Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor.

[1]  Zhiqian Guo,et al.  Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers. , 2005, Bioorganic & medicinal chemistry letters.

[2]  Zhiqian Guo,et al.  A convenient one-pot synthesis of asymmetric 1,3,5-triazine-2,4,6-triones and its application towards a novel class of gonadotropin-releasing hormone receptor antagonists. , 2005, Bioorganic & medicinal chemistry letters.

[3]  N. Ling,et al.  3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization. , 2005, Journal of medicinal chemistry.

[4]  Adam J Pawson,et al.  Gonadotropin-releasing hormone receptors. , 2004, Endocrine reviews.

[5]  Chen Chen,et al.  Nonpeptide Gonadotropin Releasing Hormone Antagonists , 2004 .

[6]  C. K. Chu,et al.  Practical synthesis of D- and l-2-cyclopentenone and their utility for the synthesis of carbocyclic antiviral nucleosides against orthopox viruses (smallpox, monkeypox, and cowpox virus). , 2003, The Journal of organic chemistry.

[7]  N. Soni,et al.  Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents. , 2003, Bioorganic & medicinal chemistry letters.

[8]  Sambasivarao Kotha,et al.  Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis , 2002 .

[9]  E. Negishi.  Handbook of organopalladium chemistry for organic synthesis , 2002 .

[10]  R. Kühne,et al.  Residues within transmembrane helices 2 and 5 of the human gonadotropin-releasing hormone receptor contribute to agonist and antagonist binding. , 2000, Molecular endocrinology.

[11]  S. Lindell,et al.  Synthesis of C-ribosyl imidazo[2,1-f][1,2,4]triazines as inhibitors of adenosine and AMP deaminases , 1999 .

[12]  S. Stanforth,et al.  Catalytic cross-coupling reactions in biaryl synthesis , 1998 .

[13]  D. Nelson,et al.  Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus. , 1996, Journal of medicinal chemistry.

[14]  D. Hughes,et al.  PROGRESS IN THE MITSUNOBU REACTION. A REVIEW , 1996 .

[15]  A. Haemers,et al.  Synthesis, reactions and biological evaluation of some 1,2,4-triazine derivatives , 1988 .

[16]  C. Tzeng,et al.  Synthesis of certain 5,6-diamino-as-triazines: precursors for fused heterocyclic systems , 1983 .