Polymer bound EDC (P-EDC): A convenient reagent for formation of an amide bond

Abstract A facile preparation of polymer bound 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (P-EDC) from commercially available starting materials is described. The P-EDC was found to be a convenient and general reagent for coupling of a variety of amines with diverse carboxylic acids.