Signaling Takes Shape in the Immune System

[1]  K A Arndt,et al.  Cutting edge , 2012, Archives of dermatology.

[2]  Thomas D. Pollard,et al.  Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex , 2000, The Journal of cell biology.

[3]  E. Bröcker,et al.  Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. , 2000, Immunity.

[4]  S. Bromley,et al.  A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[5]  M. Davis,et al.  Differential clustering of CD4 and CD3zeta during T cell recognition. , 2000, Science.

[6]  P. Roche,et al.  Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation , 2000, Nature Immunology.

[7]  L. Samelson,et al.  Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. , 2000, The Journal of biological chemistry.

[8]  Barbara Hausmann,et al.  A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity , 2000, Nature.

[9]  D. Cantrell,et al.  The Gtpase Rho Controls a P53-Dependent Survival Checkpoint during Thymopoiesis , 2000, The Journal of experimental medicine.

[10]  S. Bromley,et al.  Cutting Edge: Hierarchy of Chemokine Receptor and TCR Signals Regulating T Cell Migration and Proliferation1 , 2000, The Journal of Immunology.

[11]  Michael L. Dustin,et al.  The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling , 2000, Nature Immunology.

[12]  M. Aepfelbacher,et al.  The Polarization Defect of Wiskott-Aldrich Syndrome Macrophages Is Linked to Dislocalization of the Arp2/3 Complex1 , 2000, The Journal of Immunology.

[13]  D. Williams,et al.  Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. , 2000, Science.

[14]  Deborah A. Brown,et al.  Structure and Function of Sphingolipid- and Cholesterol-rich Membrane Rafts* , 2000, The Journal of Biological Chemistry.

[15]  L. Machesky.  Putting on the Brakes A Negative Regulatory Function for Ena/VASP Proteins in Cell Migration , 2000, Cell.

[16]  Karel Drbal,et al.  Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation , 2000, The Journal of experimental medicine.

[17]  Toshifumi Takao,et al.  Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases , 2000, Nature.

[18]  R. Steinman,et al.  Transport of peptide-MHC class II complexes in developing dendritic cells. , 2000, Science.

[19]  J. Wehland,et al.  Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton , 2000, The Journal of cell biology.

[20]  D. Olive,et al.  Tec kinases: a family with multiple roles in immunity. , 2000, Immunity.

[21]  E. Schaeffer,et al.  PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes , 2000, Nature.

[22]  M. Roth,et al.  Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3 , 2000, Current Biology.

[23]  R. Zaru,et al.  Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes , 2000, Current Biology.

[24]  J W Sedat,et al.  Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. , 2000, Science.

[25]  P. Más,et al.  A novel functional interaction between Vav and PKCtheta is required for TCR-induced T cell activation. , 2000, Immunity.

[26]  Y. Yashiro‐Ohtani,et al.  Non-CD28 Costimulatory Molecules Present in T Cell Rafts Induce T Cell Costimulation by Enhancing the Association of TCR with Rafts1 , 2000, The Journal of Immunology.

[27]  Michael Loran Dustin,et al.  Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition. , 2000, Seminars in immunology.

[28]  M. Yaffe,et al.  Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade* , 2000, The Journal of Biological Chemistry.

[29]  Elaine Fuchs,et al.  Directed Actin Polymerization Is the Driving Force for Epithelial Cell–Cell Adhesion , 2000, Cell.

[30]  Deborah A. Brown,et al.  Lipid-dependent Targeting of G Proteins into Rafts* , 2000, The Journal of Biological Chemistry.

[31]  Alan Aderem,et al.  Dynamic Interactions of Macrophages with T Cells during Antigen Presentation , 1999, The Journal of experimental medicine.

[32]  Giulio Superti-Furga,et al.  Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling , 1999, Nature.

[33]  P. W. Janes,et al.  Aggregation of Lipid Rafts Accompanies Signaling via the T Cell Antigen Receptor , 1999, The Journal of cell biology.

[34]  F. Sallusto,et al.  Two subsets of memory T lymphocytes with distinct homing potentials and effector functions , 1999, Nature.

[35]  E. Wolf,et al.  CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs , 1999, Cell.

