PACRG, a protein linked to ciliary motility, mediates cellular signaling

Cilia are cellular projections that can be motile to generate fluid flow or nonmotile to enable signaling. Both forms are based on shared components, and proteins involved in ciliary motility, like PACRG, may also function in ciliary signaling. Caenorhabditis elegans PACRG acts in a subset of nonmotile cilia to influence a learning behavior and promote longevity.

[1]  D. Nicastro,et al.  Insights into the Structure and Function of Ciliary and Flagellar Doublet Microtubules , 2014, The Journal of Biological Chemistry.

[2]  C. Sung,et al.  The roles of evolutionarily conserved functional modules in cilia-related trafficking , 2013, Nature Cell Biology.

[3]  C. Sung,et al.  IGF-1 activates a cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression. , 2013, Developmental cell.

[4]  Laura J. Grundy,et al.  A database of C. elegans behavioral phenotypes , 2013, Nature Methods.

[5]  William R. Schafer,et al.  A Gap Junction Circuit Enhances Processing of Coincident Mechanosensory Inputs , 2013, Current Biology.

[6]  T. Thumberger,et al.  Ciliary and non-ciliary expression and function of PACRG during vertebrate development , 2012, Cilia.

[7]  N. Katsanis,et al.  Cilia in vertebrate development and disease , 2012, Development.

[8]  M. Leroux,et al.  cAMP and cGMP signaling: sensory systems with prokaryotic roots adopted by eukaryotic cilia. , 2010, Trends in cell biology.

[9]  C. Kenyon The genetics of ageing , 2010, Nature.

[10]  Robert A. Bloodgood Sensory reception is an attribute of both primary cilia and motile cilia , 2010, Journal of Cell Science.

[11]  P. Lockhart,et al.  Deletion of the Parkin co-regulated gene causes defects in ependymal ciliary motility and hydrocephalus in the quakingviable mutant mouse. , 2010, Human molecular genetics.

[12]  Yehuda Ben-Shahar,et al.  Motile Cilia of Human Airway Epithelia Are Chemosensory , 2009, Science.

[13]  K. Liao,et al.  Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes , 2009, Journal of Cell Science.

[14]  Madeline A Lancaster,et al.  The primary cilium as a cellular signaling center: lessons from disease. , 2009, Current opinion in genetics & development.

[15]  T. Tsumoto,et al.  Efhc1 deficiency causes spontaneous myoclonus and increased seizure susceptibility. , 2009, Human molecular genetics.

[16]  M. P. Healey,et al.  Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins , 2009, Journal of Cell Science.

[17]  Í. Lopes-Cendes,et al.  Expression Profile and Distribution of Efhc1 Gene Transcript During Rodent Brain Development , 2009, Journal of Molecular Neuroscience.

[18]  S. Rademakers,et al.  Gustatory plasticity in C. elegans involves integration of negative cues and NaCl taste mediated by serotonin, dopamine, and glutamate. , 2008, Learning & memory.

[19]  L. Amos The tektin family of microtubule-stabilizing proteins , 2008, Genome Biology.

[20]  S. Conticello The AID/APOBEC family of nucleic acid mutators , 2008, Genome Biology.

[21]  M. Barr,et al.  Sensory roles of neuronal cilia: cilia development, morphogenesis, and function in C. elegans. , 2008, Frontiers in bioscience : a journal and virtual library.

[22]  Takashi Ikeda Parkin‐co‐regulated gene (PACRG) product interacts with tubulin and microtubules , 2008, FEBS letters.

[23]  P. Lockhart,et al.  Regional and cellular localisation of Parkin Co-Regulated Gene in developing and adult mouse brain , 2008, Brain Research.

[24]  K. Yamakawa,et al.  Sequential expression of Efhc1/myoclonin1 in choroid plexus and ependymal cell cilia. , 2008, Biochemical and biophysical research communications.

[25]  Aaron J. Bell,et al.  Evolution and persistence of the cilium. , 2007, Cell motility and the cytoskeleton.

