Failure of thermoregulation in the cold during hypoglycaemia induced by exercise and ethanol

1. After young men had exercised for approximately 2 hr at 70% maximum O2 uptake, and taken 28 ml. ethanol by mouth, their mean blood glucose fell to 2·17 m M. It fell further to 1·77 m M during a 30 min exposure to air at 14·5° C. Plasma lactate, glycerol, β‐hydroxybutyrate and free fatty acid concentrations increased.

[1]  L. H. Kedes,et al.  HYPOTHERMIA. A CLUE TO HYPOGLYCEMIA. , 1964, The New England journal of medicine.

[2]  K. Itaya,et al.  COLORIMETRIC DETERMINATION OF FREE FATTY ACIDS IN BIOLOGICAL FLUIDS. , 1965, Journal of lipid research.

[3]  W. Keatinge,et al.  Effect of food, alcohol, and hyoscine on body-temperature and reflex responses of men immersed in cold water. , 1960, Lancet.

[4]  H. Krebs,et al.  Enzymic determination of d(−)-β-hydroxybutyric acid and acetoacetic acid in blood , 1962 .

[5]  M. Allwood,et al.  The effect of insulin hypoglycaemia on blood flow in intact and sympathectomized extremities in man , 1957, The Journal of physiology.

[6]  A. Keys,et al.  The Evaluation of Leanness-Fatness in Man: Norms and Interrelationships , 1951, British Journal of Nutrition.

[7]  N. Freinkel,et al.  Alcohol hypoglycemia. VII. Further studies on the refractoriness of obese subjects. , 1968, Metabolism: clinical and experimental.

[8]  W R Keatinge,et al.  Elevation in set point for body temperature regulation after prolonged exercise , 1973, The Journal of physiology.

[9]  H. Krebs,et al.  Inhibition of hepatic gluconeogenesis by ethanol. , 1969, The Biochemical journal.

[10]  G. Cahill,et al.  Metabolic interactions of glucose, lactate, and beta-hydroxybutyrate in rat brain slices. , 1969, The American journal of physiology.

[11]  W. H. Hammond,et al.  Measurement and Interpretation of Subcutaneous fat, with Norms for Children and Young Adult Males , 1955, British journal of preventive & social medicine.

[12]  S. Weinhouse,et al.  Oxidation of endogenous fatty acids of rat tissues in vitro. , 1952, The Journal of biological chemistry.

[13]  N. Freinkel,et al.  ALCOHOL HYPOGLYCEMIA. I. CARBOHYDRATE METABOLISM OF PATIENTS WITH CLINICAL ALCOHOL HYPOGLYCEMIA AND THE EXPERIMENTAL REPRODUCTION OF THE SYNDROME WITH PURE ETHANOL. , 1963, The Journal of clinical investigation.

[14]  Roth.  Influence of massive doses of insulin on peripheral blood flow in man , 1940 .

[15]  S. A. Levine,et al.  SOME CHANGES IN THE CHEMICAL CONSTITUENTS OF THE BLOOD FOLLOWING A MARATHON RACE: WITH SPECIAL REFERENCE TO THE DEVELOPMENT OF HYPOGLYCEMIA , 1924 .

[16]  P. Vignais,et al.  ACTIVATION AND OXIDATION OF LONG CHAIN FATTY ACIDS BY RAT BRAIN * , 1958, Journal of Neurochemistry.

[17]  P. Strang.  Death due to exposure to cold in the New Zealand mountains. , 1969, The New Zealand medical journal.

[18]  H. Hohorst.  l-(+)-Lactate: Determination with Lactic Dehydrogenase and DPN , 1965 .

[19]  Observations on Olympic Athletes , 1929 .

[20]  S. Dworkin,et al.  INSULIN AND THE MECHANISM OF HIBERNATION , 1925 .

[21]  G F Cahill,et al.  Brain metabolism during fasting. , 1967, The Journal of clinical investigation.

[22]  K. Andersen,et al.  COMBINED EFFECT OF COLD AND ALCOHOL ON HEAT BALANCE IN MAN. , 1963, Journal of applied physiology.