[36]  Z Reich,et al.  Thermodynamics of T cell receptor binding to peptide-MHC: evidence for a general mechanism of molecular scanning. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[37]  M. Cahalan,et al.  Mapping the sensitivity of T cells with an optical trap: polarity and minimal number of receptors for Ca(2+) signaling. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[38]  S. Bromley,et al.  The immunological synapse: a molecular machine controlling T cell activation. , 1999, Science.

[39]  Takashi Saito,et al.  Dependence of T Cell Antigen Recognition on the Dimensions of an Accessory Receptor–Ligand Complex , 1999, The Journal of experimental medicine.

[40]  Gerhard Wagner,et al.  Structure of a Heterophilic Adhesion Complex between the Human CD2 and CD58 (LFA-3) Counterreceptors , 1999, Cell.

[41]  Timothy J. Mitchison,et al.  Spatial control of actin polymerization during neutrophil chemotaxis , 1999, Nature Cell Biology.

[42]  B. Baird,et al.  Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant Membranes , 1999, The Journal of cell biology.

[43]  M. Kirschner,et al.  The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly , 1999, Cell.

[44]  D. Nelson,et al.  Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein. , 1999, Journal of immunology.

[45]  M. Turner,et al.  The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-kappaB pathways. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. Ashwell,et al.  Cutting edge: the CD45 tyrosine phosphatase is an inhibitor of Lck activity in thymocytes. , 1999, Journal of immunology.

[47]  A. Lanzavecchia,et al.  T lymphocyte costimulation mediated by reorganization of membrane microdomains. , 1999, Science.

[48]  G. Koretzky,et al.  The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors , 1999, Current Biology.

[49]  M. Davis,et al.  A receptor/cytoskeletal movement triggered by costimulation during T cell activation. , 1998, Science.

[50]  C. McGlade,et al.  Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc , 1998, Oncogene.

[51]  A. Kupfer,et al.  TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site. , 1998, Journal of immunology.

[52]  B. Mayer,et al.  Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76. , 1998, Immunity.

[53]  T. Roach,et al.  The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages , 1998, Current Biology.

[54]  Patricia L. Widder,et al.  A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts , 1998, Cell.

[55]  Colin R. F. Monks,et al.  Three-dimensional segregation of supramolecular activation clusters in T cells , 1998, Nature.

[56]  L. Samelson,et al.  LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. , 1998, Immunity.

[57]  Philip R. Cohen,et al.  Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. , 1998, Immunity.

[58]  L. Tuosto,et al.  CD28 affects the earliest signaling events generated by TCR engagement , 1998, European journal of immunology.

[59]  G. Koretzky,et al.  Adaptor proteins in lymphocyte antigen-receptor signaling. , 1998, Current opinion in immunology.

[60]  M. Davis,et al.  Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[61]  F. Alt,et al.  Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction , 1998, Current Biology.

[62]  K. Tedford,et al.  Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor , 1998, Current Biology.

[63]  A. Weiss,et al.  Cytoskeletal Polarization of T Cells Is Regulated by an Immunoreceptor Tyrosine-based Activation Motif–dependent Mechanism , 1998, The Journal of cell biology.

[64]  J. Noel,et al.  Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. , 1998, Science.

[65]  Michael Loran Dustin,et al.  Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity* , 1997, The Journal of Biological Chemistry.

[66]  A. Cheng,et al.  Protein tyrosine kinases in thymocyte development. , 1997, Current opinion in immunology.

[67]  Z. Li,et al.  Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[68]  A. Khoruts,et al.  In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells , 1997, The Journal of experimental medicine.

[69]  Mark M. Davis,et al.  Ligand-specific oligomerization of T-cell receptor molecules , 1997, Nature.

[70]  C. Der,et al.  Lck regulates Vav activation of members of the Rho family of GTPases , 1997, Molecular and cellular biology.

[71]  C. Figdor,et al.  Dual role of the actin cytoskeleton in regulating cell adhesion mediated by the integrin lymphocyte function-associated molecule-1. , 1997, Molecular biology of the cell.

[72]  K. Schuebel,et al.  Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product , 1997, Nature.

