Firmly anchored photosensitizer Chlorin e6 to layered double hydroxide nanoflakes for highly efficient photodynamic therapy in vivo.

In using nanomaterials for advanced photodynamic therapy, it is important to improve surface modification to increase stability, minimize non-specific loss of drugs in blood circulation, enhance the photostability of photosensitizers, and achieve highly efficient intracellular uptake. In this report, we for the first time covalently conjugate photosensitizer Chlorin e6 (Ce6) to polyethylene glycol modified layered double hydroxides and produce hybrid nanoflakes. These nanoflakes display many superior characteristics and lead to excellent in vivo photodynamic therapeutic efficiency and safety profiles.

[1]  G. Ma,et al.  Multitriggered Tumor-Responsive Drug Delivery Vehicles Based on Protein and Polypeptide Coassembly for Enhanced Photodynamic Tumor Ablation. , 2016, Small.

[2]  Chengbo Liu,et al.  Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer. , 2016, Biomaterials.

[3]  Pengfei Wang,et al.  Gold nanorod@silica-carbon dots as multifunctional phototheranostics for fluorescence and photoacoustic imaging-guided synergistic photodynamic/photothermal therapy. , 2016, Nanoscale.

[4]  Xin Du,et al.  Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery. , 2016, Biomaterials.

[5]  Ning Zhang,et al.  An Injectable Self‐Assembling Collagen–Gold Hybrid Hydrogel for Combinatorial Antitumor Photothermal/Photodynamic Therapy , 2016, Advanced materials.

[6]  Qiao Jiang,et al.  A Photosensitizer-Loaded DNA Origami Nanosystem for Photodynamic Therapy. , 2016, ACS nano.

[7]  W. Gu,et al.  Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay Nanoparticles. , 2016, Small.

[8]  H. Möhwald,et al.  Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy. , 2016, Angewandte Chemie.

[9]  Z. Xu,et al.  Crosslinking to enhance colloidal stability and redispersity of layered double hydroxide nanoparticles. , 2015, Journal of colloid and interface science.

[10]  Xin Du,et al.  Cancer-Cell-Specific Nuclear-Targeted Drug Delivery by Dual-Ligand-Modified Mesoporous Silica Nanoparticles. , 2015, Small.

[11]  Chun‐Sing Lee,et al.  Graphitic carbon nitride nanosheet@metal-organic framework core-shell nanoparticles for photo-chemo combination therapy. , 2015, Nanoscale.

[12]  Peter K. N. Yu,et al.  Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo. , 2015, ACS nano.

[13]  Xianfeng Chen,et al.  Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance. , 2015, Chemical communications.

[14]  Liangzhu Feng,et al.  Drug-Induced Self-Assembly of Modified Albumins as Nano-theranostics for Tumor-Targeted Combination Therapy. , 2015, ACS nano.

[15]  C. Weng,et al.  Layered double hydroxide nanoparticles to enhance organ-specific targeting and the anti-proliferative effect of cisplatin. , 2015, Journal of materials chemistry. B.

[16]  Xian Chen,et al.  Photon upconversion in core-shell nanoparticles. , 2015, Chemical Society reviews.

[17]  Youyong Li,et al.  Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer , 2015, Nano Research.

[18]  J. Atherton,et al.  Hierarchical layered double hydroxide nanocomposites: structure, synthesis and applications. , 2015, Chemical communications.

[19]  Li Li,et al.  Amine-functionalized SiO2 nanodot-coated layered double hydroxide nanocomposites for enhanced gene delivery , 2015, Nano Research.

[20]  T. Prow,et al.  Enhanced delivery of nano- and submicron particles using elongated microparticles. , 2015, Current drug delivery.

[21]  Yousuf H. Mohammed,et al.  Polarized immune responses modulated by layered double hydroxides nanoparticle conjugated with CpG. , 2014, Biomaterials.

[22]  Chun-Sing Lee,et al.  Micro- and nanotechnologies for intracellular delivery. , 2014, Small.

[23]  W. Li,et al.  Functional Core/Shell Drug Nanoparticles for Highly Effective Synergistic Cancer Therapy , 2014, Advanced healthcare materials.

