Superthreshold Behavior of Ultrasound‐Induced Lung Hemorrhage in Adult Rats

The purpose of this study was to augment and reevaluate the ultrasound‐induced lung hemorrhage findings of a previous 5 × 3 factorial design study (Ultrasound Med Biol 2001; 27:267–277) that evaluated the role of pulse repetition frequency (PRF: 25, 50, 100, 250, and 500 Hz) and exposure duration (ED; 5, 10, and 20 s) on ultrasound‐induced lung hemorrhage at an in situ (at the pleural surface) peak rarefactional pressure [pr(in situ)] of 12.3 MPa; only PRF was found to be significant. However, saturation (response plateau) due to the high pr(in situ) might have skewed the results. In this follow‐up 3 × 3 factorial design study, a wider range of PRFs and EDs were used at a lower pr(in situ).

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