Dual-Stimuli Responsive Bismuth Nanoraspberries for Multimodal Imaging and Combined Cancer Therapy.

Development of stimuli-responsive theranostics is of great importance for precise cancer diagnosis and treatment. Herein, bovine serum albumin (BSA) modified bismuth nanoraspberries (Bi-BSA NRs) are developed as cancer theranostic agents for multimodal imaging and chemo-photothermal combination therapy. The Bi-BSA NRs are synthesized in aqueous phase via a facile reduction method using Bi2O3 nanospheres as the sacrificial template. The morphology, biocompatibility, photothermal effect, drug loading/releasing abilities, chemotherapy effect, synergistic chemo-photothermal therapy efficacy, and multimodal imaging capacities of Bi-BSA NRs have been investigated. The results show that the NRs possess multiple unique features including (i) raspberry-like morphology with high specific surface area (∼52.24 m2·g-1) and large cavity (total pore volume ∼0.30 cm3·g-1), promising high drug loading capacity (∼69 wt %); (ii) dual-stimuli responsive drug release, triggered by acidic pH and NIR laser irradiation; (iii) infrared thermal (IRT), photoacoustic (PA) and X-ray computed tomography (CT) trimodality imaging with the CT contrast enhanced efficiency as high as ∼66.7 HU·mL·mg-1; (iv) 100% tumor elimination through the combination chemo-photothermal therapy. Our work highlights the great potentials of Bi-BSA NRs as a versatile theranostics for multimodal imaging and combination therapy.

[1]  Dengfeng Yu,et al.  Core–Shell Bi2Se3@mSiO2‐PEG as a Multifunctional Drug‐Delivery Nanoplatform for Synergistic Thermo‐Chemotherapy with Infrared Thermal Imaging of Cancer Cells , 2018 .

[2]  Xiaodong Chen,et al.  Synergistic Lysosomal Activatable Polymeric Nanoprobe Encapsulating pH Sensitive Imidazole Derivative for Tumor Diagnosis. , 2018, Small.

[3]  Xiaodong Chen,et al.  Nanomechanical Force Mapping of Restricted Cell-To-Cell Collisions Oscillating between Contraction and Relaxation. , 2017, ACS nano.

[4]  Yuliang Zhao,et al.  Synthesis of BSA‐Coated BiOI@Bi2S3 Semiconductor Heterojunction Nanoparticles and Their Applications for Radio/Photodynamic/Photothermal Synergistic Therapy of Tumor , 2017, Advanced materials.

[5]  Younan Xia,et al.  A Eutectic Mixture of Natural Fatty Acids Can Serve as the Gating Material for Near‐Infrared‐Triggered Drug Release , 2017, Advanced materials.

[6]  F. Besenbacher,et al.  Biocompatible PEGylated bismuth nanocrystals: "All-in-one" theranostic agent with triple-modal imaging and efficient in vivo photothermal ablation of tumors. , 2017, Biomaterials.

[7]  Shuyan Song,et al.  Ultrafast Synthesis of Ultrasmall Poly(Vinylpyrrolidone)‐Protected Bismuth Nanodots as a Multifunctional Theranostic Agent for In Vivo Dual‐Modal CT/Photothermal‐Imaging‐Guided Photothermal Therapy , 2017 .

[8]  Xiaodong Chen,et al.  Orientational Coupling Locally Orchestrates a Cell Migration Pattern for Re‐Epithelialization , 2017, Advanced materials.

[9]  K. Zhong,et al.  A pH-Responsive Yolk-Like Nanoplatform for Tumor Targeted Dual-Mode Magnetic Resonance Imaging and Chemotherapy. , 2017, ACS nano.

[10]  Xiaoyuan Wang,et al.  Programmable Nano–Bio Interfaces for Functional Biointegrated Devices , 2017, Advanced materials.

[11]  Xiaoyuan Chen,et al.  Tumor Microenvironment‐Triggered Supramolecular System as an In Situ Nanotheranostic Generator for Cancer Phototherapy , 2017, Advanced materials.

[12]  Xiaodong Chen,et al.  Nanomechanically Visualizing Drug-Cell Interaction at the Early Stage of Chemotherapy. , 2017, ACS nano.