[24]  G. Qian,et al.  Quick and efficient co-treatment of Zn(2+)/Ni(2+) and CN(-) via the formation of Ni(CN)4(2-) intercalated larger ZnAl-LDH crystals. , 2014, Journal of hazardous materials.

[25]  Chun‐Sing Lee,et al.  A graphene quantum dot photodynamic therapy agent with high singlet oxygen generation , 2014, Nature Communications.

[26]  Yang Yang,et al.  Advanced Materials and Nanotechnology for Drug Delivery , 2014, Advanced materials.

[27]  Xianfeng Chen,et al.  Novel Pt-loaded layered double hydroxide nanoparticles for efficient and cancer-cell specific delivery of a cisplatin prodrug. , 2014, Journal of materials chemistry. B.

[28]  Jiansheng Jie,et al.  Smart Nanorods for Highly Effective Cancer Theranostic Applications , 2014, Advanced healthcare materials.

[29]  Min Wei,et al.  A Supermolecular Photosensitizer with Excellent Anticancer Performance in Photodynamic Therapy , 2014 .

[30]  Xianfeng Chen,et al.  Highly luminescent covalently bonded layered double hydroxide–fluorescent dye nanohybrids , 2014 .

[31]  Tarl W Prow,et al.  Nanocomposite‐Strengthened Dissolving Microneedles for Improved Transdermal Delivery to Human Skin , 2014, Advanced healthcare materials.

[32]  Zhi Ping Xu,et al.  Co-delivery of siRNAs and anti-cancer drugs using layered double hydroxide nanoparticles. , 2014, Biomaterials.

[33]  Zhuang Liu,et al.  PEG-functionalized iron oxide nanoclusters loaded with chlorin e6 for targeted, NIR light induced, photodynamic therapy. , 2013, Biomaterials.

[34]  Zhuang Liu,et al.  Carrier-free functionalized multidrug nanorods for synergistic cancer therapy. , 2013, Biomaterials.

[35]  Wei Chen,et al.  Folic acid conjugated self-assembled layered double hydroxide nanoparticles for high-efficacy-targeted drug delivery. , 2013, Chemical communications.

[36]  W. Li,et al.  Shape design of high drug payload nanoparticles for more effective cancer therapy. , 2013, Chemical communications.

[37]  Jinfeng Zhang,et al.  Simultaneous enhanced diagnosis and photodynamic therapy of photosensitizer-doped perylene nanoparticles via doping, fluorescence resonance energy transfer, and antenna effect. , 2013, Chemical communications.

[38]  Jian Liu,et al.  Enzyme-responsive controlled release of covalently bound prodrug from functional mesoporous silica nanospheres. , 2012, Angewandte Chemie.

[39]  Xing-jie Liang,et al.  Biomedical nanomaterials for imaging-guided cancer therapy. , 2012, Nanoscale.

[40]  Julie H. Campbell,et al.  Antibody‐Targeted Drug Delivery to Injured Arteries Using Layered Double Hydroxide Nanoparticles , 2012, Advanced healthcare materials.

[41]  Zhuang Liu,et al.  Carrier-free, water dispersible and highly luminescent dye nanoparticles for targeted cell imaging. , 2012, Nanoscale.

[42]  Z. Dai,et al.  Conjugation of porphyrin to nanohybrid cerasomes for photodynamic diagnosis and therapy of cancer. , 2011, Angewandte Chemie.

[43]  G. Lu,et al.  Synthesis of nanorattles with layered double hydroxide core and mesoporous silica shell as delivery vehicles , 2011 .

[44]  Corona M. Cassidy,et al.  Delivery of photosensitisers and light through mucus: investigations into the potential use of photodynamic therapy for treatment of Pseudomonas aeruginosa cystic fibrosis pulmonary infection. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[45]  Z. Xu,et al.  Stabilization of layered double hydroxide nanoparticles by bovine serum albumin pre-coating for drug/gene delivery. , 2015, Journal of controlled release : official journal of the Controlled Release Society.

[46]  Yann-C. Li,et al.  Rectangular-plate like organosilica microcrystals based on silylated β-diketone and lanthanide ions , 2011 .

[47]  G. Lu,et al.  Stable suspension of layered double hydroxide nanoparticles in aqueous solution. , 2006, Journal of the American Chemical Society.