochemical and biophysical research communications.

[6]  A. Kabanov,et al.  Interactions of pluronic block copolymers with brain microvessel endothelial cells: evidence of two potential pathways for drug absorption. , 1997, Bioconjugate chemistry.

[7]  V. Hruby,et al.  Peptide targeting and delivery across the blood-brain barrier utilizing synthetic triglyceride esters: design, synthesis, and bioactivity. , 1997, Bioconjugate chemistry.

[8]  R. Borchardt,et al.  How structural features influence the biomembrane permeability of peptides. , 1996, Journal of pharmaceutical sciences.

[9]  D. Miller,et al.  Use of rhodamine 123 to examine the functional activity of P-glycoprotein in primary cultured brain microvessel endothelial cell monolayers. , 1996, Life sciences.

[10]  V. Hruby,et al.  Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability. , 1996, The Journal of pharmacology and experimental therapeutics.

[11]  Kazunori Kataoka,et al.  Block copolymer micelles as long-circulating drug vehicles , 1995 .

[12]  N. Weiner,et al.  Formulation factors affecting release of drug from topical vehicles. II. Effect of solubility on in vitro delivery of a series of n-alkyl p-aminobenzoates. , 1995, Journal of pharmaceutical sciences.

[13]  H. Mitsuya,et al.  Lipophilic, acid-stable, adenosine deaminase-activated anti-HIV prodrugs for central nervous system delivery. 3. 6-Amino prodrugs of 2'-beta-fluoro-2',3'-dideoxyinosine. , 1995, Journal of medicinal chemistry.

[14]  Donald W. Miller,et al.  Identification and distribution of insulin receptors on cultured bovine brain microvessel endothelial cells: Possible function in insulin processing in the blood–brain barrier , 1994, Journal of cellular physiology.

[15]  J. H. Beijnen,et al.  Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs , 1994, Cell.

[16]  N. Bodor,et al.  Enhanced delivery of ganciclovir to the brain through the use of redox targeting , 1994, Antimicrobial Agents and Chemotherapy.

[17]  M. Nakakura,et al.  Blood clearance and tissue distribution of various formulations of alpha-tocopherol injection after intravenous administration. , 1993, Chemical & pharmaceutical bulletin.

[18]  Alexander V. Kabanov,et al.  A new class of drug carriers: micelles of poly(oxyethylene)-poly(oxypropylene) block copolymers as microcontainers for drug targeting from blood in brain☆ , 1992 .

[19]  N. Bodor,et al.  A strategy for delivering peptides into the central nervous system by sequential metabolism. , 1992, Science.

[20]  T. Kararli,et al.  Solubilization and dissolution properties of a leukotriene-D4 antagonist in micellar solutions. , 1992, Journal of pharmaceutical sciences.

[21]  D. Lasič Mixed micelles in drug delivery , 1992, Nature.

[22]  Ito Seiji,et al.  Methyl ester of prostaglandin D2 as a delivery system of prostaglandin D2 into brain. , 1987 .

[23]  H. Ringsdorf,et al.  Micelle-forming block copolymers: Pinocytosis by macrophages and interaction with model membranes , 1985 .

[24]  W. Pardridge,et al.  Pharmacokinetics and blood-brain barrier transport of [3H]-biotinylated phosphorothioate oligodeoxynucleotide conjugated to a vector-mediated drug delivery system. , 1996, The Journal of pharmacology and experimental therapeutics.

[25]  G. Amidon,et al.  Peptide-based Drug Design, Controlling Transport and Metabolism , 1995 .

[26]  I. Toth A novel chemical approach to drug delivery: lipidic amino acid conjugates. , 1994, Journal of drug targeting.

[27]  M. Hashida,et al.  Controlled biodistribution of highly lipophilic drugs with various parenteral formulations. , 1993, Journal of drug targeting.

[28]  M. Yokoyama Block copolymers as drug carriers. , 1992, Critical reviews in therapeutic drug carrier systems.

[29]  E. Neuwelt,et al.  Implications of the Blood-Brain Barrier and Its Manipulation , 1989, Springer US.