Clinical use of carotid intima-media thickness: review of the literature.

Carotid intima-media thickness (CIMT) is a simple and inexpensive tool to assess the cumulative effect of atherosclerotic risk factors and is an independent predictor of future cardiovascular risk. CIMT is commonly used as a surrogate end point in research trials as a marker of atherosclerosis. However, new software programs have made CIMT a clinically practical examination for risk evaluation. CIMT correlates with cardiac risk factors and is an independent predictor of future myocardial infarction and stroke risk. Tests for subclinical atherosclerosis, such as CIMT, will help clinicians to more effectively identify the vulnerable patient who would benefit from aggressive prevention intervention.

[1]  M. Bots,et al.  Homocysteine and carotid intima-media thickness: a critical appraisal of the evidence. , 2004, Atherosclerosis.

[2]  Allen J. Taylor,et al.  Executive summary—can atherosclerosis imaging techniques improve the detection of patients at risk for ischemic heart disease? , 2003 .

[3]  Eric Vicaut,et al.  Carotid Intima-Media Thickness, Plaques, and Framingham Risk Score as Independent Determinants of Stroke Risk , 2005, Stroke.

[4]  Allen J. Taylor,et al.  ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: A Randomized Trial Comparing the Effects of Atorvastatin and Pravastatin on Carotid Intima Medial Thickness , 2002, Circulation.

[5]  J. Dwyer,et al.  Leisure time physical activity and early atherosclerosis: the Los Angeles Atherosclerosis Study. , 2003, The American journal of medicine.

[6]  P. Greenland,et al.  Clinical practice. Selecting asymptomatic patients for coronary computed tomography or electrocardiographic exercise testing. , 2003, The New England journal of medicine.

[7]  Nikolaus Marx,et al.  Improvement of cardiovascular risk markers by pioglitazone is independent from glycemic control: results from the pioneer study. , 2005, Journal of the American College of Cardiology.

[8]  M. Szklo,et al.  The relationship of active and passive smoking to carotid atherosclerosis 12-14 years later. , 1995, Preventive medicine.

[9]  Michael E. Miller,et al.  Effect of Amlodipine on the Progression of Atherosclerosis and the Occurrence of Clinical Events , 2000, Circulation.

[10]  J. David Spence,et al.  Carotid Plaque Area: A Tool for Targeting and Evaluating Vascular Preventive Therapy , 2002, Stroke.

[11]  J F Cornhill,et al.  Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. , 1999, JAMA.

[12]  R. Kronmal,et al.  Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. , 1999, The New England journal of medicine.

[13]  E. Lyden,et al.  Carotid intima media thickness decreases after pancreas transplantation. , 2002, Transplantation.

[14]  A. Zanchetti,et al.  The Verapamil in Hypertension and Atherosclerosis Study (VHAS): Results of long‐term randomized treatment with either verapamil or chlorthalidone on carotid intima‐media thickness , 1998, Journal of hypertension.

[15]  Arno W. Hoes,et al.  Common carotid intima-media thickness and risk of stroke and myocardial infarction: the Rotterdam Study. , 1997, Circulation.

[16]  V. Fuster.  Hurst's the Heart , 1966 .

[17]  A. Simon,et al.  Differential associations of statin and fibrate treatment with carotid arterial remodeling. , 2005, American journal of hypertension.

[18]  G. Berglund,et al.  Low-Dose Metoprolol CR/XL and Fluvastatin Slow Progression of Carotid Intima-Media Thickness: Main Results From the &bgr;-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS) , 2001, Circulation.

[19]  K. Karason,et al.  Weight loss and progression of early atherosclerosis in the carotid artery: a four-year controlled study of obese subjects , 1999, International Journal of Obesity.

[20]  D. O'leary,et al.  Intensive diabetes therapy and carotid intima-media thickness in type 1 diabetes mellitus. , 2003, The New England journal of medicine.

[21]  J. Lima,et al.  34th Bethesda Conference: Task force #3--What is the spectrum of current and emerging techniques for the noninvasive measurement of atherosclerosis? , 2003, Journal of the American College of Cardiology.

