A Rehabilitation-Internet-of-Things in the Home to Augment Motor Skills and Exercise Training

Although motor learning theory has led to evidence-based practices, few trials have revealed the superiority of one theory-based therapy over another after stroke. Nor have improvements in skills been as clinically robust as one might hope. We review some possible explanations, then potential technology-enabled solutions. Over the Internet, the type, quantity, and quality of practice and exercise in the home and community can be monitored remotely and feedback provided to optimize training frequency, intensity, and progression at home. A theory-driven foundation of synergistic interventions for walking, reaching and grasping, strengthening, and fitness could be provided by a bundle of home-based Rehabilitation Internet-of-Things (RIoT) devices. A RIoT might include wearable, activity-recognition sensors and instrumented rehabilitation devices with radio transmission to a smartphone or tablet to continuously measure repetitions, speed, accuracy, forces, and temporal spatial features of movement. Using telerehabilitation resources, a therapist would interpret the data and provide behavioral training for self-management via goal setting and instruction to increase compliance and long-term carryover. On top of this user-friendly, safe, and conceptually sound foundation to support more opportunity for practice, experimental interventions could be tested or additions and replacements made, perhaps drawing from virtual reality and gaming programs or robots. RIoT devices continuously measure the actual amount of quality practice; improvements and plateaus over time in strength, fitness, and skills; and activity and participation in home and community settings. Investigators may gain more control over some of the confounders of their trials and patients will have access to inexpensive therapies.

[1]  I. Torres-Aleman,et al.  Sedentary Life Impairs Self-Reparative Processes in the Brain: The Role of Serum Insulin-like Growth Factor-I , 2002, Reviews in the neurosciences.

[2]  A. Pollock,et al.  Treadmill Training and Body Weight Support for Walking After Stroke , 2003, The Cochrane database of systematic reviews.

[3]  B. Dobkin Rehabilitation and Functional Neuroimaging Dose-Response Trajectories for Clinical Trials , 2005, Neurorehabilitation and neural repair.

[4]  A. Wernig,et al.  Weight-supported treadmill vs over-ground training for walking after acute incomplete SCI , 2006, Neurology.

[5]  B. Dobkin,et al.  The Evolution of Walking-Related Outcomes Over the First 12 Weeks of Rehabilitation for Incomplete Traumatic Spinal Cord Injury: The Multicenter Randomized Spinal Cord Injury Locomotor Trial , 2007, Neurorehabilitation and neural repair.

[6]  T. George Hornby,et al.  Gait Training Strategies Utilized in Poststroke Rehabilitation: Are We Really Making a Difference? , 2007, Topics in stroke rehabilitation.

[7]  A. Kramer,et al.  Be smart, exercise your heart: exercise effects on brain and cognition , 2008, Nature Reviews Neuroscience.

[8]  T. Truelsen,et al.  ExStroke Pilot Trial of the effect of repeated instructions to improve physical activity after ischaemic stroke: a multinational randomised controlled clinical trial , 2009, BMJ : British Medical Journal.

[9]  J. Hidler,et al.  Multicenter Randomized Clinical Trial Evaluating the Effectiveness of the Lokomat in Subacute Stroke , 2009, Neurorehabilitation and neural repair.

[10]  R. Macko,et al.  Aerobic Exercise Improves Cognition and Motor Function Poststroke , 2009, Neurorehabilitation and neural repair.

[11]  J. Bragada,et al.  Net heart rate to prescribe physical activity in middle-aged to older active adults. , 2009, Journal of sports science & medicine.

[12]  Bruce H. Dobkin,et al.  International Randomized Clinical Trial, Stroke Inpatient Rehabilitation With Reinforcement of Walking Speed (SIRROWS), Improves Outcomes , 2010, Neurorehabilitation and neural repair.

[13]  Shyamal Patel,et al.  A review of wearable sensors and systems with application in rehabilitation , 2012, Journal of NeuroEngineering and Rehabilitation.

