C2,N-dimethylbenzylamine cyclopalladated compounds: evaluation of cytotoxic, mutagenic and antitubercular activities

[1]  I. Omae Applications of five-membered ring products of cyclometalation reactions as anticancer agents , 2014 .

[2]  F. Pavan,et al.  Synthesis and antimycobacterial activity of new pyrazolate-bridged dinuclear complexes of the type [Pd(mu-L)(N-3)(PPh3)](2) (PPh3 = triphenylphosphine; L = pyrazolates) , 2014 .

[3]  V. Rodríguez,et al.  Anticancer cyclometalated complexes of platinum group metals and gold , 2013 .

[4]  F. A. Resende,et al.  Antitumour and anti-inflammatory effects of palladium(II) complexes on Ehrlich tumour. , 2013, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[5]  M. D. Vargas,et al.  Novel 3-(aminomethyl)naphthoquinone mannich base-platinum(IV) complexes: synthesis, characterization, electrochemical and cytotoxic studies , 2013 .

[6]  H. Sadeghi-aliabadi,et al.  Dinuclear bridged biphosphinic and mononuclear cyclopalladated complexes of benzylamines: Synthesis, structural characterization and antitumor activity , 2013 .

[7]  Â. Pinto,et al.  Synthesis of novel isatin-type 5'-(4-Alkyl/Aryl-1H-1,2,3-triazoles) via 1,3-dipolar cycloaddition reactions , 2013 .

[8]  E. Tiekink,et al.  Anti‐cancer potential of selenium‐ and tellurium‐containing species: opportunities abound! , 2012 .

[9]  Regina H. A. Santos,et al.  Structure and antimycobacterial activity of the novel organometallic (Pd(C-bzan)(SCN)(dppp)) compound , 2012 .

[10]  A. Batista,et al.  Chemical mechanism of controlled nitric oxide release from trans-[RuCl([15]aneN4)NO](PF6)2 as a vasorelaxant agent , 2012, Transition Metal Chemistry.

[11]  F. Pavan,et al.  Binuclear cyclopalladated compounds with antitubercular activity: synthesis and characterization of [{Pd(C2,N-dmba)(X)}2(μ-bpp)] (X = Cl, Br, NCO, N3; bpp = 1,3-bis(4-pyridyl)propane) , 2012 .

[12]  P. Cardona Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance , 2012 .

[13]  F. Pavan,et al.  An Approach to the Search for New Drugs Against Tuberculosis , 2012 .

[14]  A. V. Netto,et al.  Thermal study of mononuclear Pd(II) complexes of the type [Pd(X)2(Rtu)(PPh3)] (X = Cl, SCN; Rtu = N-methylthiourea, N-phenylthiourea) , 2011 .

[15]  J. Gut,et al.  Synthesis and in vitro antimalarial and antitubercular activity of gold(III) complexes containing thiosemicarbazone ligands , 2011 .

[16]  E. S. Coimbra,et al.  Synthesis of 4-aminoquinoline analogues and their platinum(II) complexes as new antileishmanial and antitubercular agents. , 2011, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[17]  Regina H. A. Santos,et al.  Self-assembly of cyclometallated Pd(II) compounds directed by C–H⋅⋅⋅π interactions: A structural evidence for metalloaromaticity in a cyclopalladated ring , 2011 .

[18]  S. Smaili,et al.  A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells , 2011, BMC Cancer.

[19]  F. Pavan,et al.  Antimycobacterial and antitumor activities of palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N3)2(isn)(2)]. , 2010, European journal of medicinal chemistry.

[20]  Syed Zeeshan Haider,et al.  Synthesis, crystal structures and, antibacterial and antiproliferative activities in vitro of palladium(II) complexes of triphenylphosphine and thioamides , 2010 .

[21]  R. Frem,et al.  3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: synthesis, spectral studies and antitumor activity. , 2010, European journal of medicinal chemistry.

[22]  J. Ellena,et al.  Palladium(II) complexes with thiosemicarbazones: syntheses, characterization and cytotoxicity against breast cancer cells and Anti-Mycobacterium tuberculosis activity , 2010 .

[23]  H. Beraldo,et al.  Organotin(IV) complexes with 2-acetylpyridine benzoyl hydrazones: antimicrobial activity , 2010 .

[24]  P. Sadler,et al.  Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs. , 2009, Drug discovery today.

