Clinical Application of Thromboelastography in Patients With Severe Fever With Thrombocytopenia Syndrome

Aim To investigate the clinical application of thromboelastography (TEG) in severe fever with thrombocytopenia syndrome (SFTS). Methods One hundred and fifty-seven patients with SFTS were included in the study. The participants were distributed into 3 groups; A, B, and C. And 103 patients in group A met the clinical criteria as they exhibited slight liver and kidney dysfunction. Group B consisted of 54 patients with SFTS who were critically ill while group C was a healthy control group with 58 participants. Results Patients with SFTS exhibited lower coagulation than the healthy participants. Group B patients exhibited significantly lower coagulation compared to group A. There was no significant difference in platelet count and fibrinogen content between patients in group A and group B, but platelet aggregation function and fibrinogen activity were significantly lower in group B patients. Conclusion Our results suggest that it is risky to solely rely on platelet count and the fibrinogen in SFTS. Monitoring of TEG and other coagulation indexes should be emphasized.

[1]  Zhihang Peng,et al.  Epidemiological and clinical characteristics of severe fever with thrombocytopenia syndrome bunyavirus human-to-human transmission , 2021, PLoS neglected tropical diseases.

[2]  Y. Liu,et al.  Thromboelastography (TEG) in normal pregnancy and its diagnostic efficacy in patients with gestational hypertension, gestational diabetes mellitus, or preeclampsia , 2020, Journal of clinical laboratory analysis.

[3]  Yuanhong Xu,et al.  Severe fever with thrombocytopenia syndrome in Hefei: Clinical features, risk factors, and ribavirin therapeutic efficacy , 2020, Journal of medical virology.

[4]  Bian-Li Xu,et al.  Severe fever with thrombocytopenia syndrome: a systematic review and meta-analysis of epidemiology, clinical signs, routine laboratory diagnosis, risk factors, and outcomes , 2020, BMC Infectious Diseases.

[5]  D. S. Morris,et al.  Platelet dysfunction on thromboelastogram is associated with severity of blunt traumatic brain injury. , 2019, American journal of surgery.

[6]  M. Ono,et al.  Comparison of two point of care whole blood coagulation analysis devices and conventional coagulation tests as a predicting tool of perioperative bleeding in adult cardiac surgery—a pilot prospective observational study in Japan , 2019, Transfusion.

[7]  S. Hota,et al.  Thromboelastogram-Guided Resuscitation for Patients with Traumatic Brain Injury on Novel Anticoagulants , 2019, The American surgeon.

[8]  K. Morita,et al.  Viral load and inflammatory cytokine dynamics associated with the prognosis of severe fever with thrombocytopenia syndrome virus infection: An autopsy case. , 2019, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[9]  Mao-lin Huang,et al.  Preexisting chronic conditions for fatal outcome among SFTS patients: An observational Cohort Study , 2019, PLoS neglected tropical diseases.

[10]  Jinhe Kim,et al.  An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus , 2018, bioRxiv.

[11]  Sung‐Han Kim,et al.  Case Report: Use of Plasma Exchange Followed by Convalescent Plasma Therapy in a Critically Ill Patient with Severe Fever and Thrombocytopenia Syndrome-Associated Encephalopathy: Cytokine/Chemokine Concentrations, Viral Loads, and Antibody Responses. , 2018, The American journal of tropical medicine and hygiene.

[12]  Lei Wang,et al.  Comparison Between Thromboelastography and Conventional Coagulation Tests in Surgical Patients With Localized Prostate Cancer , 2018, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.

[13]  H. Hunger,et al.  EDITION , 2018, Moshe Bar Kepha's Commentary on the Gospel of Luke.

[14]  Hui-qin Wen,et al.  Reference values for kaolin‐activated thromboelastography in volunteers of Anhui Province in China , 2017, Journal of clinical laboratory analysis.

[15]  F. Zhan,et al.  Current status of severe fever with thrombocytopenia syndrome in China , 2017, Virologica Sinica.

[16]  Qiyong Liu,et al.  Factors associated with Severe Fever with Thrombocytopenia Syndrome infection and fatal outcome , 2016, Scientific Reports.

[17]  L. Fang,et al.  A National Assessment of the Epidemiology of Severe Fever with Thrombocytopenia Syndrome, China , 2015, Scientific Reports.

[18]  G. Lippi,et al.  Aging Hemostasis: Changes to Laboratory Markers of Hemostasis As We Age—A Narrative Review , 2014, Seminars in Thrombosis & Hemostasis.

[19]  F. Ding,et al.  Seroprevalence of severe fever with thrombocytopenia syndrome virus in southeastern China and analysis of risk factors , 2014, Epidemiology and Infection.

[20]  Weizhong Yang,et al.  Fever with thrombocytopenia associated with a novel bunyavirus in China. , 2011, The New England journal of medicine.

[21]  W. Muntean,et al.  Age-dependency of thrombin generation measured by means of calibrated automated thrombography (CAT) , 2006, Thrombosis and Haemostasis.

[22]  W. Liu,et al.  Clinical progression and predictors of death in patients with severe fever with thrombocytopenia syndrome in China. , 2014, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.