Altered distribution of bone matrix proteins and defective bone mineralization in klotho-deficient mice.

[1]  M. Kuro-o,et al.  Protective Roles of DMP1 in High Phosphate Homeostasis , 2012, PloS one.

[2]  E. Farrow,et al.  Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. , 2011, Bone.

[3]  Kimimitsu Oda,et al.  Immunolocalization of DMP1 and sclerostin in the epiphyseal trabecule and diaphyseal cortical bone of osteoprotegerin deficient mice. , 2010, Biomedical research.

[4]  L. Bonewald,et al.  The Biological Function of DMP-1 in Osteocyte Maturation Is Mediated by Its 57-kDa C-terminal Fragment , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[5]  M. Kuro-o.  Overview of the FGF23-Klotho axis , 2010, Pediatric Nephrology.

[6]  R. Takagi,et al.  FGF23 is mainly synthesized by osteocytes in the regularly distributed osteocytic lacunar canalicular system established after physiological bone remodeling. , 2009, Journal of electron microscopy.

[7]  M. S. Razzaque.  The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis , 2009, Nature Reviews Endocrinology.

[8]  S. Fukumoto.  The role of bone in phosphate metabolism , 2009, Molecular and Cellular Endocrinology.

[9]  Kimimitsu Oda,et al.  Warfarin administration disrupts the assembly of mineralized nodules in the osteoid. , 2009, Journal of electron microscopy.

[10]  M. Razzaque,et al.  In vivo genetic evidence for klotho‐dependent, fibroblast growth factor 23 (Fgf23) ‐mediated regulation of systemic phosphate homeostasis , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[11]  N. Amizuka,et al.  Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency. , 2008, Histology and histopathology.

[12]  M. McKee,et al.  Matrix Gla Protein Inhibition of Tooth Mineralization , 2008, Journal of dental research.

[13]  Y. Nabeshima,et al.  α-Klotho: A Regulator That Integrates Calcium Homeostasis , 2007, American Journal of Nephrology.

[14]  Minqi Li,et al.  A histological assessment on the distribution of the osteocytic lacunar canalicular system using silver staining , 2007, Journal of Bone and Mineral Metabolism.

[15]  Minqi Li,et al.  Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. , 2007, Cell metabolism.

[16]  B. Lanske,et al.  Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice. , 2007, Matrix biology : journal of the International Society for Matrix Biology.

[17]  K. Okawa,et al.  Klotho converts canonical FGF receptor into a specific receptor for FGF23 , 2006, Nature.

[18]  L. Bonewald,et al.  Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism , 2006, Nature Genetics.

[19]  Stephen E. Harris,et al.  E11/gp38 Selective Expression in Osteocytes: Regulation by Mechanical Strain and Role in Dendrite Elongation , 2006, Molecular and Cellular Biology.

[20]  Y. Nabeshima.  Toward a better understanding of Klotho. , 2006, Science of aging knowledge environment : SAGE KE.

[21]  K. Rosenblatt,et al.  Regulation of Fibroblast Growth Factor-23 Signaling by Klotho* , 2006, Journal of Biological Chemistry.

[22]  K. Metsikkö,et al.  Isolated primary osteocytes express functional gap junctions in vitro , 2006, Cell and Tissue Research.

[23]  M. Noda,et al.  Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice. , 2005, Archives of histology and cytology.

[24]  N. Udagawa,et al.  Reduced osteoblastic population and defective mineralization in osteopetrotic (op/op) mice. , 2005, Micron.

[25]  Y. Nabeshima,et al.  Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho. , 2005, The Journal of clinical investigation.

[26]  S. Kato,et al.  Circulating FGF-23 Is Regulated by 1α,25-Dihydroxyvitamin D3 and Phosphorus in Vivo* , 2005, Journal of Biological Chemistry.

[27]  M. Razzaque,et al.  Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. , 2004, Matrix biology : journal of the International Society for Matrix Biology.

[28]  M. McKee,et al.  Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins , 2004, The Journal of cell biology.

[29]  Y. Takeuchi,et al.  Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. , 2004, The Journal of clinical investigation.

[30]  Y. Takeuchi,et al.  FGF‐23 Is a Potent Regulator of Vitamin D Metabolism and Phosphate Homeostasis , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[31]  T. Komori,et al.  Dentin Matrix Protein 1 Is Predominantly Expressed in Chicken and Rat Osteocytes But Not in Osteoblasts , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  T. Takano-Yamamoto,et al.  A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. , 2001, Bone.

[33]  I. Sekiya,et al.  Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy. , 2001, The Journal of endocrinology.

[34]  M Noda,et al.  High-resolution micro-computed tomography analyses of the abnormal trabecular bone structures in klotho gene mutant mice. , 2000, The Journal of endocrinology.

[35]  Kimimitsu Oda,et al.  A general method for rapid purification of soluble versions of glycosylphosphatidylinositol-anchored proteins expressed in insect cells: an application for human tissue-nonspecific alkaline phosphatase. , 1999, Journal of biochemistry.

[36]  M. Kuro-o,et al.  Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia. , 1999, The Journal of clinical investigation.

[37]  M. Noda,et al.  Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging. , 1998, The Journal of endocrinology.

[38]  Tadashi Kaname,et al.  Mutation of the mouse klotho gene leads to a syndrome resembling ageing , 1997, Nature.

[39]  R. Behringer,et al.  Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein , 1997, Nature.

[40]  Kimimitsu Oda,et al.  Immunolocalization of tissue non-specific alkaline phosphatase in mice , 1997, Histochemistry and Cell Biology.

[41]  P. Hauschka,et al.  Nucleation and inhibition of hydroxyapatite formation by mineralized tissue proteins. , 1996, The Biochemical journal.

[42]  N. Amizuka,et al.  Intracellular localization and translocation of 1 alpha, 25-dihydroxyvitamin D3 receptor in osteoblasts. , 1992, Archives of histology and cytology.

[43]  P. Price,et al.  Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. , 1985, The Journal of biological chemistry.

[44]  S. Carr,et al.  Calcium-dependent alpha-helical structure in osteocalcin. , 1982, Biochemistry.

[45]  P. Price,et al.  Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. Poser,et al.  Characterization of a gamma-carboxyglutamic acid-containing protein from bone. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[47]  J. Lian,et al.  Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[48]  Y. Nabeshima,et al.  alpha-Klotho: a regulator that integrates calcium homeostasis. , 2008, American journal of nephrology.

[49]  M. K. Knothe Tate,et al.  The osteocyte. , 2004, The international journal of biochemistry & cell biology.

[50]  M. Noda,et al.  Retardation in bone resorption after bone marrow ablation in klotho mutant mice. , 2000, Endocrinology.

[51]  M. Noda,et al.  Retardation in Bone Resorption after Bone Marrow Ablation in Klotho Mutant Mice1. , 2000, Endocrinology.

[52]  J. Klein-Nulend,et al.  MECHANOTRANSDUCTION IN BONE : ROLE OF THE LACUNOCANALICULAR NETWORK , 1999 .