Polycyclic aromatic hydrocarbon oxidation during prostaglandin biosynthesis.

[1]  L. Marnett,et al.  Hydroperoxide-dependent oxygenation of trans-7,8-dihydroxy-7,8-dihydro benzo[a]pyrene by ram seminal vesicle microsomes. Source of the oxygen. , 1980, Biochemical and biophysical research communications.

[2]  T. Zenser,et al.  Co-oxidative metabolism of 2-amino-4-(5-nitro-2-furyl)-thiazole by prostaglandin hydroperoxidase. , 1980, The Journal of laboratory and clinical medicine.

[3]  T. Zenser,et al.  Mechanism of FANFT cooxidation by prostaglandin endoperoxide synthetase. , 1980, The Journal of pharmacology and experimental therapeutics.

[4]  H. Armbrecht,et al.  Benzidine binding to nucleic acids mediated by the peroxidative activity of prostaglandin endoperoxide synthetase. , 1980, Cancer research.

[5]  F. DeRubertis,et al.  Fatty acid induced drug and carcinogen metabolism in rat and human colonic mucosa: a possible link to the association of high dietary fat intake and colonic carcinogenesis. , 1980, Biochemical and biophysical research communications.

[6]  W. Smith,et al.  Subcellular localization of prostaglandin-forming cyclooxygenase in Swiss mouse 3T3 fibroblasts by electron microscopic immunocytochemistry. , 1980, The Journal of biological chemistry.

[7]  R. Egan,et al.  Mechanism of oxygen transfer by prostaglandin hydroperoxidase. , 1980, The Journal of biological chemistry.

[8]  T. Zenser,et al.  Cooxygenation by prostaglandin cyclooxygenase from rabbit inner medulla. , 1979, Kidney international.

[9]  T. Zenser,et al.  Cooxidation of benzidine by renal medullary prostaglandin cyclooxygenase. , 1979, The Journal of pharmacology and experimental therapeutics.

[10]  M. J. Coon,et al.  Catalytic activity and stereoselectivity of purified forms of rabbit liver microsomal cytochrome P-450 in the oxygenation of the (-) and (+) enantiomers of trans-7,8-dihydroxy-7,8-dihydrobenzo[alpha]pyrene. , 1979, Molecular pharmacology.

[11]  H. Mukhtar,et al.  Arachidonic acid‐dependent metabolism of (±) trans‐7,8‐dihydroxy‐7,8‐ dihydro‐benzo[a]pyrene (BP‐7,8 diol) to 7,10/8,9 tetrols , 1979, FEBS letters.

[12]  L. Marnett,et al.  Arachidonic acid‐dependent metabolism of 7,8‐dihydroxy‐7,8‐dihydrobenzo[a]pyrene by ram seminal vesicles , 1979, FEBS letters.

[13]  J. Dumont,et al.  Prostaglandin formation in bacteria. , 1979, Prostaglandins.

[14]  C. Van Dyke,et al.  A new screening system for nonsteroidal anti-inflammatory drugs based upon inhibition of chemiluminescence produced from human cells (granulocytes). , 1979, Clinical chemistry.

[15]  L. Marnett,et al.  Peroxidatic oxidation of benzo[a]pyrene and prostaglandin biosynthesis. , 1979, Biochemistry.

[16]  L. Marnett,et al.  Oxygen 18 investigation of the prostaglandin synthetase-dependent co-oxidation of diphenylisobenzofuran. , 1979, The Journal of biological chemistry.

[17]  J. Vane,et al.  A new approach to anti-inflammatory drugs. , 1979, Biochemical pharmacology.

[18]  R. Egan,et al.  Reduction of hydroperoxides in the prostaglandin biosynthetic pathway by a microsomal peroxidase. , 1979, The Journal of biological chemistry.

[19]  S. Yamamoto,et al.  Isolation of an activator for prostaglandin hydroperoxidase from bovine vesicular gland cytosol and its identification as uric acid. , 1979, Biochemical and biophysical research communications.

[20]  T. Zenser,et al.  Demonstration of separate pathways for the metabolism of organic compounds in rabbit kidney. , 1979, The Journal of pharmacology and experimental therapeutics.

[21]  M. Buytenhek,et al.  On the haemoprotein character of prostaglandin endoperoxide synthetase. , 1979, Biochimica et biophysica acta.

[22]  T. Eling,et al.  Metabolism of benzo(a)pyrene to reactive intermediate(s) via prostaglandin biosynthesis. , 1978, Life sciences.

[23]  R. Egan,et al.  Radical scavenging as the mechanism for stimulation of prostaglandin cyclooxygenase and depression of inflammation by lipoic acid and sodium iodide. , 1978, Prostaglandins.

[24]  A. Marcus.  The role of lipids in platelet function: with particular reference to the arachidonic acid pathway. , 1978, Journal of lipid research.