[26]  R. Kamiya,et al.  Axonemal localization of Chlamydomonas PACRG, a homologue of the human Parkin-coregulated gene product. , 2007, Cell motility and the cytoskeleton.

[27]  K. Anderson,et al.  Cilia and developmental signaling. , 2007, Annual review of cell and developmental biology.

[28]  W. Schafer,et al.  Caenorhabditis elegans TRPA-1 functions in mechanosensation , 2007, Nature Neuroscience.

[29]  G. Jansen,et al.  Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans. , 2007, Developmental biology.

[30]  P. Satir,et al.  Sensory Cilia and Integration of Signal Transduction in Human Health and Disease , 2007, Traffic.

[31]  J. Scholey,et al.  The WD repeat-containing protein IFTA-1 is required for retrograde intraflagellar transport. , 2006, Molecular biology of the cell.

[32]  Cori Bargmann Chemosensation in C. elegans. , 2006, WormBook : the online review of C. elegans biology.

[33]  B. Yoder,et al.  IFTA-2 is a conserved cilia protein involved in pathways regulating longevity and dauer formation in Caenorhabditis elegans , 2006, Journal of Cell Science.

[34]  R. E. Stephens,et al.  Tektin interactions and a model for molecular functions. , 2006, Experimental cell research.

[35]  D. Fay Genetic mapping and manipulation: chapter 2--Two-point mapping with genetic markers. , 2006, WormBook : the online review of C. elegans biology.

[36]  Suzanne Rademakers,et al.  Antagonistic sensory cues generate gustatory plasticity in Caenorhabditis elegans , 2006, The EMBO journal.

[37]  K. Gull,et al.  The Parkin co-regulated gene product, PACRG, is an evolutionarily conserved axonemal protein that functions in outer-doublet microtubule morphogenesis , 2005, Journal of Cell Science.

[38]  B. Yoder,et al.  The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception , 2005, Journal of Cell Science.

[39]  J. Scholey,et al.  Functional coordination of intraflagellar transport motors , 2005, Nature.

[40]  G. Pazour,et al.  Proteomic analysis of a eukaryotic cilium , 2005, The Journal of cell biology.

[41]  J. Yates,et al.  Proteomic Analysis of Isolated Chlamydomonas Centrioles Reveals Orthologs of Ciliary-Disease Genes , 2005, Current Biology.

[42]  Gary Ruvkun,et al.  Analysis of xbx genes in C. elegans , 2005, Development.

[43]  Jeffrey C. Smith,et al.  Robust method for proteome analysis by MS/MS using an entire translated genome: demonstration on the ciliome of Tetrahymena thermophila. , 2005, Journal of proteome research.

[44]  W. Marshall,et al.  Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[45]  K. Guan,et al.  Expression and phenotype analysis of the nephrocystin-1 and nephrocystin-4 homologs in Caenorhabditis elegans. , 2005, Journal of the American Society of Nephrology : JASN.

[46]  M. Hirono,et al.  The mouse ortholog of EFHC1 implicated in juvenile myoclonic epilepsy is an axonemal protein widely conserved among organisms with motile cilia and flagella , 2005, FEBS letters.

[47]  J. Apfeld,et al.  The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans. , 2004, Genes & development.

[48]  J. Scholey,et al.  Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons , 2004, Nature Cell Biology.

[49]  N. Iguchi,et al.  Mice Deficient in the Axonemal Protein Tektin-t Exhibit Male Infertility and Immotile-Cilium Syndrome Due to Impaired Inner Arm Dynein Function , 2004, Molecular and Cellular Biology.

[50]  M. T. Medina,et al.  Mutations in EFHC1 cause juvenile myoclonic epilepsy , 2004, Nature Genetics.

[51]  S. R. Wicks,et al.  Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. , 2004, Genes & development.

