Hotspots for Emerging Epidemics: Multi-Task and Transfer Learning over Mobility Networks

Emerging epidemics such as the COVID-19 entail economic and social challenges, which require immediate attention from policymakers. An essential building block towards the implementation of mitigation policies (e.g., lockdown and testing) is the identification of potential hotspots, defined as areas that contribute significantly to the spatial diffusion of infections. This work seeks to identify these hotspots for emerging epidemics through advanced analytical methodologies, i.e., a combination of long short-term memory (LSTM) model, multi-task learning, and transfer learning. To achieve this goal, we use data on COVID-19 infections and mobility over a network of locations to illustrate the proposed method. We first identify transmission hotspots by employing the LSTM model together with multi-task learning over a network of locations. Next, to illustrate the importance of these identified hotspots in deciding on lockdown policies, we compare the transmission hotspots-based policy with a pure infection load-based policy and show the hotspots-based policy leads to a 21% improvement in reducing the predicted new infections. Finally, we improve our hotspots identification with transfer learning from past influenza transmission data. We demonstrate that the inclusion of transfer learning reduces the mean absolute error in the infection prediction by 53.4% and consequently improves the hotspots identification. On a broader note, this paper proposes an advanced data-driven approach to identify transmission hotspots, which has considerable methodological and practical implications for the current and any future pandemic if one were to occur.

[1]  Yiu Chung Lau,et al.  Temporal dynamics in viral shedding and transmissibility of COVID-19 , 2020, Nature Medicine.

[2]  Su Ruan,et al.  Multi-task deep learning based CT imaging analysis for COVID-19 pneumonia: Classification and segmentation , 2020, Computers in Biology and Medicine.

[3]  Stefan Spinler,et al.  Spatial Resource Allocation for Emerging Epidemics: A Comparison of Greedy, Myopic, and Dynamic Policies , 2018, Manuf. Serv. Oper. Manag..

[4]  R. Turner,et al.  Comparison of influenza type A and B with COVID‐19: A global systematic review and meta‐analysis on clinical, laboratory and radiographic findings , 2020, Reviews in medical virology.

[5]  I. Torres,et al.  Localising an asset-based COVID-19 response in Ecuador , 2020, The Lancet.

[6]  Roberto Cipolla,et al.  Multi-task Learning Using Uncertainty to Weigh Losses for Scene Geometry and Semantics , 2017, 2018 IEEE/CVF Conference on Computer Vision and Pattern Recognition.

[7]  Qiang Yang,et al.  Multitask Learning for Protein Subcellular Location Prediction , 2011, IEEE/ACM Transactions on Computational Biology and Bioinformatics.

[8]  Xiangyan Tang,et al.  An Improved Method for the Fitting and Prediction of the Number of COVID-19 Confirmed Cases Based on LSTM , 2020, Computers, Materials & Continua.

[9]  A. Terasmaa,et al.  Liraglutide, 7,8-DHF and their co-treatment prevents loss of vision and cognitive decline in a Wolfram syndrome rat model , 2021, Scientific Reports.

[10]  Christopher S. Tang,et al.  Rapid Development of a Decision Support System to Alleviate Food Insecurity at the Los Angeles Regional Food Bank amid the COVID‐19 Pandemic , 2021 .

[11]  Aneela Zameer,et al.  Predictions for COVID-19 with deep learning models of LSTM, GRU and Bi-LSTM , 2020, Chaos, Solitons & Fractals.

[12]  Nuno Ferreira,et al.  Estimation of risk factors for COVID-19 mortality - preliminary results , 2020, medRxiv.

[13]  Boris Simovski,et al.  Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2: toward universal blueprints for vaccine designs , 2020, bioRxiv.

[14]  G. Rodier,et al.  Hot spots in a wired world: WHO surveillance of emerging and re-emerging infectious diseases. , 2001, The Lancet. Infectious diseases.

[15]  Azita G. Hamedani,et al.  Established and Novel Initiatives to Reduce Crowding in Emergency Departments , 2013, The western journal of emergency medicine.

[16]  Xuanjing Huang,et al.  Deep Multi-Task Learning with Shared Memory for Text Classification , 2016, EMNLP.

[17]  Daron Acemoglu,et al.  Testing, Voluntary Social Distancing and the Spread of an Infection , 2020, Operations Research.

[18]  Nino Antulov-Fantulin,et al.  Exploring Interpretable LSTM Neural Networks over Multi-Variable Data , 2019, ICML.

[19]  Guihua Wang Stay at Home to Stay Safe: Effectiveness of Stay-at-Home Orders in Containing the COVID-19 Pandemic , 2020 .

[20]  Sridhar Seshadri,et al.  Evaluation of reopening strategies for educational institutions during COVID-19 through agent based simulation , 2021, Scientific reports.

[21]  M. Hernán,et al.  Prevalence of SARS-CoV-2 in Spain (ENE-COVID): a nationwide, population-based seroepidemiological study , 2020, The Lancet.