[13]  Kai Yang,et al.  Ultrasmall Semimetal Nanoparticles of Bismuth for Dual-Modal Computed Tomography/Photoacoustic Imaging and Synergistic Thermoradiotherapy. , 2017, ACS nano.

[14]  Mingyuan Gao,et al.  Ultrasmall Biocompatible Bi2Se3 Nanodots for Multimodal Imaging-Guided Synergistic Radiophotothermal Therapy against Cancer. , 2016, ACS nano.

[15]  Jarno Salonen,et al.  Gold Nanorods, DNA Origami, and Porous Silicon Nanoparticle‐functionalized Biocompatible Double Emulsion for Versatile Targeted Therapeutics and Antibody Combination Therapy , 2016, Advanced materials.

[16]  Miao Yu,et al.  Multimodal Imaging-Guided Antitumor Photothermal Therapy and Drug Delivery Using Bismuth Selenide Spherical Sponge. , 2016, ACS nano.

[17]  F. Besenbacher,et al.  Highly porous PEGylated Bi2S3 nano-urchins as a versatile platform for in vivo triple-modal imaging, photothermal therapy and drug delivery. , 2016, Nanoscale.

[18]  Mingyuan Gao,et al.  BSA‐Mediated Synthesis of Bismuth Sulfide Nanotheranostic Agents for Tumor Multimodal Imaging and Thermoradiotherapy , 2016 .

[19]  Nan Lu,et al.  A Multifunctional PB@mSiO2-PEG/DOX Nanoplatform for Combined Photothermal-Chemotherapy of Tumor. , 2016, ACS applied materials & interfaces.

[20]  Zhen Gu,et al.  Light‐Activated Hypoxia‐Responsive Nanocarriers for Enhanced Anticancer Therapy , 2016, Advanced materials.

[21]  Yuliang Zhao,et al.  Gadolinium polytungstate nanoclusters: a new theranostic with ultrasmall size and versatile properties for dual-modal MR/CT imaging and photothermal therapy/radiotherapy of cancer , 2016 .

[22]  Xiaodong Chen,et al.  Bio‐Inspired Mechanotactic Hybrids for Orchestrating Traction‐Mediated Epithelial Migration , 2016, Advanced materials.

[23]  F. Besenbacher,et al.  Multifunctional Bismuth Selenide Nanocomposites for Antitumor Thermo-Chemotherapy and Imaging. , 2016, ACS Nano.

[24]  Tingting Jiang,et al.  Human‐Serum‐Albumin‐Coated Prussian Blue Nanoparticles as pH‐/Thermotriggered Drug‐Delivery Vehicles for Cancer Thermochemotherapy , 2016 .

[25]  Yuliang Zhao,et al.  One-pot synthesis of PEGylated plasmonic MoO(3-x) hollow nanospheres for photoacoustic imaging guided chemo-photothermal combinational therapy of cancer. , 2016, Biomaterials.

[26]  Kai Yang,et al.  Bottom-Up Synthesis of Metal-Ion-Doped WS₂ Nanoflakes for Cancer Theranostics. , 2015, ACS nano.

[27]  Yuliang Zhao,et al.  Smart Albumin‐Biomineralized Nanocomposites for Multimodal Imaging and Photothermal Tumor Ablation , 2015, Advanced materials.

[28]  Kai Yang,et al.  Semimetal nanomaterials of antimony as highly efficient agent for photoacoustic imaging and photothermal therapy. , 2015, Biomaterials.

[29]  Y. Liu,et al.  Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor. , 2015, ACS nano.

[30]  Y. Huang,et al.  Bi2S3-embedded mesoporous silica nanoparticles for efficient drug delivery and interstitial radiotherapy sensitization. , 2015, Biomaterials.

[31]  Xiaoyuan Chen,et al.  In vivo albumin labeling and lymphatic imaging , 2014, Proceedings of the National Academy of Sciences.

[32]  Yan Hu,et al.  Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity. , 2014, Biomaterials.

[33]  Xibo Ma,et al.  Encapsulating tantalum oxide into polypyrrole nanoparticles for X-ray CT/photoacoustic bimodal imaging-guided photothermal ablation of cancer. , 2014, Biomaterials.

