A Neural Network Approach for Predicting and Modelling the Dynamical Behaviour of Cardiac Ventricular Repolarisation

Physiological signals are usually patient specific, and they are difficult to predict, especially for the cardiovascular system. New methods capable to be adapted to each case and to learn the singular behavior of heart functions should be developed to support physicians in their decision-making. One of the most widely studied relations is the QT-RR one, between the total duration of the ventricle activation and inactivation, and the heart rate. In the past, different studies were made to approach this relation in the steady state. In this paper, a new method for modeling and predicting the transient dynamic behaviour of QT interval in relation to changing RR intervals is presented using artificial neural networks.

[1]  S. Ahnve,et al.  Correction of the QT interval for heart rate: review of different formulas and the use of Bazett's formula in myocardial infarction. , 1985, American heart journal.

[2]  C E Wraa,et al.  Effect of autonomic blockade on power spectrum of heart rate variability during exercise. , 1997, The American journal of physiology.

[3]  P Rubel,et al.  Methodology of ECG interpretation in the Lyon program. , 1990, Methods of information in medicine.

[4]  Geoffrey E. Hinton,et al.  Learning internal representations by error propagation , 1986 .

[5]  Arthur J. Moss,et al.  Noninvasive Electrocardiology: Clinical Aspects of Holter Monitoring , 1996 .

[6]  S. Chugh,et al.  Sudden cardiac death with apparently normal heart. , 2000, Circulation.

[7]  P. Schwartz,et al.  Gender and the relationship between ventricular repolarization and cardiac cycle length during 24-h Holter recordings. , 1997, European heart journal.

[8]  D. Escande,et al.  Steady‐State versus Non‐Steady‐State QT‐RR Relationships in 24‐hour Holter Recordings , 2000, Pacing and clinical electrophysiology : PACE.

[9]  J. Herlitz,et al.  The problem of out-of-hospital cardiac-arrest prevalence of sudden death in Europe today. , 1999, The American journal of cardiology.

[10]  J. Johnston,et al.  Left ventricular hypertrophy in hypertensive patients is associated with abnormal rate adaptation of QT interval. , 1997, Journal of the American College of Cardiology.

[11]  George Cybenko,et al.  Approximation by superpositions of a sigmoidal function , 1989, Math. Control. Signals Syst..

[12]  M. Messier,et al.  Predictive Factors of Ventricular Fibrillation Triggered by Pause‐Dependent Torsades de Pointes Associated with Acquired Long QT Interval: , 2000, Journal of cardiovascular electrophysiology.

[13]  F. Rengo,et al.  Influence of autonomic tone on QT interval duration. , 1997, Cardiologia.

[14]  P Rubel,et al.  CAVIAR: a serial ECG processing system for the comparative analysis of VCGs and their interpretation with auto-reference to the patient. , 1988, Journal of electrocardiology.

[15]  B Drew,et al.  Comparison of 18-lead ECG and selected body surface potential mapping leads in determining maximally deviated ST lead and efficacy in detecting acute myocardial ischemia during coronary occlusion. , 1999, Journal of electrocardiology.

[16]  P Rubel,et al.  New methods of quantitative assessment of the extent and significance of serial ECG changes of the repolarization phase. , 1988, Journal of electrocardiology.

[17]  B. Friedli Electrophysiological Follow-Up of Tetralogy of Fallot , 1999, Pediatric Cardiology.