Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation.

[1]  J. Boothroyd,et al.  Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence , 2011, Proceedings of the National Academy of Sciences.

[2]  Julia P. Hunn,et al.  Faculty Opinions recommendation of Strain-specific activation of the NF-kappaB pathway by GRA15, a novel Toxoplasma gondii dense granule protein. , 2011 .

[3]  J. Saeij,et al.  Strain-specific activation of the NF-κB pathway by GRA15, a novel Toxoplasma gondii dense granule protein , 2011, The Journal of experimental medicine.

[4]  Michael S. Behnke,et al.  Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. , 2010, Cell host & microbe.

[5]  L. Sibley,et al.  Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii , 2010, PLoS biology.

[6]  A. Mantovani,et al.  Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm , 2010, Nature Immunology.

[7]  D. Roos,et al.  Virulence of Toxoplasma gondii Is Associated with Distinct Dendritic Cell Responses and Reduced Numbers of Activated CD8+ T Cells , 2010, The Journal of Immunology.

[8]  J. Boothroyd,et al.  Toxoplasma Rhoptry Protein 16 (ROP16) Subverts Host Function by Direct Tyrosine Phosphorylation of STAT6* , 2010, The Journal of Biological Chemistry.

[9]  C. Loddenkemper,et al.  Interleukin (IL)-23 mediates Toxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17 , 2009, The Journal of experimental medicine.

[10]  Ruslan Medzhitov,et al.  Transcriptional control of the inflammatory response , 2009, Nature Reviews Immunology.

[11]  D. Roos,et al.  Dynamic Imaging of CD8+ T Cells and Dendritic Cells during Infection with Toxoplasma gondii , 2009, PLoS pathogens.

[12]  A. Smith,et al.  Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis , 2009, PLoS pathogens.

[13]  S. Gordon,et al.  Alternative activation of macrophages: an immunologic functional perspective. , 2009, Annual review of immunology.

[14]  E. Denkers,et al.  Dendritic Cells Expressing Plasmacytoid Marker PDCA-1 Are Trojan Horses during Toxoplasma gondii Infection1 , 2008, The Journal of Immunology.

[15]  G. Kaplan,et al.  Toll-like receptor–induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens , 2008, Nature Immunology.

[16]  J. Ajioka,et al.  Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. , 2008, Annual review of microbiology.

[17]  L. Sibley,et al.  Gr1(+) inflammatory monocytes are required for mucosal resistance to the pathogen Toxoplasma gondii. , 2008, Immunity.

[18]  Frank Brombacher,et al.  Macrophage-specific PPARγ controls alternative activation and improves insulin resistance , 2007, Nature.

[19]  D. Roos,et al.  Divergent polyamine metabolism in the Apicomplexa. , 2007, Microbiology.

[20]  J. Boothroyd,et al.  Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue , 2007, Nature.

[21]  J. Ajioka,et al.  Polymorphic Secreted Kinases Are Key Virulence Factors in Toxoplasmosis , 2006, Science.

[22]  Michael S. Behnke,et al.  A Secreted Serine-Threonine Kinase Determines Virulence in the Eukaryotic Pathogen Toxoplasma gondii , 2006, Science.

[23]  Alberto Mantovani,et al.  Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression1 , 2006, The Journal of Immunology.

[24]  L. Hennighausen,et al.  Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system , 2006, Nature Immunology.

[25]  K. Heeg,et al.  Induction of Suppressor of Cytokine Signaling-1 by Toxoplasma gondii Contributes to Immune Evasion in Macrophages by Blocking IFN-γ Signaling1 , 2006, The Journal of Immunology.

[26]  A. Kaur,et al.  The evolution of vertebrate Toll-like receptors. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[27]  J. Andersen,et al.  TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein , 2005, Science.

[28]  S. Akira,et al.  Production of IL-12 by Macrophages Infected with Toxoplasma gondii Depends on the Parasite Genotype1 , 2004, The Journal of Immunology.

[29]  L. Sibley,et al.  A novel population of Gr‐1+‐activated macrophages induced during acute toxoplasmosis , 2003, Journal of leukocyte biology.

[30]  J. Boothroyd,et al.  Population biology of Toxoplasma gondii and its relevance to human infection: do different strains cause different disease? , 2002, Current opinion in microbiology.

[31]  P. Pavlidis,et al.  Cutting Edge: STAT6 Serves as a Positive and Negative Regulator of Gene Expression in IL-4-Stimulated B Lymphocytes1 , 2002, The Journal of Immunology.

[32]  L. Sibley,et al.  Acute Toxoplasmosis Leads to Lethal Overproduction of Th1 Cytokines1 , 2001, The Journal of Immunology.

[33]  J. Boothroyd,et al.  Unusual abundance of atypical strains associated with human ocular toxoplasmosis. , 2001, The Journal of infectious diseases.

[34]  V. Iniesta,et al.  The Inhibition of Arginase by N ω-Hydroxy-l-Arginine Controls the Growth of Leishmania Inside Macrophages , 2001, The Journal of experimental medicine.

[35]  Kristi Kincaid,et al.  M-1/M-2 Macrophages and the Th1/Th2 Paradigm1 , 2000, The Journal of Immunology.

[36]  A. Sher,et al.  Inducible Nitric Oxide Is Essential for Host Control of Persistent but Not Acute Infection with the Intracellular Pathogen Toxoplasma gondii , 1997, The Journal of experimental medicine.

[37]  K. Rock,et al.  Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. , 1997, Journal of immunology.

[38]  Y. Suzuki,et al.  Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii , 1996, The Journal of experimental medicine.

[39]  A. Sher,et al.  In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha. , 1996, Journal of immunology.

[40]  C. Roberts,et al.  Different roles for interleukin-4 during the course of Toxoplasma gondii infection , 1996, Infection and immunity.

[41]  M. Modolell,et al.  Determination of arginase activity in macrophages: a micromethod. , 1994, Journal of immunological methods.

[42]  Yasuhiro Suzuki,et al.  Effect of the strain ofToxoplasma gondii on the development of toxoplasmic encephalitis in mice treated with antibody to interferon-gamma , 2004, Parasitology Research.

[43]  S. Gordon Alternative activation of macrophages , 2003, Nature Reviews Immunology.