[34]  Jie Yu,et al.  High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy. , 2014, ACS nano.

[35]  Xiaolong Liu,et al.  Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma. , 2014, Journal of materials chemistry. B.

[36]  Gang Liu,et al.  PEGylated WS2 Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy , 2014, Advanced materials.

[37]  Q. Zhang,et al.  Gold nanoshelled liquid perfluorocarbon nanocapsules for combined dual modal ultrasound/CT imaging and photothermal therapy of cancer. , 2014, Small.

[38]  Wei Long,et al.  Metabolizable Bi2Se3 Nanoplates: Biodistribution, Toxicity, and Uses for Cancer Radiation Therapy and Imaging , 2013, 1312.1773.

[39]  Z. Dai,et al.  Covalent attachment of Mn-porphyrin onto doxorubicin-loaded poly(lactic acid) nanoparticles for potential magnetic resonance imaging and pH-sensitive drug delivery. , 2013, Acta biomaterialia.

[40]  Guonan Chen,et al.  Topological insulator bismuth selenide as a theranostic platform for simultaneous cancer imaging and therapy , 2013, Scientific Reports.

[41]  T. Bein,et al.  Targeted drug delivery in cancer cells with red-light photoactivated mesoporous silica nanoparticles. , 2013, Nano letters.

[42]  Jianan Liu,et al.  NIR-triggered anticancer drug delivery by upconverting nanoparticles with integrated azobenzene-modified mesoporous silica. , 2013, Angewandte Chemie.

[43]  Qiushi Ren,et al.  Uniform Polypyrrole Nanoparticles with High Photothermal Conversion Efficiency for Photothermal Ablation of Cancer Cells , 2013, Advanced materials.

[44]  Gert Storm,et al.  Gold nanoparticles in theranostic oncology: current state-of-the-art , 2012, Expert opinion on drug delivery.

[45]  Qian Huang,et al.  Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm. , 2012, ACS nano.

[46]  Jun Lin,et al.  Functionalized mesoporous silica materials for controlled drug delivery. , 2012, Chemical Society reviews.

[47]  Jing Wang,et al.  Mesoporous Silica‐Coated Gold Nanorods as a Light‐Mediated Multifunctional Theranostic Platform for Cancer Treatment , 2012, Advanced materials.

[48]  Gang Liu,et al.  Hollow iron oxide nanoparticles as multidrug resistant drug delivery and imaging vehicles , 2012, Nano Research.

[49]  Matthew G. Panthani,et al.  Copper selenide nanocrystals for photothermal therapy. , 2011, Nano letters.

[50]  Samuel Woojoo Jun,et al.  Large-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping. , 2011, Journal of the American Chemical Society.

[51]  Dong Chen,et al.  Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity. , 2011, Angewandte Chemie.

[52]  Yu Chen,et al.  Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery. , 2010, ACS nano.

[53]  Jianping Xie,et al.  Protein-directed synthesis of highly fluorescent gold nanoclusters. , 2009, Journal of the American Chemical Society.

[54]  S. Emelianov,et al.  Photoacoustic imaging and temperature measurement for photothermal cancer therapy. , 2008, Journal of biomedical optics.

[55]  Sangjin Park,et al.  Antibiofouling polymer-coated gold nanoparticles as a contrast agent for in vivo X-ray computed tomography imaging. , 2007, Journal of the American Chemical Society.

[56]  M. Hoepfner,et al.  Microscale Heat Transfer Transduced by Surface Plasmon Resonant Gold Nanoparticles. , 2007, The journal of physical chemistry. C, Nanomaterials and interfaces.

[57]  M. Gottesman,et al.  Targeting multidrug resistance in cancer , 2006, Nature Reviews Drug Discovery.

[58]  V. Torchilin.  Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[59]  R. Price,et al.  Thermal therapy of canine cerebral tumors using a 980 nm diode laser with MR temperature‐sensitive imaging feedback , 2004, Lasers in surgery and medicine.

[60]  R. Weissleder.  A clearer vision for in vivo imaging , 2001, Nature Biotechnology.