Cholecystokinin in the cat retina. Action of exogenous CCK8 and localization of cholecystokinin-like immunoreactivity.

The effects of applying cholecystokinin (CCK8) iontophoretically onto cat retinal ganglion cells were studied in the optically intact eye of the cat. CCK8 suppressed both the maintained and the light evoked discharge of brisk ganglion cells, irrespective of their being on- or off-center, brisk-transient, or brisk-sustained and independent of the state of light adaptation. The inhibitory action of CCK8 in the cat retina is opposite from its excitatory action in other parts of the brain. Using an antiserum to cholecystokinin, immunoreactivity was localized in horizontal cells and amacrine cells of the cat retina. Inconsistently immunoreactivity also was found in ganglion cells and fibers.

[1]  K. Uchizono.  Characteristics of Excitatory and Inhibitory Synapses in the Central Nervous System of the Cat , 1965, Nature.

[2]  W. Levick,et al.  Sustained and transient neurones in the cat's retina and lateral geniculate nucleus , 1971, The Journal of physiology.

[3]  W. Levick,et al.  Properties of rarely encountered types of ganglion cells in the cat's retina and on overall classification , 1974, The Journal of physiology.

[4]  I. W. Mclean,et al.  PERIODATE-LYSINE-PARAFORMALDEHYDE FIXATIVE A NEW FIXATIVE FOR IMMUNOELECTRON MICROSCOPY , 1974, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[5]  W. Levick,et al.  Brisk and sluggish concentrically organized ganglion cells in the cat's retina , 1974, The Journal of physiology.

[6]  J. Vanderhaeghen,et al.  New peptide in the vertebrate CNS reacting with antigastrin antibodies , 1975, Nature.

[7]  G. Dockray,et al.  Immunochemical evidence of cholecystokinin-like peptides in brain , 1976, Nature.

[8]  M. Runswick,et al.  Isolation, structure and biological activity of two cholecystokinin octapeptides from sheep brain , 1978, Nature.

[9]  J. Phillis,et al.  Actions of various gastrointestinal peptides on the isolated amphibian spinal cord. , 1979, Canadian journal of physiology and pharmacology.

[10]  R. Innis,et al.  Cholecystokinin receptor binding in brain and pancreas: Regulation of pancreatic bindign by cyclic and acyclic guanine nucleotides , 1980 .

[11]  J. Rehfeld,et al.  Cholecystokinin octapeptide: vesicular localization and calcium dependent release from rat brain in vitro. , 1980, Life sciences.

[12]  R. Jensen,et al.  Interaction of cholecystokinin with specific membrane receptors on pancreatic acinar cells. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[13]  G. Dockray.  Cholecystokinins in rat cerebral cortex: Identification, purification and characterization by immunochemical methods , 1980, Brain Research.

[14]  J. Rehfeld,et al.  Concentration and In Vivo Synthesis of Cholecystokinin in Subcortical Regions of the Rat Brain , 1980, Journal of Neurochemistry.

[15]  M. Randić,et al.  Cholecystokinin octapeptide excites dorsal horn neurons both in vivo and in vitro , 1981, Brain Research.

[16]  N. Osborne,et al.  Localization of cholecystokinin immunoreactivity in amacrine cells of the retina , 1981, Neuroscience Letters.

[17]  J. Rehfeld,et al.  Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons , 1981, Neuroscience.

[18]  J. Kelly,et al.  The actions of cholecystokinin and related peptides on pyramidal neurones of the mammalian hippocampus , 1981, Brain Research.

[19]  E. Eriksen,et al.  Neuropeptides in the retina: Evidence for differential topographical localization , 1981, Peptides.

[20]  S. Basinger,et al.  Cholecystokinin-like immunoreactivity in frog retina: Localization, characterization, and biosynthesis , 1981, Peptides.

[21]  G. Dockray,et al.  Development of region-specific antisera for the C-terminal tetrapeptide of gastrin/cholecystokinin and their use in studies of immunoreactive forms of cholecystokinin in rat brain , 1981, Neurochemistry International.

[22]  N. Osborne,et al.  Cholecystokinin and substance P immunoreactivity in retinas of rats, frogs, lizards and chicks. , 1982, Experimental eye research.

[23]  H. Wässle,et al.  Response latency of brisk‐sustained (X) and brisk‐transient (Y) cells in the cat retina , 1982, The Journal of physiology.

[24]  E. Jones,et al.  Cholecystokinin-immunoreactive neurons in rat and monkey cerebral cortex make symmetric synapses and have intimate associations with blood vessels. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[25]  U. Dräger,et al.  Neurofilaments contain alpha-melanocyte-stimulating hormone (alpha-MSH)-like immunoreactivity. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[26]  A. Peters,et al.  Cholecystokinin-like immunoreactive neurons in rat cerebral cortex , 1983, Neuroscience.

[27]  P. Thier,et al.  Action of iontophoretically applied dopamine on cat retinal ganglion cells , 1984, Brain Research.

[28]  H. Wässle,et al.  Pharmacological modulation of on and off ganglion cells in the cat retina , 1984, Neuroscience.

[29]  W. R. Levick,et al.  Another tungsten microelectrode , 1972, Medical and biological engineering.