[73]  W. Rodgers,et al.  Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains , 1996, The Journal of cell biology.

[74]  Robyn L. Stanfield,et al.  An αβ T Cell Receptor Structure at 2.5 Å and Its Orientation in the TCR-MHC Complex , 1996, Science.

[75]  Daniel Choquet,et al.  Ligand binding regulates the directed movement of β1 integrins on fibroblasts , 1996, Nature.

[76]  J. Szöllősi,et al.  Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY. , 1996, Journal of immunology.

[77]  J M Miller,et al.  Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes. , 1996, The Journal of clinical investigation.

[78]  L. Lim,et al.  A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures , 1996, Molecular and cellular biology.

[79]  A. Elson,et al.  Protein-tyrosine Phosphatase ϵ , 1995, The Journal of Biological Chemistry.

[80]  J. Cloutier,et al.  Requirement of the SH3 and SH2 domains for the inhibitory function of tyrosine protein kinase p50csk in T lymphocytes , 1995, Molecular and cellular biology.

[81]  J. Chant,et al.  Regulation of the polarization of T cells toward antigen-presenting cells by Ras-related GTPase CDC42. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[82]  A. Lanzavecchia,et al.  Serial triggering of many T-cell receptors by a few peptide–MHC complexes , 1995, Nature.

[83]  M. Davis,et al.  Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[84]  W. Paul,et al.  Lymphocyte responses and cytokines , 1994, Cell.

[85]  D A Lauffenburger,et al.  Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated , 1993, The Journal of cell biology.

[86]  J Ureña,et al.  SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange , 1993, Molecular and cellular biology.

[87]  R. Klausner,et al.  Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. , 1992, Science.

[88]  T. Mosmann,et al.  Polarized expression of cytokines in cell conjugates of helper T cells and splenic B cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[89]  Timothy A. Springer,et al.  Adhesion receptors of the immune system , 1990, Nature.

[90]  A. Kleinfeld,et al.  Short term exposure to cis unsaturated free fatty acids inhibits degranulation of cytotoxic T lymphocytes. , 1990, Journal of immunology.

[91]  Michael L. Dustin,et al.  T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1 , 1989, Nature.

[92]  R. Klausner,et al.  LIPID DOMAINS IN MEMBRANES * , 1982, Annals of the New York Academy of Sciences.

[93]  R. Klausner,et al.  Lipid domains in membranes. Evidence derived from structural perturbations induced by free fatty acids and lifetime heterogeneity analysis. , 1980, The Journal of biological chemistry.

[94]  E. Unanue,et al.  Two distinct mechanisms for redistribution of lymphocyte surface macromolecules. I. Relationship to cytoplasmic myosin , 1978, The Journal of cell biology.

[95]  E. Unanue,et al.  LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES , 1973, The Journal of experimental medicine.

[96]  E. Unanue,et al.  LIGAND-INDUCED MOVEMENT OF LYMPHOCYTE MEMBRANE MACROMOLECULES , 1972, The Journal of experimental medicine.

[97]  S. Bromley,et al.  The immunological synapse. , 2001, Annual review of immunology.

[98]  L. Frati,et al.  RAC1/P38 MAPK signaling pathway controls beta1 integrin-induced interleukin-8 production in human natural killer cells. , 2000, Immunity.

[99]  G. Koretzky,et al.  Adapter proteins in lymphocyte antigen-receptor signaling. , 2000, Current opinion in immunology.

[100]  X. Q. Chen,et al.  PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. , 1998, Molecular cell.

[101]  A. Lanzavecchia,et al.  The duration of antigenic stimulation determines the fate of naive and effector T cells. , 1998, Immunity.

[102]  E. Kaldjian,et al.  Orchestrated information transfer underlying leukocyte endothelial interactions. , 1996, Annual review of immunology.

[103]  Z. Y. Liu,et al.  Activation of mechanical responses in leukocytes. , 1990, Biorheology.

[104]  Y. Shoenfeld,et al.  [The T cell receptor]. , 1985, Harefuah.

[105]  M. Norcross,et al.  A synaptic basis for T-lymphocyte activation. , 1984, Annales d'immunologie.