Homoharringtonine induces apoptosis of endothelium and down-regulates VEGF expression of K562 cells

[1]  B. Dörken,et al.  Apoptotic response to homoharringtonine in human wt p53 leukemic cells is independent of reactive oxygen species generation and implicates Bax translocation, mitochondrial cytochrome c release and caspase activation , 2001, Leukemia.

[2]  S. Rafii,et al.  Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis. , 2000, Blood.

[3]  W. Berdel,et al.  Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia. , 2000, Blood.

[4]  J. Folkman,et al.  Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. , 2000, Cancer research.

[5]  D. Ribatti,et al.  Antiangiogenesis Is Produced by Nontoxic Doses of Vinblastine , 1999 .

[6]  B. Cheson,et al.  Sequential homoharringtonine and interferon-alpha in the treatment of early chronic phase chronic myelogenous leukemia. , 1999, Blood.

[7]  T. Grogan,et al.  Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies. , 1999, Cancer research.

[8]  S. Ergün,et al.  Vascular endothelial growth factor, a possible paracrine growth factor in human acute myeloid leukemia. , 1997, Blood.

[9]  S. Sallan,et al.  Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia. , 1997, The American journal of pathology.

[10]  R. Zittoun,et al.  Homoharringtonine: an effective new natural product in cancer chemotherapy. , 1995, Bulletin du cancer.

[11]  M. Andreeff,et al.  Homoharringtonine therapy induces responses in patients with chronic myelogenous leukemia in late chronic phase. , 1995, Blood.

[12]  T. Ahmed,et al.  Homoharringtonine is safe and effective for patients with acute myelogenous leukemia. , 1992, Leukemia.

[13]  G. Karpova,et al.  Alkaloid homoharringtonine inhibits polypeptide chain elongation on human ribosomes on the step of peptide bond formation , 1989, FEBS letters.