[14]  Bruce H Dobkin,et al.  The Promise of mHealth , 2011, Neurorehabilitation and neural repair.

[15]  Bruce H Dobkin,et al.  Body-weight-supported treadmill rehabilitation after stroke. , 2011, The New England journal of medicine.

[16]  C. Terwee,et al.  A systematic review of instruments assessing participation: challenges in defining participation. , 2011, Archives of physical medicine and rehabilitation.

[17]  A. James Barkovich,et al.  Eunice Kennedy Shriver National Institute of Child Health and Human Development Scientific Vision Workshop on Diagnostics and Therapeutics , 2011 .

[18]  B. Dobkin,et al.  Should Body Weight–Supported Treadmill Training and Robotic-Assistive Steppers for Locomotor Training Trot Back to the Starting Gate? , 2012, Neurorehabilitation and neural repair.

[19]  J. Krakauer,et al.  Getting Neurorehabilitation Right , 2012, Neurorehabilitation and neural repair.

[20]  Jon Sanford,et al.  Effects of Telerehabilitation on Physical Function and Disability for Stroke Patients: A Randomized, Controlled Trial , 2012, Stroke.

[21]  J. Deutsch,et al.  Virtual Reality for Stroke Rehabilitation , 2012 .

[22]  Audie A Atienza,et al.  Mobile health technology evaluation: the mHealth evidence workshop. , 2013, American journal of preventive medicine.

[23]  C. Foster,et al.  Face-to-face versus remote and web 2.0 interventions for promoting physical activity. , 2013, The Cochrane database of systematic reviews.

[24]  Justin Richards,et al.  Remote and web 2.0 interventions for promoting physical activity. , 2013, The Cochrane database of systematic reviews.

[25]  N. Lannin,et al.  Telerehabilitation services for stroke. , 2013, The Cochrane database of systematic reviews.

[26]  O. Celik,et al.  Systematic review of Kinect applications in elderly care and stroke rehabilitation , 2014, Journal of NeuroEngineering and Rehabilitation.

[27]  Andrea N. Reinkensmeyer,et al.  Retraining and assessing hand movement after stroke using the MusicGlove: comparison with conventional hand therapy and isometric grip training , 2014, Journal of NeuroEngineering and Rehabilitation.

[28]  B. Dobkin Wearable motion sensors to continuously measure real-world physical activities. , 2013, Current opinion in neurology.

[29]  P. Duncan,et al.  Adherence to Accelerometry Measurement of Community Ambulation Poststroke , 2013, Physical Therapy.

[30]  L. Swartz,et al.  Scaling Up mHealth: Where Is the Evidence? , 2013, PLoS medicine.

[31]  Cordula Werner,et al.  Electromechanical-Assisted Training for Walking After Stroke: Updated Evidence , 2013, Stroke.

[32]  Bambang Parmanto,et al.  Perspectives on the Evolution of Mobile (mHealth) Technologies and Application to Rehabilitation , 2014, Physical Therapy.

[33]  Gustavo Saposnik,et al.  iPad Technology for Home Rehabilitation after Stroke (iHOME): A Proof-of-Concept Randomized Trial , 2014, International journal of stroke : official journal of the International Stroke Society.

[34]  S. Carmichael,et al.  Plasticity in the Injured Brain , 2014, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[35]  S. Studenski,et al.  Prediction of responders for outcome measures of locomotor Experience Applied Post Stroke trial. , 2014, Journal of rehabilitation research and development.

[36]  G. Mead,et al.  University of Birmingham Sedentary Behavior in the First Year After Stroke , 2014 .

[37]  Matteo Pastorino,et al.  Preliminary Evaluation of a Personal Healthcare System Prototype for Cognitive eRehabilitation in a Living Assistance Domain , 2014, Sensors.

