A computerized system for the detection and analysis of spontaneously occurring synaptic potentials

A computerized system is described which converts analog, high-gain intracellular records from alpha motoneurons to digital data which are displayed on a graphics terminal and stored on magnetic media. Spontaneously occurring synaptic potentials are automatically detected and a quantitative analysis of their waveform parameters is computer-generated.

[1]  F. Morales,et al.  Repetitive synaptic potentials responsible for inhibition of spinal cord motoneurons during active sleep , 1982, Experimental Neurology.

[2]  P. G. Nelson,et al.  Synaptic Activity in Motoneurons during Natural Stimulation of Muscle Spindles , 1966, Science.

[3]  F. Morales,et al.  Intracellular recording from spinal cord motoneurons in the chronic cat , 1981, Physiology & Behavior.

[4]  G. Hirst,et al.  Some properties of spontaneous excitatory junction potentials recorded from arterioles of guinea‐pigs. , 1980, The Journal of physiology.

[5]  R. Burke,et al.  Electrotonic characteristics of alpha motoneurones of varying size , 1971, The Journal of physiology.

[6]  E Jankowska,et al.  Synaptic actions of single interneurones mediating reciprocal Ia inhibition of motoneurones , 1972, The Journal of physiology.

[7]  Stephen Redman,et al.  The recovery of a random variable from a noisy record with application to the study of fluctuations in synaptic potentials , 1980, Journal of Neuroscience Methods.

[8]  Louis J. DeFelice,et al.  Introduction to membrane noise , 1981 .

[9]  L. Van Keulen,et al.  Autogenetic recurrent inhibition of individual spinal motoneurones of the cat , 1981, Neuroscience Letters.

[10]  B. Katz,et al.  A study of spontaneous miniature potentials in spinal motoneurones , 1963, The Journal of physiology.

[11]  W. Rall Distinguishing theoretical synaptic potentials computed for different soma-dendritic distributions of synaptic input. , 1967, Journal of neurophysiology.

[12]  H. Anton Calculus with analytic geometry , 1992 .

[13]  M. Kuno,et al.  Factors responsible for multiple discharge of neurons in Clarke's column. , 1968, Journal of neurophysiology.

[14]  J. Eccles,et al.  The recording of potentials from motoneurones with an intracellular electrode , 1952, The Journal of physiology.

[15]  E Henneman,et al.  Terminals of single Ia fibers: location, density, and distribution within a pool of 300 homonymous motoneurons. , 1971, Journal of neurophysiology.

[16]  R. Nicoll,et al.  Spontaneous inhibitory post-synaptic potentials in hippocampus: Mechanism for tonic inhibition , 1980, Brain Research.

[17]  J. Blankenship,et al.  Analysis of spontaneous subthreshold activity in spinal motoneurons of the cat. , 1968, Journal of neurophysiology.

[18]  R E Burke,et al.  Composite nature of the monosynaptic excitatory postsynaptic potential. , 1967, Journal of neurophysiology.