Reduced colonization of gastric mucosa by Helicobacter pylori in mice deficient in interleukin‐101

Background and Aims: Interleukin‐10 (IL‐10) is a potent anti‐inflammatory and immunoregulatory cytokine. Mice deficient in IL‐10 production (IL‐10−/−mice) develop a spontaneous chronic enterocolitis, suggesting that IL‐10 is an important regulator of the mucosal immune response in vivo. The objective of this study was to determine the role of endogenous IL‐10 in the host defense against gastric colonization by Helicobacter pylori by using IL‐10‐deficient mice.

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