[52]  C. Bishop,et al.  Deletion of the Parkin coregulated gene causes male sterility in the quaking(viable) mouse mutant. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[53]  Shankar Subramaniam,et al.  Decoding Cilia Function Defining Specialized Genes Required for Compartmentalized Cilia Biogenesis , 2004, Cell.

[54]  Tanya M. Teslovich,et al.  Comparative Genomics Identifies a Flagellar and Basal Body Proteome that Includes the BBS5 Human Disease Gene , 2004, Cell.

[55]  C. Kenyon,et al.  Regulation of C. elegans Longevity by Specific Gustatory and Olfactory Neurons , 2004, Neuron.

[56]  R. Linck,et al.  Protofilament ribbon compartments of ciliary and flagellar microtubules. , 2003, Protist.

[57]  M. Hirono,et al.  Rib72, a Conserved Protein Associated with the Ribbon Compartment of Flagellar A-microtubules and Potentially Involved in the Linkage between Outer Doublet Microtubules* , 2003, The Journal of Biological Chemistry.

[58]  P. Sengupta,et al.  Regulation of Body Size and Behavioral State of C. elegans by Sensory Perception and the EGL-4 cGMP-Dependent Protein Kinase , 2002, Neuron.

[59]  Cori Bargmann,et al.  Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli , 2002, Nature.

[60]  Cori Bargmann,et al.  Combinatorial Expression of TRPV Channel Proteins Defines Their Sensory Functions and Subcellular Localization in C. elegans Neurons , 2002, Neuron.

[61]  L. Ostrowski,et al.  A Proteomic Analysis of Human Cilia , 2002, Molecular & Cellular Proteomics.

[62]  R. Plasterk,et al.  The G‐protein γ subunit gpc‐1 of the nematode C.elegans is involved in taste adaptation , 2002 .

[63]  Raymond Y. N. Lee,et al.  Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway , 2001, Current Biology.

[64]  S. R. Wicks,et al.  CHE-3, a cytosolic dynein heavy chain, is required for sensory cilia structure and function in Caenorhabditis elegans. , 2000, Developmental biology.

[65]  J. Thomas,et al.  The RFX-type transcription factor DAF-19 regulates sensory neuron cilium formation in C. elegans. , 2000, Molecular cell.

[66]  J. Apfeld,et al.  Regulation of lifespan by sensory perception in Caenorhabditis elegans , 1999, Nature.

[67]  R. Plasterk,et al.  The complete family of genes encoding G proteins of Caenorhabditis elegans , 1999, Nature Genetics.

[68]  Cori Bargmann,et al.  The Gα Protein ODR-3 Mediates Olfactory and Nociceptive Function and Controls Cilium Morphogenesis in C. elegans Olfactory Neurons , 1998, Neuron.

[69]  H. Bussey,et al.  Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1 , 1997, Science.

[70]  J. Ahringer,et al.  G Proteins Are Required for Spatial Orientation of Early Cell Cleavages in C. elegans Embryos , 1996, Cell.

[71]  J. Kaplan,et al.  Synaptic code for sensory modalities revealed by C. elegans GLR-1 glutamate receptor , 1995, Nature.

[72]  C. Kenyon,et al.  A C. elegans mutant that lives twice as long as wild type , 1993, Nature.

[73]  H. Horvitz,et al.  A dual mechanosensory and chemosensory neuron in Caenorhabditis elegans. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[74]  Cori Bargmann,et al.  Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans , 1991, Neuron.

[75]  J. N. Thomson,et al.  Mutant sensory cilia in the nematode Caenorhabditis elegans. , 1986, Developmental biology.

[76]  M. Klass,et al.  Aging in the nematode Caenorhabditis elegans: Major biological and environmental factors influencing life span , 1977, Mechanisms of Ageing and Development.

[77]  J. Scholey,et al.  The sensory cilia of Caenorhabditis elegans. , 2007, WormBook : the online review of C. elegans biology.

[78]  R. Plasterk,et al.  The G-protein gamma subunit gpc-1 of the nematode C.elegans is involved in taste adaptation. , 2002, The EMBO journal.