Three-dimensional endoscopic optical coherence tomography by use of a two-axis microelectromechanical scanning mirror

We present a three-dimensional (3D) endoscopic optical coherence tomography (OCT) system based on a dual-axis scanning microelectromechanical system (MEMS) mirror. The diameter of the MEMS mirror was 1.2mm and both axes were capable of scanning greater than 20° with linearity. The endoscopic MEMS probe was integrated with an OCT system and volume images were obtained at a rate of 3frames∕s by means of two-axis lateral scanning combined with an axial scan. In the initial investigations, 3D OCT images of healthy rabbit trachea as well as images of normal and cancerous regions of hamster cheek pouch tissue were obtained.

[1]  S Yazdanfar,et al.  Electrostatic micromachine scanning mirror for optical coherence tomography. , 2003, Optics letters.

[2]  Guann-Pyng Li,et al.  Low-voltage polymer-based scanning cantilever for in vivo optical coherence tomography. , 2005, Optics letters.

[3]  G. Fedder,et al.  Endoscopic optical coherence tomography based on a microelectromechanical mirror. , 2001, Optics letters.

[4]  Zhongping Chen,et al.  Removal of a mirror image and enhancement of the signal-to-noise ratio in Fourier-domain optical coherence tomography using an electro-optic phase modulator. , 2005, Optics letters.

[5]  Wei Xu,et al.  Phase-resolved optical Doppler tomography for imaging flow dynamics in microfluidic channels , 2004 .

[6]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[7]  J. Fujimoto,et al.  High-speed phase- and group-delay scanning with a grating-based phase control delay line. , 1997, Optics letters.

[8]  V. Milanovic,et al.  Multilevel beam SOI-MEMS fabrication and applications , 2004 .

[9]  S. Yun,et al.  High-speed optical frequency-domain imaging. , 2003, Optics express.

[10]  J. Izatt,et al.  Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design. , 1999, Optics letters.

[11]  J. Fujimoto,et al.  In vivo endoscopic optical biopsy with optical coherence tomography. , 1997, Science.

[12]  D. McCormick,et al.  Gimbal-less monolithic silicon actuators for tip-tilt-piston micromirror applications , 2004, IEEE Journal of Selected Topics in Quantum Electronics.