[22]  R. Ross.  Atherosclerosis is an inflammatory disease , 1999 .

[23]  A. Hofman,et al.  Predictive Value of Noninvasive Measures of Atherosclerosis for Incident Myocardial Infarction: The Rotterdam Study , 2004, Circulation.

[24]  Lewis H Kuller,et al.  A dietary and exercise intervention slows menopause-associated progression of subclinical atherosclerosis as measured by intima-media thickness of the carotid arteries. , 2004, Journal of the American College of Cardiology.

[25]  E. Vicaut,et al.  Correlation between the Framingham risk score and intima media thickness: the Paroi Artérielle et Risque Cardio-vasculaire (PARC) study. , 2007, Atherosclerosis.

[26]  P. Savage,et al.  Duration of diabetes and carotid wall thickness. The Insulin Resistance Atherosclerosis Study (IRAS). , 1997, Stroke.

[27]  T. Lakka,et al.  Blood pressure and the progression of carotid atherosclerosis in middle-aged men. , 1999, Hypertension.

[28]  W. Tracz,et al.  Association of increased carotid intima-media thickness with the extent of coronary artery disease , 2004, Heart.

[29]  M. Trip,et al.  Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolemia (ASAP): a prospective, randomised, double-blind trial , 2001, The Lancet.

[30]  K. Taylor,et al.  A Genome-Wide Scan for Carotid Artery Intima-Media Thickness: The Mexican-American Coronary Artery Disease Family Study , 2005, Stroke.

[31]  R H Selzer,et al.  The Role of Carotid Arterial Intima-Media Thickness in Predicting Clinical Coronary Events , 1998, Annals of Internal Medicine.

[32]  A. Smit,et al.  Effects of amlodipine and lisinopril on intima–media thickness in previously untreated, elderly hypertensive patients (the ELVERA trial) , 2004, Journal of hypertension.

[33]  P Pignoli,et al.  Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. , 1986, Circulation.

[34]  S P Azen,et al.  Influence of lifestyle modification on atherosclerotic progression determined by ultrasonographic change in the common carotid intima-media thickness. , 1997, The American journal of clinical nutrition.

[35]  J. Stein,et al.  Use of carotid intima-media thickness and vascular age to modify cardiovascular risk prediction. , 2006, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[36]  Y. Tamura,et al.  Strict glycemic control ameliorates the increase of carotid IMT in patients with type 2 diabetes. , 2006, Endocrine journal.

[37]  G. Franceschini,et al.  Clinical evaluation of probucol in hypercholesteremia: individual lipoprotein responses and inhibitory effect on carotid atherosclerosis progression. , 1997, Journal of cardiovascular pharmacology.

[38]  B. Fagerberg,et al.  Circulating oxidized LDL is associated with increased levels of cell-adhesion molecules in clinically healthy 58-year old men (AIR study). , 2002, Medical science monitor : international medical journal of experimental and clinical research.

[39]  M. Palta,et al.  Validation of a carotid intima-media thickness border detection program for use in an office setting. , 2006, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[40]  H. Büller,et al.  Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study , 2004, JAMA.

[41]  A. Kafetzakis,et al.  Association of subclinical wall changes of carotid, femoral, and popliteal arteries with obstructive coronary artery disease in patients undergoing coronary angiography. , 2005, Chest.

[42]  A. Nicolaides,et al.  Carotid and femoral ultrasound morphology screening and cardiovascular events in low risk subjects: a 10-year follow-up study (the CAFES-CAVE study) , 2001 .

[43]  A. Hofman,et al.  The association between coronary calcification assessed by electron beam computed tomography and measures of extracoronary atherosclerosis: the Rotterdam Coronary Calcification Study. , 2002, Journal of the American College of Cardiology.

[44]  G. Franceschini,et al.  Plasma lipoprotein(a) is an independent factor associated with carotid wall thickening in severely but not moderately hypercholesterolemic patients. , 1996, Stroke.