[22]  David A. Drew,et al.  Detecting COVID-19 infection hotspots in England using large-scale self-reported data from a mobile application: a prospective, observational study , 2020, The Lancet Public Health.

[23]  G. Borjas,et al.  Demographic Determinants of Testing Incidence and Covid-19 Infections in New York City Neighborhoods , 2020, SSRN Electronic Journal.

[24]  S. Pokharel Wisdom of Crowds: The Value of Stock Opinions Transmitted through Social Media , 2014 .

[25]  Z. Memish,et al.  Covid-19 and community mitigation strategies in a pandemic , 2020, BMJ.

[26]  M. Brandeau,et al.  Resource allocation for control of infectious diseases in multiple independent populations: beyond cost-effectiveness analysis. , 2003, Journal of health economics.

[27]  S. Pei,et al.  Differential effects of intervention timing on COVID-19 spread in the United States , 2020, Science Advances.

[28]  Jenna Wiens,et al.  Deep Multi-Output Forecasting: Learning to Accurately Predict Blood Glucose Trajectories , 2018, KDD.

[29]  Shotaro Minami,et al.  Predicting Equity Price with Corporate Action Events Using LSTM-RNN , 2018 .

[30]  Jürgen Schmidhuber,et al.  LSTM: A Search Space Odyssey , 2015, IEEE Transactions on Neural Networks and Learning Systems.

[31]  Benjamin J. Cowling,et al.  Respiratory virus shedding in exhaled breath and efficacy of face masks , 2020, Nature Medicine.

[32]  Annamária R. Várkonyi-Kóczy,et al.  COVID-19 Outbreak Prediction with Machine Learning , 2020, Algorithms.

[33]  Alex Sherstinsky,et al.  Fundamentals of Recurrent Neural Network (RNN) and Long Short-Term Memory (LSTM) Network , 2018, Physica D: Nonlinear Phenomena.

[34]  Hamsa Bastani Predicting with Proxies: Transfer Learning in High Dimension , 2018 .

[35]  Alan Scheller-Wolf,et al.  Product Portfolio Restructuring: Methodology and Application at Caterpillar , 2018 .

[36]  Michael Y. Li,et al.  Why is it difficult to accurately predict the COVID-19 epidemic? , 2020, Infectious Disease Modelling.

[37]  A. Gundlapalli,et al.  Timing of State and Territorial COVID-19 Stay-at-Home Orders and Changes in Population Movement — United States, March 1–May 31, 2020 , 2020, MMWR. Morbidity and mortality weekly report.

[38]  C. Schwartz,et al.  Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression , 2020, Nature Communications.

[39]  From predictions to prescriptions: A data-driven response to COVID-19 , 2021, Health care management science.

[40]  Ding Ma,et al.  Machine learning based early warning system enables accurate mortality risk prediction for COVID-19 , 2020, Nature Communications.

[41]  Tangchun Wu,et al.  Reconstruction of the full transmission dynamics of COVID-19 in Wuhan , 2020, Nature.

[42]  Yogesh Gautam Transfer Learning for COVID-19 cases and deaths forecast using LSTM network , 2021, ISA Transactions.

[43]  Joelle Pineau,et al.  Machine Learning for COVID-19 needs global collaboration and data-sharing , 2020, Nat. Mach. Intell..

[44]  Parvin Mousavi,et al.  Generalizable deep temporal models for predicting episodes of sudden hypotension in critically ill patients: a personalized approach , 2020, Scientific Reports.

[45]  Caroline O Buckee,et al.  The use of mobile phone data to inform analysis of COVID-19 pandemic epidemiology , 2020, Nature Communications.

[46]  Boris Simovski,et al.  Artificial intelligence predicts the immunogenic landscape of SARS-CoV-2: toward universal blueprints for vaccine designs , 2020 .

[47]  H. C. Ozmutlu,et al.  Scheduling Methods for Efficient Stamping Operations at an Automotive Company , 2016 .

[48]  Roland Bouffanais,et al.  Cities — try to predict superspreading hotspots for COVID-19 , 2020, Nature.

[49]  P. De,et al.  Wisdom of Crowds: The Value of Stock Opinions Transmitted Through Social Media , 2013 .

[50]  M. Ritchey,et al.  Association Between Social Vulnerability and a County’s Risk for Becoming a COVID-19 Hotspot — United States, June 1–July 25, 2020 , 2020, MMWR. Morbidity and mortality weekly report.

[51]  Chelliah Sriskandarajah,et al.  Scheduling Elective Surgeries with Emergency Patients at Shared Operating Rooms , 2019, Production and Operations Management.

[52]  Christophe Fraser,et al.  Assessment of epidemic projections using recent HIV survey data in South Africa: a validation analysis of ten mathematical models of HIV epidemiology in the antiretroviral therapy era. , 2015, The Lancet. Global health.

[53]  Sharareh R Niakan Kalhori,et al.  Predicting COVID-19 Incidence Through Analysis of Google Trends Data in Iran: Data Mining and Deep Learning Pilot Study , 2020, JMIR Public Health and Surveillance.