[38]  David Putrino,et al.  Telerehabilitation and emerging virtual reality approaches to stroke rehabilitation. , 2014, Current opinion in neurology.

[39]  Jacqui H Morris,et al.  Interventions to promote long-term participation in physical activity after stroke: a systematic review of the literature. , 2014, Archives of physical medicine and rehabilitation.

[40]  K. Kaufman,et al.  Validity of using tri-axial accelerometers to measure human movement - Part II: Step counts at a wide range of gait velocities. , 2014, Medical engineering & physics.

[41]  E. Roth,et al.  Physical Activity and Exercise Recommendations for Stroke Survivors: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , 2014, Stroke.

[42]  G. Kwakkel,et al.  What Is the Evidence for Physical Therapy Poststroke? A Systematic Review and Meta-Analysis , 2014, PloS one.

[43]  Sandro Scattareggia Marchese,et al.  Community-Based Exercise for Upper Limb Paresis , 2014, Neurorehabilitation and neural repair.

[44]  G. Mead,et al.  Interventions for improving upper limb function after stroke. , 2014, The Cochrane database of systematic reviews.

[45]  David J. Reinkensmeyer,et al.  The Manumeter: A Wearable Device for Monitoring Daily Use of the Wrist and Fingers , 2014, IEEE Journal of Biomedical and Health Informatics.

[46]  J. Reginster,et al.  Smart wearable body sensors for patient self-assessment and monitoring , 2014, Archives of Public Health.

[47]  G. Mead,et al.  Physical activity and exercise after stroke: review of multiple meaningful benefits. , 2014, Stroke.

[48]  Elise Dusseldorp,et al.  Combinations of techniques that effectively change health behavior: evidence from Meta-CART analysis. , 2014, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[49]  Sarah A. Moore,et al.  Effects of Community Exercise Therapy on Metabolic, Brain, Physical, and Cognitive Function Following Stroke , 2015, Neurorehabilitation and neural repair.

[50]  Janice J Eng,et al.  Capturing step counts at slow walking speeds in older adults: comparison of ankle and waist placement of measuring device. , 2015, Journal of rehabilitation medicine.

[51]  B. Dobkin,et al.  SIRRACT , 2015, Neurorehabilitation and neural repair.

[52]  Mary Galea,et al.  Telerehabilitation for persons with multiple sclerosis. , 2015, The Cochrane database of systematic reviews.

[53]  Steven C Cramer,et al.  Machine-Based, Self-guided Home Therapy for Individuals With Severe Arm Impairment After Stroke , 2015, Neurorehabilitation and neural repair.

[54]  Anson B. Rosenfeldt,et al.  The HAAPI (Home Arm Assistance Progression Initiative) Trial , 2015, Neurorehabilitation and neural repair.

[55]  W. McIlroy,et al.  Use of Accelerometer-Based Feedback of Walking Activity for Appraising Progress With Walking-Related Goals in Inpatient Stroke Rehabilitation , 2015, Neurorehabilitation and neural repair.

[56]  J W Krakauer,et al.  The proportional recovery rule for stroke revisited , 2015, Annals of neurology.

[57]  T. Jones,et al.  Combining Multiple Types of Motor Rehabilitation Enhances Skilled Forelimb Use Following Experimental Traumatic Brain Injury in Rats , 2015, Neurorehabilitation and neural repair.

[58]  C. Winstein,et al.  Translating the science into practice: shaping rehabilitation practice to enhance recovery after brain damage. , 2015, Progress in brain research.

[59]  C. Lang,et al.  Quantifying Real-World Upper-Limb Activity in Nondisabled Adults and Adults With Chronic Stroke , 2015, Neurorehabilitation and neural repair.

[60]  Lawrence R Wechsler,et al.  Advantages and limitations of teleneurology. , 2015, JAMA neurology.

[61]  Mike Allerhand,et al.  Sedentary behavior in the first year after stroke: a longitudinal cohort study with objective measures. , 2015, Archives of physical medicine and rehabilitation.