[45]  J. Salonen,et al.  Ultrasound B-mode imaging in observational studies of atherosclerotic progression. , 1993, Circulation.

[46]  H. White,et al.  Effects of Lowering Average or Below-Average Cholesterol Levels on the Progression of Carotid Atherosclerosis Results of the LIPID Atherosclerosis Substudy , 1998 .

[47]  P. Moulin,et al.  Incremental predictive value of carotid ultrasonography in the assessment of coronary risk in a cohort of asymptomatic type 2 diabetic subjects. , 2005, Diabetes care.

[48]  Richard Kahn,et al.  The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes. , 2005, Diabetes care.

[49]  G. Gamble,et al.  Effects of lowering average of below-average cholesterol levels on the progression of carotid atherosclerosis: results of the LIPID Atherosclerosis Substudy. LIPID Trial Research Group. , 1998, Circulation.

[50]  J. Salonen,et al.  Progression of carotid atherosclerosis and its determinants: a population-based ultrasonography study. , 1990, Atherosclerosis.

[51]  B. Fagerberg,et al.  Oxidized low‐density lipoprotein in plasma is a prognostic marker of subclinical atherosclerosis development in clinically healthy men , 2004, Journal of internal medicine.

[52]  J. McNeil,et al.  Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial. , 2006, Journal of the American College of Cardiology.

[53]  V. Fuster,et al.  Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. , 2000, Circulation.

[54]  C. Furberg,et al.  Results of the primary outcome measure and clinical events from the Asymptomatic Carotid Artery Progression Study. , 1995, The American journal of cardiology.

[55]  M. Bond,et al.  Increased subclinical atherosclerosis in young adults with metabolic syndrome: the Bogalusa Heart Study. , 2004, Journal of the American College of Cardiology.

[56]  A. Folsom,et al.  Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987-1993. , 1997, American journal of epidemiology.

[57]  J. Viikari,et al.  Interrelations Between Brachial Endothelial Function and Carotid Intima-Media Thickness in Young Adults: The Cardiovascular Risk in Young Finns Study , 2004, Circulation.

[58]  Stefan Störk,et al.  Carotid Artery Plaque Burden, Stiffness, and Mortality Risk in Elderly Men: A Prospective, Population-Based Cohort Study , 2004, Circulation.

[59]  Akihiro Inazu,et al.  Clinical efficacy of fluvastatin in the long-term treatment of familial hypercholesterolemia. , 1995, The American journal of cardiology.

[60]  H. Markus,et al.  Effect of rosiglitazone on common carotid intima-media thickness progression in coronary artery disease patients without diabetes mellitus. , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[61]  P. McBride,et al.  Ultrasound-detected carotid plaque as a predictor of cardiovascular events , 2006, Vascular medicine.

[62]  J. LeLorier,et al.  Intensive versus moderate lipid lowering with statins after acute coronary syndromes. , 2004, The New England journal of medicine.

[63]  J. Stein,et al.  Ultrasound-detected carotid plaque as a screening tool for advanced subclinical atherosclerosis. , 2005, American heart journal.

[64]  E. Jeffrey Metter,et al.  Metabolic syndrome amplifies the age-associated increases in vascular thickness and stiffness , 2004 .

[65]  J. Salonen,et al.  Ultrasonographically assessed carotid morphology and the risk of coronary heart disease. , 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

[66]  J D Dawson,et al.  Increased carotid intimal-medial thickness and coronary calcification are related in young and middle-aged adults. The Muscatine study. , 1999, Circulation.

[67]  S. Yusuf,et al.  Effects of Ramipril and Vitamin E on Atherosclerosis: The Study to Evaluate Carotid Ultrasound Changes in Patients Treated With Ramipril and Vitamin E (SECURE) , 2001, Circulation.

[68]  J. Dwyer,et al.  Dietary fiber and progression of atherosclerosis: the Los Angeles Atherosclerosis Study. , 2003, The American journal of clinical nutrition.