Depression and IL-6 blood plasma concentrations in advanced cancer patients.

The authors explored the relationship between depression and interleukin-6 (IL-6) blood plasma concentrations among advanced-stage cancer patients. Seventy-three patients with advanced cancer were rated on depression with the Hamilton Rating Scale for Depression and gave blood to be assayed for blood plasma concentration of IL-6. Initial results found no correlation between depression and IL-6. Subsequent analyses found that among those whose blood was drawn within 48 hours of interview completion, depression and IL-6 were highly correlated. Future studies focusing on the relationship between immune functioning and depression must be particularly vigilant regarding methodological issues.

[1]  J. Kiecolt-Glaser,et al.  Psychoneuroimmunology: psychological influences on immune function and health. , 2002, Journal of consulting and clinical psychology.

[2]  C. Nemeroff,et al.  Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings. , 2001, The American journal of psychiatry.

[3]  H. Cohen,et al.  Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community , 1999, Journal of the American Geriatrics Society.

[4]  H. Cohen,et al.  Attendance at Religious Services, Interleukin-6, and other Biological Parameters of Immune Function in Older Adults , 1997, International journal of psychiatry in medicine.

[5]  J. Fahey,et al.  Depression in caregivers of demented patients is associated with altered immunity: impaired proliferative capacity, increased CD8+, and a decline in lymphocytes with surface signal transduction molecules (CD38+) and a cytotoxicity marker (CD56+ CD8+) , 1995, Clinical and experimental immunology.

[6]  J. Kiecolt-Glaser,et al.  Chronic stress, social support, and persistent alterations in the natural killer cell response to cytokines in older adults. , 1994, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[7]  J. Kiecolt-Glaser,et al.  Psychoneuroimmunology: can psychological interventions modulate immunity? , 1992, Journal of consulting and clinical psychology.

[8]  P. Mantegazza,et al.  Corticotropin releasing hormone, interleukin-1α, and tumor necrosis factor-α share characteristics of stress mediators , 1991, Brain Research.

[9]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[10]  M. Hamilton A RATING SCALE FOR DEPRESSION , 1960, Journal of neurology, neurosurgery, and psychiatry.