[25]  D. Jerina,et al.  Stereoelectronic factors in the solvolysis of bay region diol epoxides of polycyclic aromatic hydrocarbons , 1978 .

[26]  S. Yamamoto,et al.  Prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. Inactivation and activation by heme and other metalloporphyrins. , 1978, The Journal of biological chemistry.

[27]  L. Marnett,et al.  Prostaglandin synthetase dependent activation of 7,8-dihydro-7,8-dihydroxy-geno (a) pyrene to mutagenic derivativies. , 1978, Biochemical and biophysical research communications.

[28]  J. Salmon,et al.  Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes. , 1978, Biochimica et biophysica acta.

[29]  D. Jerina,et al.  Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (+/-)-trans-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice. , 1978, Cancer research.

[30]  S. Bhat,et al.  Biosynthesis of a prostaglandin by a plant enzyme. , 1978, The Journal of biological chemistry.

[31]  L. Marnett,et al.  Prostaglandin synthetase dependent benzo(a)pyrene oxidation: products of the oxication and inhibition of their formation by antioxidants. , 1977, Biochemical and biophysical research communications.

[32]  A. Y. Lu,et al.  Structural requirements for the metabolic activation of benzo[a]pyrene to mutagenic products: effects of modifications in the 4,5-, 7,8-, and 9,10-positions. , 1977, Molecular pharmacology.

[33]  M. Calvin,et al.  Benzo[a]pyrene diol epoxide covalently binds to deoxyguanosine and deoxyadenosine in DNA , 1977, Nature.

[34]  C. Harris,et al.  Structures of benzo(a)pyrene–nucleic acid adducts formed in human and bovine bronchial explants , 1977, Nature.

[35]  T. Slaga,et al.  The effects of benzoflavones on polycyclic hydrocarbon metabolism and skin tumor initiation. , 1977, Chemico-biological interactions.

[36]  M. Buytenhek,et al.  Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands. , 1977, Biochimica et biophysica acta.

[37]  D. Jerina,et al.  Metabolism of benzo[a]pyrene. VI. Stereoselective metabolism of benzo[a]pyrene and benzo[a]pyrene 7,8-dihydrodiol to diol epoxides. , 1977, Chemico-biological interactions.

[38]  S. Yamamoto,et al.  Prostaglandin endoperoxide E isomerase from bovine vesicular gland microsomes, a glutathione-requiring enzyme. , 1977, The Journal of biological chemistry.

[39]  R. Egan,et al.  Mechanism for irreversible self-deactivation of prostaglandin synthetase. , 1976, The Journal of biological chemistry.

[40]  R. A. Johnson,et al.  The chemical structure of prostaglandin X (prostacyclin). , 1976, Prostaglandins.

[41]  C. Heidelberger,et al.  Hydrolysis of syn- and anti-benzo[a]pyrene diol epoxides: stereochemistry, kinetics, and the effect of an intramolecular hydrogen bond on the rate of syn-diol epoxide solvolysis , 1976 .

[42]  W. Lands,et al.  Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme. , 1976, The Journal of biological chemistry.

[43]  D. Jerina,et al.  Mutagenicity and cytotoxicity of benzo(a)pyrene arene oxides, phenols, quinones, and dihydrodiols in bacterial and mammalian cells. , 1976, Cancer research.

[44]  P. D. Sullivan,et al.  Free radicals derived from benzo[a]pyrene. , 1976, Biochemical and biophysical research communications.

[45]  S. Yamamoto,et al.  Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. , 1976, The Journal of biological chemistry.

[46]  Nomura Tadasi,et al.  Distribution of prostaglandins in the animal kingdom. , 1976 .

[47]  C. Pace-Asciak.  Letter: Isolation, structure, and biosynthesis of 6-ketoprostaglandin F1 alpha in the rat stomach. , 1976, Journal of the American Chemical Society.

[48]  L. Marnett,et al.  Co-oxygenation of organic substrates by the prostaglandin synthetase of sheep vesicular gland. , 1975, The Journal of biological chemistry.

[49]  W. Caspary,et al.  Autoxidation of 6-hydroxybenzo(a)pyrene and 6-oxobenzo(a)pyrene radical, reactive metabolites of benzo(a)pyrene , 1975 .

[50]  W. Caspary,et al.  Enzymic formation of 6-oxobenzo[a]pyrene radical in rat liver homogenates from carcinogenic benzo[a]pyrene , 1975 .

[51]  F. Vane,et al.  The biosynthesis of 1a, 1b-dihomo-PGF2 and 1a,1b-dihomo-PGF2 alpha from 7, 10, 13, 16-docosatetraenoic acid by an acetone-pentane powder of sheep vesicular gland microsomes. , 1975, Prostaglandins.

