A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women.

Adherence to a Mediterranean-style diet is associated with a lower risk for mortality, cognitive decline, and dementia. Whether adherence to a Mediterranean-style diet protects against age-related frailty is unclear. Therefore, our objective was to examine the association between a Mediterranean-style diet with the risk of frailty in community-dwelling older persons. We conducted longitudinal analyses using data from 690 community-living persons (≥65 y) who were randomly selected from a population registry in Tuscany, Italy. Participants of the Invecchiare in Chianti study of aging completed the baseline examination in 1998-2000 and were re-examined at least once over 6 y. Adherence to a Mediterranean-style diet (scored 0-9, modeled categorically as ≤3, 4-5, and ≥6) was computed from the European Prospective Investigation into Cancer and nutrition FFQ previously validated in this cohort. Frailty was defined as having at least 2 of the following criteria: poor muscle strength, feeling of exhaustion, low walking speed, and low physical activity. After a 6-y follow-up, higher adherence (score ≥6) to a Mediterranean-style diet was associated with lower odds of developing frailty [OR = 0.30 (95% CI: 0.14, 0.66)] compared with those with lower adherence (score ≤3). A higher adherence to a Mediterranean-style diet at baseline was also associated with a lower risk of low physical activity (OR = 0.62; 95% CI: 0.40, 0.96) and low walking speed [OR = 0.48 (95% CI: 0.27, 0.86)] but not with feelings of exhaustion and poor muscle strength. In community-dwelling older adults, higher adherence to a Mediterranean-style diet was inversely associated with the development of frailty.

[1]  C. Cooper,et al.  Nutrition and Sarcopenia: A Review of the Evidence and Implications for Preventive Strategies , 2012, Journal of aging research.

[2]  S. Bandinelli,et al.  Serum 25‐Hydroxyvitamin D, Transitions Between Frailty States, and Mortality in Older Adults: The Invecchiare in Chianti Study , 2012, Journal of the American Geriatrics Society.

[3]  Luigi Ferrucci,et al.  Mediterranean diet and mobility decline in older persons , 2011, Experimental Gerontology.

[4]  Q. Xue.  The frailty syndrome: definition and natural history. , 2011, Clinics in geriatric medicine.

[5]  Rosanna Abbate,et al.  Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. , 2010, The American journal of clinical nutrition.

[6]  G. Chertow,et al.  Vitamin D deficiency and frailty in older Americans , 2010, Journal of internal medicine.

[7]  R. Hubbard,et al.  Frailty, inflammation and the elderly , 2010, Biogerontology.

[8]  K. Tucker.  Dietary patterns, approaches, and multicultural perspective. , 2010, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

[9]  A. LaCroix,et al.  Protein Intake and Incident Frailty in the Women's Health Initiative Observational Study , 2010, Journal of the American Geriatrics Society.

[10]  K. Markides,et al.  Frailty and 10-Year Mortality in Community-Living Mexican American Older Adults , 2009, Gerontology.

[11]  Virginie Rondeau,et al.  Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. , 2009, JAMA.

[12]  D A Bennett,et al.  Change in Frailty and Risk of Death in Older Persons , 2009, Experimental aging research.

[13]  J. Blass.  Mediterranean Diet and Mild Cognitive Impairment , 2009 .

[14]  C. Cooper,et al.  The developmental origins of sarcopenia , 2008, The journal of nutrition, health & aging.

[15]  Rosanna Abbate,et al.  Adherence to Mediterranean diet and health status: meta-analysis , 2008, BMJ : British Medical Journal.

[16]  J. Purser,et al.  Frailty Predicts Some but Not All Adverse Outcomes in Older Adults Discharged from the Emergency Department , 2008, Journal of the American Geriatrics Society.

[17]  C. Jankowski.  Oxidative protein damage is associated with poor grip strength among older women living in the community , 2008 .

[18]  K. Tucker,et al.  Dietary patterns: challenges and opportunities in dietary patterns research an Experimental Biology workshop, April 1, 2006. , 2007, Journal of the American Dietetic Association.

[19]  H. Cohen,et al.  Frailty thy name is ... Phrailty? , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[20]  W. Ershler.  A gripping reality: oxidative stress, inflammation, and the pathway to frailty. , 2007, Journal of applied physiology.

[21]  Hannah J. Zhang,et al.  An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

[22]  L. Fried,et al.  Low serum micronutrient concentrations predict frailty among older women living in the community. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[23]  S. Bandinelli,et al.  Low nutrient intake is an essential component of frailty in older persons. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[24]  L. Fried,et al.  Vitamin and carotenoid status in older women: associations with the frailty syndrome. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[25]  L. Ferrucci,et al.  Phenotype of frailty: characterization in the women's health and aging studies. , 2006, The journals of gerontology. Series A, Biological sciences and medical sciences.

[26]  Thomas M Gill,et al.  Transitions between frailty states among community-living older persons. , 2006, Archives of internal medicine.

[27]  L. Fried,et al.  Frailty, hospitalization, and progression of disability in a cohort of disabled older women. , 2005, The American journal of medicine.

[28]  Katherine L Tucker,et al.  Empirically derived eating patterns using factor or cluster analysis: a review. , 2004, Nutrition reviews.

[29]  S. Bandinelli,et al.  Dietary intake estimated using different methods in two Italian older populations. , 2004, Archives of gerontology and geriatrics.

[30]  Raymond J Carroll,et al.  Structure of dietary measurement error: results of the OPEN biomarker study. , 2003, American journal of epidemiology.

[31]  Tina Costacou,et al.  Adherence to a Mediterranean diet and survival in a Greek population. , 2003, The New England journal of medicine.

[32]  L. Fried,et al.  Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. , 2002, Archives of internal medicine.

[33]  L. Fried,et al.  Frailty in older adults: evidence for a phenotype. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[34]  L. Fried,et al.  Associations of subclinical cardiovascular disease with frailty. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[35]  Luigi Ferrucci,et al.  Subsystems Contributing to the Decline in Ability to Walk: Bridging the Gap Between Epidemiology and Geriatric Practice in the InCHIANTI Study , 2000, Journal of the American Geriatrics Society.

[36]  C. Y. Wang,et al.  NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. , 2000, Science.

[37]  Linda P. Fried,et al.  The Women's Health and Aging Study: Health and Social Characteristics of Older Women with Disability , 1995 .

[38]  J F Sallis,et al.  Compendium of physical activities: classification of energy costs of human physical activities. , 1993, Medicine and science in sports and exercise.

[39]  L. Radloff.  The CES-D Scale , 1977 .

[40]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.