A modeling framework for evaluation and comparison of trigger strategies for switching from minipool to individual‐donation testing for West Nile virus

BACKGROUND: To decrease the likelihood of transmission from donations containing West Nile virus (WNV) levels below minipool nucleic acid test (MP‐NAT) detection limits, blood centers switch from MP‐NAT to individual‐donation testing (ID‐NAT) after detection of MP‐NAT–positive donations. The effectiveness of strategies to trigger or discontinue ID‐NAT screening is largely unknown.