Fabrication of Dendrimer-like PAMAM Based on Silica Nanoparticles†

A G 4.0 dendrimer-like poly(amido amine) (PAMAM) based on silica nanoparticles was fabricated via a divergent approach. It was built from γ-aminopropyl silica nanoparticles (APSN) core via repetitive addition of acrylate (MA) and hexylenediamine (HDA). FT-IR and EA were used to monitor the progress of dendrimer during each step. The amino group content of the resulting product increased from 0.49 to 3.72 mmol/g after the 4th generation. In addition, the percentage of grafting increased with increasing generation and reached to 65.9% after 4th generation. It was found that the resulting silica nanoparticles could be dispersed in methanol with a mean hydrodynamic particle diameter of 152.7 nm although the silica nanoparticles had agglomerated during the storage period.

[1]  R. Haag,et al.  Dendritic polymers in biomedical applications: from potential to clinical use in diagnostics and therapy. , 2002, Angewandte Chemie.

[2]  J. Fréchet,et al.  Convergent dendrons and dendrimers: from synthesis to applications. , 2001, Chemical reviews.

[3]  D. Astruc,et al.  Dendritic catalysts and dendrimers in catalysis. , 2001, Chemical reviews.

[4]  Joost N. H. Reek,et al.  Übergangsmetallkatalyse mit funktionalisierten Dendrimeren , 2001 .

[5]  R. Haag.  Dendrimers and hyperbranched polymers as high-loading supports for organic synthesis. , 2001, Chemistry.

[6]  G. Newkome,et al.  Suprasupermolecules with Novel Properties: Metallodendrimers. , 1999, Chemical reviews.

[7]  Anthony E. Beezer,et al.  The synthesis of water soluble dendrimers, and their application as possible drug delivery systems , 1999 .

[8]  A. Cooper,et al.  Extraction of a hydrophilic compound from water into liquid CO2 using dendritic surfactants , 1997, Nature.

[9]  Steven C. Zimmerman,et al.  Dendrimers in Supramolecular Chemistry: From Molecular Recognition to Self-Assembly. , 1997, Chemical reviews.

[10]  M. Reetz,et al.  Systhesis and Catalytic Activity of Dendritic Diphosphane Metal Complexes , 1997 .

[11]  V. Tsukruk,et al.  Self-Assembled Multilayer Films from Dendrimers , 1997 .

[12]  Mona C. Wells,et al.  Interactions between Organized, Surface-Confined Monolayers and Vapor-Phase Probe Molecules. 10. Preparation and Properties of Chemically Sensitive Dendrimer Surfaces , 1996 .

[13]  S. Regen,et al.  Dendrimers as Building Blocks for Multilayer Construction , 1994 .

[14]  Lei Liu,et al.  Self-Assembly Motif for Creating Submicron Periodic Materials. Polymerized Crystalline Colloidal Arrays , 1994 .

[15]  W. Ford,et al.  Composite of Colloidal Crystals of Silica in Poly(methyl methacrylate) , 1994 .

[16]  G. Sukhorukov,et al.  Assembly of thin films by means of successive deposition of alternate layers of DNA and poly(allylamine) , 1993 .

[17]  Jean M. J. Fréchet,et al.  Light-harvesting dendrimers , 2000 .

[18]  W. Cao,et al.  Fabrication of a covalently attached self-assembly multilayer film via H-bonding attraction and subsequent UV-irradiation , 1999 .