[52]  J. Howard,et al.  Autoxidation and Photooxidation of 1,3-Diphenylisobenzofuran: A Kinetic and Product Study , 1975 .

[53]  P. Portoghese,et al.  Oxidation of oxyphenbutazone by sheep vesicular gland microsomes and lipoxygenase. , 1975, Biochemical and biophysical research communications.

[54]  P. O'Brien,et al.  Hydroperoxide dependent O-dealkylation reactions catalyzed by liver microsomal cytochrome P450. , 1975, Biochemical and biophysical research communications.

[55]  A. Hewer,et al.  Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide , 1974, Nature.

[56]  L. Marnett,et al.  Light emission during the action of prostaglandin synthetase. , 1974, Biochemical and Biophysical Research Communications - BBRC.

[57]  D. Nugteren,et al.  Isolation and properties of intermediates in prostaglandin biosynthesis. , 1973, Biochimica et biophysica acta.

[58]  W. Caspary,et al.  Electron paramagnetic resonance study of iodine-induced radicals of benzo( ) pyrene and other polycyclic hydrocarbons. , 1973, Biochemistry.

[59]  J. Mcgiff,et al.  Dependency of Renal Blood Flow on Prostaglandin Synthesis in the Dog , 1973, Circulation research.

[60]  A. Borgen,et al.  Metabolic conversion of benzo(a)pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid. , 1973, Journal of medicinal chemistry.

[61]  D. V. van Dorp,et al.  Comparative aspects of prostaglandin biosynthesis in animal tissues. , 1972, Biochimica et biophysica acta.

[62]  P. Sims,et al.  Epoxy derivatives of aromatic polycyclic hydrocarbons. The preparation and metabolism of epoxides related to benzo(a)pyrene and to 7,8- and 9,10-dihydrobenzo(a)pyrene. , 1972, The Biochemical journal.

[63]  C. Sih,et al.  Mechanism of prostaglandin biosynthesis. I. Characterization and assay of bovine prostaglandin synthetase. , 1971, Biochemistry.

[64]  R. Adams,et al.  Electrochemical oxidation pathways of benzo [a] pyrene. , 1970, Journal of the American Chemical Society.

[65]  J A Miller,et al.  Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture. , 1970, Cancer research.

[66]  M. Hamberg.  Biosynthesis of prostaglandins in the renal medulla of rabbit , 1969, FEBS letters.

[67]  D. V. van Dorp,et al.  The action of prostaglandin synthetase on 2-arachidonyl-lecithin. , 1968, Biochimica et biophysica acta.

[68]  B. Samuelsson,et al.  Phospholipid precursors of prostaglandins. , 1968, Biochimica et biophysica acta.

[69]  M. Hamberg,et al.  Oxygenation of unsaturated fatty acids by the vesicular gland of sheep. , 1967, The Journal of biological chemistry.

[70]  J. Morris,et al.  The production of carcinoma of the urinary bladder in rats by feeding N-[3-(5-nitro-2-furyl)-2-thiazolyl]formamide. , 1967, Cancer research.

[71]  H. Vonkeman.  [The biosynthesis of prostaglandins]. , 1964, Chemisch weekblad.

[72]  B. Samuelsson,et al.  THE ENZYMATIC FORMATION OF PROSTAGLANDIN E2 FROM ARACHIDONIC ACID PROSTAGLANDINS AND RELATED FACTORS 32. , 1964, Biochimica et biophysica acta.

[73]  C. Heidelberger,et al.  The distribution of radioactivity in mice following administration of 3,4-benzpyrene-5-C14 and 1,2,5,6-dibenzanthracene-9,10-C14. , 1951, Cancer research.

[74]  E. Miller.  Studies on the formation of protein-bound derivatives of 3,4-benzpyrene in the epidermal fraction of mouse skin. , 1951, Cancer research.

[75]  P. Shubik,et al.  Survey of Compounds Which Have Been Tested for Carcinogenic Activity , 1941 .

[76]  T. Zenser,et al.  Renal metabolism of drugs and xenobiotics. , 1981, Nephron.

[77]  T. Zenser,et al.  Metabolism of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide by prostaglandin endoperoxide synthetase. , 1980, Cancer research.

[78]  T. Shen.  Prostaglandin Synthetase Inhibitors I , 1977 .

[79]  B. Samuelsson,et al.  Advances in prostaglandin and thromboxane research , 1976 .

[80]  T. Haley.  Benzidine revisited: a review of the literature and problems associated with the use of benzidine and its congeners. , 1975, Clinical toxicology.

[81]  P. Grover,et al.  Epoxides in polycyclic aromatic hydrocarbon metabolism and carcinogenesis. , 1974, Advances in cancer research.

[82]  R. Boutwell,et al.  The function and mechanism of promoters of carcinogenesis. , 1974, CRC critical reviews in toxicology.