Estimation and Design Criteria for Multiresponse Non‐Linear Models with Non‐Homogeneous Variance

(A fourth aspect, namely that of discriminating between rival models, including the choice of suitable discriminatory experiments, will not be considered here. The reader is referred to papers by Hill and Hunter (1966), Box and Hill (1967) and Box and Henson (1969).) Applications of previous work on these topics have been limited by the assumption of a constant variance-covariance structure; we show here how this assumption can be relaxed. Some simple numerical examples of non-constant response variance are the following: