Basal Cell Carcinoma of the Head and Neck: Identification of Predictors of Recurrence

The goal of this retrospective study was to identify factors that predict the recurrence of basal cell carcinoma of the head and neck. We reviewed the medical records of 165 patients who had undergone a wide surgical excision (negative margins) of one or more basal cell carcinomas of the head and neck. Univariate analysis revealed that recurrence was significantly influenced by the patient's gender (p<0.01), the presence of preoperative risk factors (p<0.05), the presence of multiple lesions (p<0.01), and their histopathologic subtype (p<0.05). Multivariate analysis revealed that the best predictors of recurrence were the presence of preoperative risk factors and the presence of multiple lesions (p<0.01); the lesion's histologic subtype approached but did not reach statistical significance in predicting recurrence (p=0.06).

[1]  I. Fleming,et al.  Principles of management of basal and squamous cell carcinoma of the skin , 1995, Cancer.

[2]  Y. Eliezri,et al.  Cancer Recurrence Following Mohsʼ Micrographic Surgery: A Mechanism of Tumor Persistence , 1994 .

[3]  A. Kopf,et al.  Recurrence rates of treated basal cell carcinomas. , 1993, The Journal of dermatologic surgery and oncology.

[4]  A. Wennberg,et al.  Treatment of aggressive basal cell carcinoma with intralesional interferon: evaluation of efficacy by Mohs surgery. , 1992, Journal of the American Academy of Dermatology.

[5]  Philip R. Cohen,et al.  Cancer recurrence following Mohs micrographic surgery: a mechanism of tumor persistence. , 1992, Plastic and reconstructive surgery.

[6]  R. Stern,et al.  Risk of subsequent basal cell carcinoma and squamous cell carcinoma of the skin among patients with prior skin cancer. Skin Cancer Prevention Study Group. , 1992, JAMA.

[7]  B. Safai,et al.  Basal cell carcinomas and lymphoma: biologic behavior and associated factors in sixty-three patients. , 1988, Journal of the American Academy of Dermatology.

[8]  R. Wagner,et al.  Multifocal recurrent basal cell carcinoma following primary tumor treatment by electrodesiccation and curettage. , 1987, Journal of the American Academy of Dermatology.

[9]  June K. Robinson,et al.  Risk of developing another basal cell carcinoma. A 5‐year prospective study , 1987, Cancer.

[10]  Dellon Al.  Histologic study of recurrent basal cell carcinoma. , 1985 .

[11]  A. Ross,et al.  Prediction of recurrence in incompletely excised basal cell carcinoma. , 1985, Plastic and reconstructive surgery.

[12]  A. Dellon.  Histologic study of recurrent basal cell carcinoma. , 1985, Plastic and reconstructive surgery.

[13]  A. Kopf,et al.  Multivariate risk score for recurrence of cutaneous basal cell carcinomas. , 1983, Archives of dermatology.

[14]  G. Jacobs,et al.  Prediction of aggressive behavior in basal cell carcinoma , 1982, Cancer.

[15]  W. Sause,et al.  Radiation therapy for skin cancer. , 1980, The Western journal of medicine.

[16]  H. Levine,et al.  Basal Cell Carcinoma of the Head and Neck: Identification of the High Risk Patient , 1980, The Laryngoscope.

[17]  H. Zarem,et al.  Recurrent basal cell carcinoma. A review concerning the incidence, behavior, and management of recurrent basal cell carcinoma, with emphasis on the incompletely excised lesion. , 1980, Plastic and reconstructive surgery.

[18]  W. Panje,et al.  The influence of embryology of the mid‐face on the spread of epithelial malignancies , 1979, The Laryngoscope.

[19]  C. Sakura,et al.  Comparison of Treatment Modalities for Recurrent Basal Cell Carcinoma , 1979, Plastic and reconstructive surgery.

[20]  E. Epstein.  Value of follow-up after treatment of basal cell carcinoma. , 1973, Archives of Dermatology.

[21]  A. Kopf,et al.  The recurrent basal cell epithelioma. A study of 100 cases of recurrent, re-treated basal cell epitheliomas. , 1971, Archives of dermatology.

[22]  M. Spira,et al.  Basal Cell Carcinoma: A Statistical Approach to Rational Management , 1967, Plastic and reconstructive surgery.

[23]  H. Teloh.  Correlation of rate of growth with histologic characteristics of basal cell carcinoma. , 1953, A.M.A. archives of dermatology and syphilology.