[25]  F. Pavan,et al.  Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba=N,N-dimethylbenzylamine, tu=thiourea). , 2009, European journal of medicinal chemistry.

[26]  G. Natile,et al.  Mechanistic insight into the cellular uptake and processing of cisplatin 30 years after its approval by FDA , 2009 .

[27]  C. Sirlin,et al.  A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP. , 2009, Cancer research.

[28]  A. Hazrati,et al.  Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity. , 2009, Dalton transactions.

[29]  A. Garoufis,et al.  Palladium coordination compounds as anti-viral, anti-fungal, anti-microbial and anti-tumor agents , 2009 .

[30]  C. Bincoletto,et al.  Pre-clinical antitumour evaluation of Biphosphinic Palladacycle Complex in human leukaemia cells. , 2009, Chemico-biological interactions.

[31]  V. Brabec,et al.  Cytotoxicity, mutagenicity, cellular uptake, DNA and glutathione interactions of lipophilic trans-platinum complexes tethered to 1-adamantylamine. , 2008, Journal of inorganic biochemistry.

[32]  P. Sadler,et al.  New trends for metal complexes with anticancer activity. , 2008, Current opinion in chemical biology.

[33]  M. Bergomi,et al.  Studies on the anti-proliferative effects of novel DNA-intercalating bipyridyl-thiourea-Pt(II) complexes against cisplatin-sensitive and -resistant human ovarian cancer cells. , 2008, Journal of inorganic biochemistry.

[34]  M. Jakupec,et al.  Antitumour metal compounds: more than theme and variations. , 2008, Dalton transactions.

[35]  S. Fricker Metal based drugs: from serendipity to design. , 2007, Dalton transactions.

[36]  A. Caires Recent advances involving palladium (II) complexes for the cancer therapy. , 2007, Anti-cancer agents in medicinal chemistry.

[37]  C. Sirlin,et al.  Synthesis of cycloruthenated compounds as potential anticancer agents , 2007 .

[38]  W. Vilegas,et al.  Assessment of DNA damage by extracts and fractions of Strychnos pseudoquina, a Brazilian medicinal plant with antiulcerogenic activity. , 2006, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[39]  Regina H. A. Santos,et al.  Supramolecular assemblies of cis-palladium complexes dominated by CH⋯Cl interactions , 2006 .

[40]  R. Frem,et al.  Low-weight coordination polymers derived from the self-assembly reactions of Pd(II) pyrazolyl compounds and azide ion , 2005 .

[41]  J. Dupont,et al.  The potential of palladacycles: more than just precatalysts. , 2005, Chemical reviews.

[42]  C. Bincoletto,et al.  Chiral cyclopalladated complexes derived from N,N-dimethyl-1-phenethylamine with bridging bis(diphenylphosphine)ferrocene ligand as inhibitors of the cathepsin B activity and as antitumoral agents. , 2005, Bioorganic & medicinal chemistry.

[43]  S. Berners‐Price,et al.  Mitochondrial permeability transition induced by dinuclear gold(I)-carbene complexes: potential new antimitochondrial antitumour agents. , 2004, Journal of inorganic biochemistry.

[44]  M. Kubiak,et al.  Synthesis, structural, physico-chemical and biological properties of new palladium(II) complexes with 2,6-dimethyl-4-nitropyridine. , 2004, Journal of inorganic biochemistry.

[45]  K. Prasad,et al.  The Art of Meeting Palladium Specifications in Active Pharmaceutical Ingredients Produced by Pd-Catalyzed Reactions , 2004 .

[46]  I. Omae Intramolecular five-membered ring compounds and their applications , 2004 .

[47]  S. Galli,et al.  Decreased mitochondrial nitric oxide synthase activity and hydrogen peroxide relate persistent tumoral proliferation to embryonic behavior. , 2003, Cancer research.

[48]  A. Isab,et al.  Multinuclear NMR ( 1 H, 13 C, 15 N and 107 Ag) studies of the silver cyanide complexes of thiourea and substituted thioureas , 2002 .

[49]  N. Farrell Biomedical uses and applications of inorganic chemistry. An overview , 2002 .

[50]  F. Portaels,et al.  Resazurin Microtiter Assay Plate: Simple and Inexpensive Method for Detection of Drug Resistance in Mycobacterium tuberculosis , 2002, Antimicrobial Agents and Chemotherapy.

