Intensive red blood cell transfusions and risk of alloimmunization

Exposure to allogenic red blood cells (RBCs) may lead to formation of antibodies against nonself‐antigens in transfused patients. While alloimmunization rates are known to increase with the number of transfusions, the transfusion course in patients can vary from receiving multiple units during a single transfusion event or getting them dispersed over a long(er) period. In this study we compared the immunization risk between different transfusion intensities.

[1]  R. Ware,et al.  Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management. , 2012, Blood.

[2]  T. Wen,et al.  Risk factors and outcomes of massive red blood cell transfusion following living donor liver transplantation , 2012, Journal of digestive diseases.

[3]  E. Hod,et al.  Transfusion in the absence of inflammation induces antigen-specific tolerance to murine RBCs. , 2012, Blood.

[4]  S. Cessie,et al.  Red‐blood‐cell alloimmunization and number of red‐blood‐cell transfusions , 2012, Vox sanguinis.

[5]  P. Cameron,et al.  The definition of massive transfusion in trauma: a critical variable in examining evidence for resuscitation , 2011, European journal of emergency medicine : official journal of the European Society for Emergency Medicine.

[6]  Sebastian Schneeweiss,et al.  A basic study design for expedited safety signal evaluation based on electronic healthcare data , 2010, Pharmacoepidemiology and drug safety.

[7]  D. Triulzi,et al.  Does a febrile reaction to platelets predispose recipients to red blood cell alloimmunization? , 2009, Transfusion.

[8]  S. Sloan,et al.  Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders. , 2008, Blood.

[9]  A. Sauaia,et al.  Postinjury life threatening coagulopathy: is 1:1 fresh frozen plasma:packed red blood cells the answer? , 2008, The Journal of trauma.

[10]  J. Vandenbroucke,et al.  Clinical predictors of alloimmunization after red blood cell transfusion , 2007, Transfusion.

[11]  C. Hillyer,et al.  Inflammation enhances consumption and presentation of transfused RBC antigens by dendritic cells. , 2007, Blood.

[12]  C. Hillyer,et al.  Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cells , 2006, Transfusion.

[13]  F. Roudot-thoraval,et al.  Relative immunogenicity of Fya and K antigens in a Caucasian population, based on HLA class II restriction analysis , 2006, Transfusion.

[14]  D. Demetriades,et al.  Blood transfusion in critically injured patients: a prospective study. , 2006, Injury.

[15]  M. Busch,et al.  Microchimerism in transfused trauma patients is associated with diminished donor-specific lymphocyte response. , 2005, The Journal of trauma.

[16]  I. Pallister.  Current concepts of the inflammatory response after major trauma: an update. , 2005, Injury.

[17]  M. Busch,et al.  Blood transfusion is associated with donor leukocyte microchimerism in trauma patients. , 2004, The Journal of trauma.

[18]  J. Dunne,et al.  Allogenic blood transfusion in the first 24 hours after trauma is associated with increased systemic inflammatory response syndrome (SIRS) and death. , 2004, Surgical infections.

[19]  L. Dümbgen,et al.  Probability of anti‐D development in D− patients receiving D+ RBCs , 2003, Transfusion.

[20]  P. Giannoudis,et al.  Current concepts of the inflammatory response after major trauma: an update. , 2003, Injury.

[21]  E. Vamvakas,et al.  Meta‐analysis of randomized controlled trials comparing the risk of postoperative infection between recipients of allogeneic and autologous blood transfusion , 2002, Vox sanguinis.

[22]  P. Matzinger,et al.  An innate sense of danger. , 1998, Seminars in immunology.

[23]  V. Kunst,et al.  Incidence of red cell antibodies after multiple blood transfusion , 1990, Transfusion.

[24]  B. Griffith,et al.  Low rate of Rhesus immunization from Rh-incompatible blood transfusions during liver and heart transplant surgery. , 1989, Transplantation.

[25]  B. Rush,et al.  Rh(D) IMMUNIZATION AFTER MASSIVE TRANSFUSION OF Rh(D)–POSITIVE BLOOD , 1974, The Medical journal of Australia.

[26]  M. R. Mickey,et al.  Effect of blood transfusions on subsequent kidney transplants. , 1973, Transplantation proceedings.

[27]  R. O'Connor,et al.  Studies on Rh Prophylaxis , 1971 .

[28]  R. O'Connor,et al.  Studies on Rh prophylaxis. II. Rh immune prophylaxis after transfusion with Rh-positive blood. , 1971, Transfusion.