ATP-Dependent Chromatin Remodeling and DNA Double-Strand Break Repair

The repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genomic stability. Two pathways for the repair of DBSs, non-homologous end-joining (NHEJ) and homologous recombination (HR), have evolved in eukaryotes. These pathways, like processes such as transcription and replication, act on DNA that is embedded in nucleosomes. Recent studies have shown that DNA repair, like transcription, is facilitated both by histone tail modification and by ATP-dependent chromatin remodeling. This review emphasizes recent reports that demonstrate a function for the ATP-dependent chromatin remodeling complexes INO80 and RSC in NHEJ and HR. We also discuss the possible role of SWR1- and TIP60-mediated nucleosomal histone exchange in DNA repair.

[1]  Huiming Ding,et al.  A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. , 2003, Molecular cell.

[2]  Kunihiro Matsumoto,et al.  Recruitment of Mec1 and Ddc1 Checkpoint Proteins to Double-Strand Breaks Through Distinct Mechanisms , 2001, Science.

[3]  S. Jackson,et al.  Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. , 2004, Molecular cell.

[4]  B. Cairns,et al.  A Rsc3/Rsc30 zinc cluster dimer reveals novel roles for the chromatin remodeler RSC in gene expression and cell cycle control. , 2001, Molecular cell.

[5]  M. Resnick,et al.  Genes required for ionizing radiation resistance in yeast , 2001, Nature Genetics.

[6]  Stephen P. Jackson,et al.  A role for Saccharomyces cerevisiae histone H2A in DNA repair , 2000, Nature.

[7]  Sophie G. Martin,et al.  Relocalization of Telomeric Ku and SIR Proteins in Response to DNA Strand Breaks in Yeast , 1999, Cell.

[8]  Michael Lichten,et al.  Distribution and Dynamics of Chromatin Modification Induced by a Defined DNA Double-Strand Break , 2004, Current Biology.

[9]  John Rouse,et al.  Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. , 2002, Molecular cell.

[10]  James T Kadonaga,et al.  Chromatin remodeling by ATP-dependent molecular machines. , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[11]  Ali Hamiche,et al.  A chromatin remodelling complex involved in transcription and DNA processing , 2000, Nature.

[12]  Michael Lichten,et al.  DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. , 2004, Molecular cell.

[13]  K. Shirahige,et al.  Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair. , 2004, Molecular cell.

[14]  J. Hoeijmakers,et al.  Chromosomal stability and the DNA double-stranded break connection , 2001, Nature Reviews Genetics.

[15]  S. Kron,et al.  NuA4 Subunit Yng2 Function in Intra-S-Phase DNA Damage Response , 2002, Molecular and Cellular Biology.

[16]  N. Krogan,et al.  INO80 and γ-H2AX Interaction Links ATP-Dependent Chromatin Remodeling to DNA Damage Repair , 2004, Cell.

[17]  John R Yates,et al.  Acetylation by Tip60 Is Required for Selective Histone Variant Exchange at DNA Lesions , 2004, Science.

[18]  K. Miyahara,et al.  Abundance of the RSC nucleosome‐remodeling complex is important for the cells to tolerate DNA damage in Saccharomyces cerevisiae , 2002, FEBS letters.

[19]  Nevan J Krogan,et al.  INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. , 2004, Cell.

[20]  G. Benvenuto,et al.  The INO80 protein controls homologous recombination in Arabidopsis thaliana. , 2004, Molecular cell.

[21]  Sang Eun Lee,et al.  The Yeast Chromatin Remodeler RSC Complex Facilitates End Joining Repair of DNA Double-Strand Breaks , 2005, Molecular and Cellular Biology.

[22]  Jun Qin,et al.  Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis , 2000, Cell.

[23]  Wei-Hua Wu,et al.  ATP-Driven Exchange of Histone H2AZ Variant Catalyzed by SWR1 Chromatin Remodeling Complex , 2004, Science.

[24]  Carl Wu,et al.  Involvement of actin-related proteins in ATP-dependent chromatin remodeling. , 2003, Molecular cell.

[25]  Jian Huang,et al.  The RSC nucleosome-remodeling complex is required for Cohesin's association with chromosome arms. , 2004, Molecular cell.

[26]  D. Toczyski,et al.  Two checkpoint complexes are independently recruited to sites of DNA damage in vivo. , 2001, Genes & development.

[27]  S. West,et al.  ATP-dependent branch migration of holliday junctions promoted by the RuvA and RuvB proteins of E. coli , 1992, Cell.

[28]  Andrew J Link,et al.  A Protein Complex Containing the Conserved Swi2/Snf2-Related ATPase Swr1p Deposits Histone Variant H2A.Z into Euchromatin , 2004, PLoS biology.

[29]  A. Taylor,et al.  Specific Recruitment of Human Cohesin to Laser-induced DNA Damage* , 2002, The Journal of Biological Chemistry.

[30]  Alexander W. Bird,et al.  Acetylation of histone H4 by Esa1 is required for DNA double-strand break repair , 2002, Nature.

[31]  Michael Grunstein,et al.  Histone acetylation and deacetylation in yeast , 2003, Nature Reviews Molecular Cell Biology.

[32]  Kunihiro Matsumoto,et al.  ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. , 2003, Genes & development.

[33]  C. Peterson,et al.  Cellular machineries for chromosomal DNA repair. , 2004, Genes & development.

[34]  Barbara Hohn,et al.  Recruitment of the INO80 Complex by H2A Phosphorylation Links ATP-Dependent Chromatin Remodeling with DNA Double-Strand Break Repair , 2004, Cell.

[35]  K. Nasmyth,et al.  Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae , 2001, Current Biology.

[36]  Jacques Côté,et al.  The highly conserved and multifunctional NuA4 HAT complex. , 2004, Current opinion in genetics & development.