[51]  Regina H. A. Santos,et al.  SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF DICHLOROBIS (1-PHENYL-3-METHYLPYRAZOLE) PALLADIUM(II) AND DIAZIDOBIS (1-PHENYL-3-METHYLPYRAZOLE) PALLADIUM(II) , 2001 .

[52]  Regina H. A. Santos,et al.  1,3-DIPOLAR CYCLOADDITION OF CS2 TO THE COORDINATED AZIDE IN THE CYCLOPALLADATED [Pd(bzan)(μ-N3)]2. CRYSTAL AND MOLECULAR STRUCTURE OF DI(μ-N,S-1,2,3,4-THIATRIAZOLE-5-THIOLATE)BIS[(BENZYLIDENEANILINE-C2,N)PALLADIUM(II)] , 2001 .

[53]  E. Zeiger,et al.  The Ames Salmonella/microsome mutagenicity assay. , 2000, Mutation research.

[54]  S. Lippard,et al.  Structure, Recognition, and Processing of Cisplatin-DNA Adducts. , 1999, Chemical reviews.

[55]  A. Caires,et al.  Síntese e atividade citotóxica de alguns azido-ciclopaladados estabilizados com ligantes bifosfínicos , 1999 .

[56]  Regina H. A. Santos,et al.  CYCLOADDITION REACTION OF THE AZIDO-BRIDGED CYCLOMETALLATED COMPLEX [Pd(dmba)N3]2 WITH CS2. CRYSTAL AND MOLECULAR STRUCTURE OF DI(μ, N,S-l,2,3,4-THIATRIAZOLE-5-THIOLATE)BIS[(N,N-DIMETHYLBENZYL-AMINE-C2,N)PALLADIUM(II)] , 1999 .

[57]  A. Caires,et al.  Synthesis, characterization and thermal behavior of cyclopalladated compounds of the type [Pd{C6H4CH2N(CH3)2}(μ-X)]2 (X=Cl, nco, SCN, CN) , 1998 .

[58]  J. Perez,et al.  Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA. , 1998, Journal of medicinal chemistry.

[59]  C. Alonso,et al.  Palladium(II) 4,5-diphenylimidazole cyclometalated complexes : DNA interaction , 1997 .

[60]  L. Collins,et al.  Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium , 1997, Antimicrobial agents and chemotherapy.

[61]  J. Bünger,et al.  Cyto- and genotoxic effects of coordination complexes of platinum, palladium and rhodium in vitro , 1996, International archives of occupational and environmental health.

[62]  M. Tilby,et al.  Effect of quercetin on the genotoxic potential of cisplatin , 1996, International journal of cancer.

[63]  G. M. Kazankov,et al.  Kinetics and mechanism of halogen-bridge cleavage in dimethylaminomethylphenyl-C1,N pallada- and platina-cycles by pyridines. pressure effects, and crystal structures of the N,N-cis reaction product, its N,N-trans orthometallated analogue and a dimer of similar reactivity , 1995 .

[64]  G. Socrates,et al.  Infrared characteristic group frequencies : tables and charts , 1994 .

[65]  A. Ryabov Mechanisms of intramolecular activation of carbon-hydrogen bonds in transition-metal complexes , 1990 .

[66]  M. Pfeffer,et al.  Reaction of cyclopalladated compounds. 15. Controlled synthesis of heterocyclic compounds through ring enlargement by alkyne insertions into the palladium-carbon bonds of cyclopalladated amines followed by ring closure , 1987 .

[67]  Alexander D. Ryabov,et al.  Kinetics and mechanism of ortho-palladation of ring-substituted NN-dimethylbenzylamines , 1985 .

[68]  T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. , 1983, Journal of immunological methods.

[69]  B. Ames,et al.  Revised methods for the Salmonella mutagenicity test. , 1983, Mutation research.

[70]  G. Socrates,et al.  Infrared Characteristic Group Frequencies , 1980 .

[71]  T. Boschi,et al.  Far-infrared study of palladium(II)–halogen complexes with chelating ligands containing nitrogen and σ carbon as donor atoms , 1970 .

[72]  A. C. Cope,et al.  Electrophilic aromatttic substitution reactions by platinum(II) and palladium(II) chlorides on N,N-dimethylbenzylamines , 1968 .

[73]  H. Irving,et al.  Infra-red absorption spectra of complexes of thiourea , 1964 .

[74]  T. J. Lane,et al.  Infrared Absorption Spectra of Inorganic Coördination Complexes. XIV. Infrared Studies of Some Metal Thiourea Complexes1a , 1958 .