A non-hallucinogenic psychedelic analogue with therapeutic potential

[1]  D. E. Olson,et al.  The iboga enigma: the chemistry and neuropharmacology of iboga alkaloids and related analogs. , 2020, Natural product reports.

[2]  D. E. Olson,et al.  Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies. , 2020, Journal of medicinal chemistry.

[3]  J. Wallach,et al.  Correlation between the potency of hallucinogens in the mouse head-twitch response assay and their behavioral and subjective effects in other species , 2020, Neuropharmacology.

[4]  J. Peters,et al.  Acute ovarian hormone treatment in freely cycling female rats regulates distinct aspects of heroin seeking , 2019, Learning & memory.

[5]  Michael J. Keiser,et al.  Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation , 2019, Nature Communications.

[6]  A. Flenniken,et al.  A Comprehensive Plasma Metabolomics Dataset for a Cohort of Mouse Knockouts within the International Mouse Phenotyping Consortium , 2019, bioRxiv.

[7]  Mitchell H. Murdock,et al.  Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced spine formation , 2019, Science.

[8]  G. Seoane,et al.  Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits , 2019, Front. Pharmacol..

[9]  P. Lein,et al.  Teratological and Behavioral Screening of the National Toxicology Program 91-Compound Library in Zebrafish (Danio rerio) , 2018, Toxicological sciences : an official journal of the Society of Toxicology.

[10]  D. E. Olson.  Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics , 2018, Journal of experimental neuroscience.

[11]  P. Witt-Enderby,et al.  DARK Classics in Chemical Neuroscience: Ibogaine. , 2018, ACS chemical neuroscience.

[12]  J. Peters,et al.  Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine-seeking , 2018, The Journal of Neuroscience.

[13]  D. E. Olson,et al.  Dark Classics in Chemical Neuroscience: N, N-Dimethyltryptamine (DMT). , 2018, ACS chemical neuroscience.

[14]  D. E. Olson,et al.  Psychedelics Promote Structural and Functional Neural Plasticity , 2018, Cell reports.

[15]  Bonifasius Putera Sampurna,et al.  A Simple ImageJ-Based Method to Measure Cardiac Rhythm in Zebrafish Embryos , 2018 .

[16]  C. Frampton,et al.  Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study , 2018, The American journal of drug and alcohol abuse.

[17]  Jun B. Ding,et al.  Selective activation of parvalbumin interneurons prevents stress-induced synapse loss and perceptual defects , 2017, Molecular Psychiatry.

[18]  Anabella Villalobos,et al.  Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery. , 2016, ACS chemical neuroscience.

[19]  Victoria Phoumthipphavong,et al.  Longitudinal effects of ketamine on dendritic architecture in vivo in the mouse medial frontal cortex , , Ketamine and structural plasticity , 2016 .

[20]  Xiaoguang Li,et al.  Deconstructing the Iboga Alkaloid Skeleton: Potentiation of FGF2-induced Glial Cell Line-Derived Neurotrophic Factor Release by a Novel Compound. , 2016, ACS chemical biology.

[21]  Matthew W. Johnson,et al.  Classic hallucinogens in the treatment of addictions , 2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[22]  J. Kornhuber,et al.  “Herbal seizures” – atypical symptoms after ibogaine intoxication: a case report , 2015, Journal of Medical Case Reports.

[23]  Maria F. Sassano,et al.  PRESTO-TANGO: an open-source resource for interrogation of the druggable human GPCR-ome , 2015, Nature Structural &Molecular Biology.

[24]  K. Hilber,et al.  The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation , 2015, Molecules.

[25]  K. Hilber,et al.  Anti‐addiction drug ibogaine inhibits hERG channels: a cardiac arrhythmia risk , 2014, Addiction biology.

[26]  O. Kudlacek,et al.  Mechanism of hERG Channel Block by the Psychoactive Indole Alkaloid Ibogaine , 2014, The Journal of Pharmacology and Experimental Therapeutics.

[27]  Philipp J. Keller,et al.  Whole-brain functional imaging at cellular resolution using light-sheet microscopy , 2013, Nature Methods.

[28]  E. Darcq,et al.  Chromatin remodeling — a novel strategy to control excessive alcohol drinking , 2013, Translational Psychiatry.

[29]  K. Alper,et al.  Fatalities Temporally Associated with the Ingestion of Ibogaine , 2012, Journal of forensic sciences.

[30]  S. D. Glick,et al.  Noribogaine, but not 18‐MC, exhibits similar actions as ibogaine on GDNF expression and ethanol self‐administration , 2010, Addiction biology.

[31]  Willie F. Tobin,et al.  Rapid formation and selective stabilization of synapses for enduring motor memories , 2009, Nature.

[32]  R. Rothman,et al.  Serotonergic drugs and valvular heart disease , 2009, Expert opinion on drug safety.

[33]  P. Janak,et al.  Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption , 2005, The Journal of Neuroscience.

[34]  S. Halpain,et al.  The MAP2/Tau family of microtubule-associated proteins , 2004, Genome Biology.

[35]  Gabriele Vacun,et al.  Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. , 2003, Toxicology and applied pharmacology.

[36]  Christopher W. Jenks,et al.  Extraction Studies of Tabernanthe Iboga and Voacanga Africana , 2002, Natural product letters.

[37]  G. Feng,et al.  Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP , 2000, Neuron.

[38]  R. Rothman,et al.  Noribogaine (12‐Hydroxyibogamine): A Biologically Active Metabolite of the Antiaddictive Drug Ibogaine , 2000, Annals of the New York Academy of Sciences.

[39]  S. D. Glick,et al.  Total syntheses of racemic albifloranine and its anti-addictive congeners, including 18-methoxycoronaridine , 1999 .

[40]  S. D. Glick,et al.  18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats , 1996, Brain Research.

[41]  S. D. Glick,et al.  Tissue distribution of ibogaine after intraperitoneal and subcutaneous administration. , 1996, Life sciences.

[42]  J. N. Carlson,et al.  Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum , 1994, Brain Research.

[43]  J. Nunez.  Immature and mature variants of MAP2 and tau proteins and neuronal plasticity , 1988, Trends in Neurosciences.

[44]  R. Glennon,et al.  DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines. , 1983, European journal of pharmacology.

[45]  Paul A Wender,et al.  Function-oriented synthesis, step economy, and drug design. , 2008, Accounts of chemical research.

[46]  M. Westerfield.  The zebrafish book : a guide for the laboratory use of zebrafish (Danio rerio) , 1995 .