Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

[1]  Rakesh Kumar,et al.  Structure, biochemistry, and biology of PAK kinases. , 2017, Gene.

[2]  H. Kocher,et al.  PAK4 interacts with p85 alpha: implications for pancreatic cancer cell migration , 2017, Scientific Reports.

[3]  A. Azmi,et al.  Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma , 2016, Molecular Cancer Therapeutics.

[4]  W. Han,et al.  Pancreatic regulation of glucose homeostasis , 2016, Experimental & Molecular Medicine.

[5]  A. Singh,et al.  p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling , 2015, Cancer letters.

[6]  G. Baldwin,et al.  The role of p21-activated kinases in pancreatic cancer. , 2015, Pancreas.

[7]  J. W. Kim,et al.  p21-Activated Kinase 4 (PAK4) as a Predictive Marker of Gemcitabine Sensitivity in Pancreatic Cancer Cell Lines , 2014, Cancer research and treatment : official journal of Korean Cancer Association.

[8]  A. Singh,et al.  p-21 activated kinase 4 promotes proliferation and survival of pancreatic cancer cells through AKT- and ERK-dependent activation of NF-κB pathway , 2014, Oncotarget.

[9]  M. Boermeester,et al.  Treatment options for acute pancreatitis , 2014, Nature Reviews Gastroenterology &Hepatology.

[10]  D. Whitcomb,et al.  Genetics and Treatment Options for Recurrent Acute and Chronic Pancreatitis , 2014, Current Treatment Options in Gastroenterology.

[11]  Michelle Jobes,et al.  Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight , 2014, Nutritional neuroscience.

[12]  A. Minden,et al.  P21 activated kinases , 2014, Small GTPases.

[13]  J. Chernoff,et al.  PAK signalling during the development and progression of cancer , 2013, Nature Reviews Cancer.

[14]  Zhengping Jia,et al.  Pak3 Promotes Cell Cycle Exit and Differentiation of β-Cells in the Embryonic Pancreas and Is Necessary to Maintain Glucose Homeostasis in Adult Mice , 2013, Diabetes.

[15]  Michelle Jobes,et al.  Functional Deficits in Pak5, Pak6 and Pak5/Pak6 Knockout Mice , 2013, PloS one.

[16]  A. Dart,et al.  P21-activated kinase 4--not just one of the PAK. , 2013, European journal of cell biology.

[17]  A. Minden,et al.  Role for p21-activated kinase PAK4 in development of the mammalian heart , 2012, Transgenic Research.

[18]  J. Chernoff,et al.  Mouse models of PAK function , 2012, Cellular logistics.

[19]  J. Chernoff,et al.  Inhibition or Ablation of p21-activated Kinase (PAK1) Disrupts Glucose Homeostatic Mechanisms in Vivo* , 2011, The Journal of Biological Chemistry.

[20]  上田 裕紀.  Etiology of type 1 diabetes , 2011 .

[21]  A. Minden,et al.  A key role for Pak4 in proliferation and differentiation of neural progenitor cells. , 2011, Developmental biology.

[22]  S. Strömblad,et al.  Integrin-mediated Cell Attachment Induces a PAK4-dependent Feedback Loop Regulating Cell Adhesion through Modified Integrin αvβ5 Clustering and Turnover , 2010, Molecular biology of the cell.

[23]  N. Morin,et al.  Subgroup II PAK-mediated phosphorylation regulates Ran activity during mitosis , 2010, The Journal of cell biology.

[24]  M. Thullberg,et al.  p21-activated Kinase 4 Phosphorylation of Integrin β5 Ser-759 and Ser-762 Regulates Cell Migration* , 2010, The Journal of Biological Chemistry.

[25]  J. Masters,et al.  PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion , 2010, Journal of Cell Science.

[26]  M. Hara,et al.  Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition , 2010, Islets.

[27]  P. Herrera,et al.  Pancreatic neurogenin 3-expressing cells are unipotent islet precursors , 2009, Development.

[28]  A. Minden,et al.  Essential role for the Pak4 protein kinase in extraembryonic tissue development and vessel formation , 2009, Mechanisms of Development.

[29]  J. Travers,et al.  p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. , 2009, Blood.

[30]  Gerald C. Chu,et al.  Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer , 2008, Proceedings of the National Academy of Sciences.

[31]  J. Kendall,et al.  Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification , 2008, Cancer biology & therapy.

[32]  Michelle Jobes,et al.  Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion. , 2008, Developmental biology.

[33]  Luis E. Arias-Romero,et al.  A tale of two Paks , 2008, Biology of the cell.

[34]  Jinsong Meng,et al.  Abnormal Long-Lasting Synaptic Plasticity and Cognition in Mice Lacking the Mental Retardation Gene Pak3 , 2005, The Journal of Neuroscience.

[35]  E. Petricoin,et al.  Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. , 2003, Cancer cell.

[36]  R. Bronson,et al.  PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development , 2003, Molecular and Cellular Biology.

[37]  A. Minden,et al.  Targeted Disruption of the Gene for the PAK5 Kinase in Mice , 2003, Molecular and Cellular Biology.

[38]  J. Holst,et al.  Lower blood glucose, hyperglucagonemia, and pancreatic α cell hyperplasia in glucagon receptor knockout mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[39]  R. DePinho,et al.  Pancreatic cancer biology and genetics , 2002, Nature Reviews Cancer.

[40]  O. Bernard,et al.  Cytoskeletal Changes Regulated by the PAK4 Serine/Threonine Kinase Are Mediated by LIM Kinase 1 and Cofilin* , 2001, The Journal of Biological Chemistry.

[41]  N. Gnesutta,et al.  The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis* , 2001, The Journal of Biological Chemistry.

[42]  S. P. Grossman.  The role of glucose, insulin and glucagon in the regulation of food intake and body weight , 1986, Neuroscience & Biobehavioral Reviews.

[43]  C. Wells,et al.  Role of p-21-activated kinases in cancer progression. , 2014, International review of cell and molecular biology.