Expansion and redifferentiation of adult human pancreatic islet cells.

[1]  A. Nolan,et al.  Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. , 2005, Biochemical and biophysical research communications.

[2]  O. Madsen,et al.  EGF-induced proliferation of adult human pancreatic duct cells is mediated by the MEK/ERK cascade , 2005, Laboratory Investigation.

[3]  B. Raaka,et al.  Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells , 2004, Science.

[4]  M. Mori,et al.  Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF. , 2004, Endocrinology.

[5]  D. Kooy,et al.  Clonal identification of multipotent precursors from adult mouse pancreas that generate neural and pancreatic lineages , 2004, Nature Biotechnology.

[6]  Douglas A. Melton,et al.  Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation , 2004, Nature.

[7]  M. Seno,et al.  Betacellulin improves glucose metabolism by promoting conversion of intraislet precursor cells to beta-cells in streptozotocin-treated mice. , 2003, American journal of physiology. Endocrinology and metabolism.

[8]  O. Korsgren,et al.  Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture. , 2003, Diabetes.

[9]  M. Fujimiya,et al.  NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice , 2003, Nature Medicine.

[10]  Ana D. Lopez,et al.  A novel approach to increase human islet cell mass while preserving beta-cell function. , 2002, Diabetes.

[11]  J. Habener,et al.  Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. , 2002, Endocrinology.

[12]  T. Miyatsuka,et al.  PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. , 2002, Diabetes.

[13]  M. Seno,et al.  Promotion of β-Cell Regeneration by Betacellulin in Ninety Percent-Pancreatectomized Rats. , 2001, Endocrinology.

[14]  S. Efrat,et al.  Inducible and reversible beta-cell autoimmunity and hyperplasia in transgenic mice expressing a conditional oncogene. , 2001, Diabetes.

[15]  Y. Matsuzawa,et al.  Recombinant human betacellulin promotes the neogenesis of beta-cells and ameliorates glucose intolerance in mice with diabetes induced by selective alloxan perfusion. , 2000, Diabetes.

[16]  Ana D. Lopez,et al.  A role for activin A and betacellulin in human fetal pancreatic cell differentiation and growth. , 2000, The Journal of clinical endocrinology and metabolism.

[17]  E. Ryan,et al.  Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. , 2000, The New England journal of medicine.

[18]  S. Bonner-Weir,et al.  In vitro cultivation of human islets from expanded ductal tissue. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[19]  F. Levine,et al.  Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro. , 2000, The Journal of endocrinology.

[20]  D. Schatz,et al.  Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells , 2000, Nature Medicine.

[21]  M. Zabel,et al.  Polyhormonal aspect of the endocrine cells of the human fetal pancreas , 1999, Histochemistry and Cell Biology.

[22]  G. Korbutt,et al.  Intraductal Collagenase Delivery into the Human Pancreas Using Syringe Loading or Controlled Perfusion , 1999, Transplantation proceedings.

[23]  L. Rossetti,et al.  Functional analysis of a conditionally transformed pancreatic beta-cell line. , 1998, Diabetes.

[24]  B. Hering,et al.  Assessment of intracellular insulin content during all steps of human islet isolation procedure. , 1998, Cell transplantation.

[25]  L. Orci,et al.  Two transgenic approaches to define the cell lineages in endocrine pancreas development , 1998, Molecular and Cellular Endocrinology.

[26]  T. Otonkoski,et al.  Growth Factor-Mediated Proliferation and Differentiation of Insulin-Producing INS-1 and RINm5F Cells: Identification of Betacellulin as a Novel β-Cell Mitogen. , 1998, Endocrinology.

[27]  Y. Matsuzawa,et al.  PDX-1 Induces Insulin and Glucokinase Gene Expressions in αTC1 Clone 6 Cells in the Presence of Betacellulin , 1996, Diabetes.

[28]  J. Rubin,et al.  Regulation of Proliferation and Differentiation of Human Fetal Pancreatic Islet Cells by Extracellular Matrix, Hepatocyte Growth Factor, and Cell-Cell Contact , 1996, Diabetes.

[29]  T. Hanafusa,et al.  Betacellulin and activin A coordinately convert amylase-secreting pancreatic AR42J cells into insulin-secreting cells. , 1996, The Journal of clinical investigation.

[30]  D. Hanahan,et al.  Betacellulin: a mitogen from pancreatic beta cell tumors. , 1993, Science.

[31]  R. James,et al.  Large-Scale Purification of Human Islets Utilizing Discontinuous Albumin Gradient on IBM 2991 Cell Separator , 1989, Diabetes.