Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
暂无分享,去创建一个
Klaus-Armin Nave | K. Nave | M. Klugmann | V. Tuohy | L. Klein | B. Kyewski | Bruno Kyewski | Matthias Klugmann | Ludger Klein | V K Tuohy
[1] H. Wekerle. Experimental autoimmune encephalomyelitis as a model of immune-mediated CNS disease , 1993, Current Opinion in Neurobiology.
[2] R. Kinkel,et al. Diversity and plasticity of self recognition during the development of multiple sclerosis. , 1997, The Journal of clinical investigation.
[3] D. Hanahan,et al. Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity. , 1998, Current opinion in immunology.
[4] B. Kyewski,et al. Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation , 1986, The Journal of experimental medicine.
[5] F. Bloom,et al. Splice site selection in the proteolipid protein (PLP) gene transcript and primary structure of the DM-20 protein of central nervous system myelin. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[6] M. Zhao,et al. Active and passive experimental autoimmune encephalomyelitis in strain 129/J (H‐2b) mice , 1996, Journal of neuroscience research.
[7] Kathleen M. Smith,et al. Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. , 1997, International immunology.
[8] S. Miller,et al. Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis , 1995, The Journal of experimental medicine.
[9] L. Klein,et al. CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium , 1998, The Journal of experimental medicine.
[10] B. Stockinger. T lymphocyte tolerance: from thymic deletion to peripheral control mechanisms. , 1999, Advances in immunology.
[11] S. Miller,et al. Evolution of the T‐Cell Repertoire during the Course of Experimental Immune‐Mediated Demyelinating Diseases , 1995, Immunological reviews.
[12] V. Tuohy,et al. Sequence 104–117 of myelin proteolipid protein is a cryptic encephalitogenic T cell determinant for SJL/J mice , 1995, Journal of Neuroimmunology.
[13] John T. Chang,et al. Regulation of Interleukin (IL)-12 Receptor β2 Subunit Expression by Endogenous IL-12: A Critical Step in the Differentiation of Pathogenic Autoreactive T Cells , 1999, The Journal of experimental medicine.
[14] T. Hunkapiller,et al. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. , 1998, Immunity.
[15] V. Kuchroo,et al. Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. , 1992, Journal of immunology.
[16] Paul V. Lehmann,et al. Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire , 1998, The Journal of experimental medicine.
[17] V. Tuohy,et al. Spontaneous Regression of Primary Autoreactivity during Chronic Progression of Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis , 1999, The Journal of experimental medicine.
[18] D. Wraith,et al. Mechanisms of central and peripehral T‐cell tolerance: lessons from experimental models of multiple sclerosis , 1999, Immunological reviews.
[19] R. Kinkel,et al. The epitope spreading cascade during progression of experimental autoimmune encephalomyelitis and multiple sclerosis , 1998, Immunological reviews.
[20] R. Sobel,et al. Myelin proteolipid protein-induced experimental allergic encephalomyelitis. Variations of disease expression in different strains of mice. , 1988, Journal of immunology.
[21] D. McFarlin,et al. Immunological aspects of demyelinating diseases. , 1992, Annual review of immunology.
[22] V. Tuohy,et al. A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease , 1996, The Journal of experimental medicine.
[23] J. Alferink,et al. Peripheral T‐cell tolerance: the contribution of permissive T‐cell migration into parenchymal tissues of the neonate , 1999, Immunological reviews.
[24] J. Seidman,et al. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. , 1996, Journal of immunology.
[25] H. Lassmann,et al. The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus. , 1997, International immunology.
[26] J. Seidman,et al. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2 , 1999, Nature Genetics.
[27] A. Sette,et al. T cell recognition of immunodominant and cryptic proteolipid protein epitopes in humans , 1994, Journal of Neuroimmunology.
[28] R. Sobel,et al. Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. , 1989, Journal of immunology.
[29] J. Todd,et al. New genetic loci that control susceptibility and symptoms of experimental allergic encephalomyelitis in inbred mice. , 1998, Journal of immunology.
[30] S. Miller,et al. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading , 1997, Nature Medicine.
[31] A. Sette,et al. Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. , 1996, Journal of immunology.
[32] Camillo Ricordi,et al. The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes , 1997, Nature Genetics.
[33] P. Charukamnoetkanok,et al. Thymic expression of autoantigens correlates with resistance to autoimmune disease. , 1997, Journal of immunology.
[34] V. Lotteau,et al. CD4 T cell tolerance to nuclear proteins induced by medullary thymic epithelium. , 1996, Immunity.
[35] H. McFarland,et al. T cell recognition of myelin proteolipid protein and myelin proteolipid protein peptides in the peripheral blood of multiple sclerosis and control subjects , 1998, Journal of Neuroimmunology.
[36] M. Juan,et al. Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens. , 1998, Journal of immunology.
[37] J. Todd,et al. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus , 1997, Nature Genetics.
[38] J. Bluestone,et al. The functional significance of epitope spreading and its regulation by co‐stimulatory molecules , 1998, Immunological reviews.
[39] H. Wekerle,et al. The Shaping of the Brain–Specific T Lymphocyte Repertoire in the Thymus , 1996, Immunological reviews.
[40] K. Nave,et al. Assembly of CNS Myelin in the Absence of Proteolipid Protein , 1997, Neuron.
[41] H. von Boehmer,et al. Development and selection of T cells: facts and puzzles. , 1995, Advances in immunology.
[42] D. Mason,et al. Intrathymic expression of genes involved in organ specific autoimmune disease. , 1998, Journal of autoimmunity.
[43] R. Voskuhl. Myelin protein expression in lymphoid tissues: implications for peripheral tolerance , 1998, Immunological reviews.
[44] C. Campagnoni,et al. The major myelin protein genes are expressed in the human thymus , 1996, Journal of neuroscience research.
[45] L Steinman,et al. Multiple Sclerosis: A Coordinated Immunological Attack against Myelin in the Central Nervous System , 1996, Cell.