Investigation of topical intranasal cocaine for sinonasal procedures: a randomized, phase III clinical trial

The objective of this trial was to demonstrate the clinical efficacy and safety of topical cocaine as part of the effort to gain regulatory approval from the United States Food and Drug Administration.

[1]  Tom Shokri,et al.  Systemic Pharmacokinetics of Topical Intranasal Cocaine in Healthy Subjects , 2019, American journal of rhinology & allergy.

[2]  D. Butzbach,et al.  Is atomised intranasal cocaine systemically absorbed during endoscopic sinus surgery? , 2019, Rhinology.

[3]  A. Farboud,et al.  Assessing the safety and efficacy of drugs used in preparing the nose for diagnostic and therapeutic procedures: a systematic review , 2016, Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery.

[4]  B. Rotenberg,et al.  Is cocaine a safe topical agent for use during endoscopic sinus surgery? , 2016, The Laryngoscope.

[5]  A. Psaltis,et al.  Hemostasis in sinus surgery , 2016, Current opinion in otolaryngology & head and neck surgery.

[6]  M. Tewfik,et al.  Topical cocaine vs adrenaline in endoscopic sinus surgery: a blinded randomized controlled study , 2014, International forum of allergy & rhinology.

[7]  Asbjørn Mohr Drewes,et al.  Human Experimental Pain Models for Assessing the Therapeutic Efficacy of Analgesic Drugs , 2012, Pharmacological Reviews.

[8]  H. Stammberger,et al.  Systematic review of topical vasoconstrictors in endoscopic sinus surgery , 2011, The Laryngoscope.

[9]  Marilyn A Huestis,et al.  Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration. , 2006, Journal of analytical toxicology.

[10]  N. Jones,et al.  Cocaine: what role does it have in current ENT practice? A review of the current literature , 2006, The Journal of Laryngology & Otology.

[11]  C. Hartrick,et al.  The Numeric Rating Scale for Clinical Pain Measurement: A Ratio Measure? , 2003, Pain practice : the official journal of World Institute of Pain.

[12]  E. Cone,et al.  Elimination of cocaine and metabolites in plasma, saliva, and urine following repeated oral administration to human volunteers. , 2000, Journal of analytical toxicology.

[13]  B. S. Liao,et al.  A Preliminary Study of Cocaine Absorption From the Nasal Mucosa , 1999, The Laryngoscope.

[14]  M. Holtel,et al.  Absorption of Topical Cocaine in Rhinologic Procedures , 1996, The Laryngoscope.

[15]  B. J. Bailey.  Looking Back at a Century of Cocaine‐Use and Abuse , 1996, The Laryngoscope.

[16]  H. Wiedemann,et al.  Cardiac Complication From Use of Cocaine and Phenylephrine in Nasal Septoplasty , 1995 .

[17]  C. Sakai,et al.  First Place — Resident Clinical Science Award 1993: A Comparison of Cocaine vs. Lidocaine with Oxymetazoline for Use in Nasal Procedures , 1993, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[18]  R. Otto,et al.  Effect of Intranasal Cocaine on the Urine Drug Screen for Benzoylecgonine , 1992, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[19]  R. T. Jackson,et al.  Interaction of cocaine with nasal mucosa. , 1991, Archives of otolaryngology--head & neck surgery.

[20]  R. T. Jackson.  Mechanism of Action of Some Commonly Used Nasal Drugs , 1991, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[21]  E. E. Gresch.  Cocaine-Induced Coronary-Artery Vasoconstriction , 1990 .

[22]  C. Yancy,et al.  Cocaine-induced coronary-artery vasoconstriction. , 1989, The New England journal of medicine.

[23]  D. Fairbanks.  Cocaine: Friend or Foe? , 1989, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[24]  Y. Chiu,et al.  Myocardial infarction with topical cocaine anesthesia for nasal surgery. , 1986, Archives of otolaryngology--head & neck surgery.

[25]  M. Johns,et al.  Metabolism of Intranasally Applied Cocaine , 1977, The Annals of otology, rhinology, and laryngology.

[26]  Pamela Ramser,et al.  Cocaine , 1890, The Hospital.