[62]  P. Requejo,et al.  Innovative Technologies for Rehabilitation and Health Promotion: What Is the Evidence? , 2015, Physical Therapy.

[63]  S. W. Phan,et al.  Singapore Tele-technology Aided Rehabilitation in Stroke (STARS) trial: protocol of a randomized clinical trial on tele-rehabilitation for stroke patients , 2015, BMC Neurology.

[64]  Dale Corbett,et al.  Exercise and Environmental Enrichment as Enablers of Task-Specific Neuroplasticity and Stroke Recovery , 2016, Neurotherapeutics.

[65]  M. Peeples,et al.  Evidence-Based mHealth Chronic Disease Mobile App Intervention Design: Development of a Framework , 2016, JMIR research protocols.

[66]  Stanley P. Azen,et al.  Effect of a Task-Oriented Rehabilitation Program on Upper Extremity Recovery Following Motor Stroke: The ICARE Randomized Clinical Trial. , 2016, JAMA.

[67]  Stewart G Trost,et al.  Evaluation of a Physical Activity Intervention for Adults With Brain Impairment , 2016, Neurorehabilitation and neural repair.

[68]  G. Kwakkel,et al.  Early Supported Discharge by Caregiver-Mediated Exercises and e-Health Support After Stroke: A Proof-of-Concept Trial , 2016, Stroke.

[69]  M. Levin,et al.  Maximizing post-stroke upper limb rehabilitation using a novel telerehabilitation interactive virtual reality system in the patient's home: study protocol of a randomized clinical trial. , 2016, Contemporary clinical trials.

[70]  Mary G. George,et al.  An International Standard Set of Patient-Centered Outcome Measures After Stroke , 2015, Journal of the Neurological Sciences.

[71]  D. Wade Rehabilitation – a new approach. Part four: a new paradigm, and its implications , 2016, Clinical rehabilitation.

[72]  M. Woodward,et al.  Mobile Telephone Text Messaging for Medication Adherence in Chronic Disease: A Meta-analysis. , 2016, JAMA internal medicine.

[73]  Pierrick Coupé,et al.  Early Fiber Number Ratio Is a Surrogate of Corticospinal Tract Integrity and Predicts Motor Recovery After Stroke , 2016, Stroke.

[74]  Kendra M. Cherry-Allen,et al.  Dose response of task‐specific upper limb training in people at least 6 months poststroke: A phase II, single‐blind, randomized, controlled trial , 2016, Annals of neurology.

[75]  P. Langhorne,et al.  Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT) , 2016, Neurology.

[76]  B. Dobkin Behavioral self-management strategies for practice and exercise should be included in neurologic rehabilitation trials and care. , 2016, Current opinion in neurology.

[77]  A. Geurts,et al.  Effects of Unilateral Upper Limb Training in Two Distinct Prognostic Groups Early After Stroke , 2016, Neurorehabilitation and neural repair.

[78]  E. Topol,et al.  State of Telehealth. , 2016, The New England journal of medicine.

[79]  Bruce H Dobkin,et al.  The Specific Requirements of Neural Repair Trials for Stroke , 2016, Neurorehabilitation and neural repair.

[80]  A. O’Cathain,et al.  Being Human: A Qualitative Interview Study Exploring Why a Telehealth Intervention for Management of Chronic Conditions Had a Modest Effect , 2016, Journal of medical Internet research.

[81]  Emil Jovanov,et al.  Teleexercise for Persons With Spinal Cord Injury: A Mixed-Methods Feasibility Case Series , 2016, JMIR rehabilitation and assistive technologies.

[82]  K. McPherson,et al.  Interventions to improve real-world walking after stroke: a systematic review and meta-analysis , 2017, Clinical rehabilitation.

[83]  Andreas Daffertshofer,et al.  Generalisability of the proportional recovery model for the upper extremity after an ischaemic stroke , 2017 .