The gene for hepatocyte nuclear factor (HNF)‐4α is activated by glucocorticoids and glucagon, and repressed by insulin in rat liver

[1]  T. Sakmar,et al.  Two Cytoplasmic Loops of the Glucagon Receptor Are Required to Elevate cAMP or Intracellular Calcium* , 1999, The Journal of Biological Chemistry.

[2]  L. Groop,et al.  Mutation in the HNF-4alpha gene affects insulin secretion and triglyceride metabolism. , 1999, Diabetes.

[3]  M. Magnuson,et al.  Dual Roles for Glucokinase in Glucose Homeostasis as Determined by Liver and Pancreatic β Cell-specific Gene Knock-outs Using Cre Recombinase* , 1999, The Journal of Biological Chemistry.

[4]  A. M. Møller,et al.  A novel Phe75fsdelT mutation in the hepatocyte nuclear factor-4alpha gene in a Danish pedigree with maturity-onset diabetes of the young. , 1999, The Journal of clinical endocrinology and metabolism.

[5]  M. Takiguchi,et al.  Hypoglycemia-associated Hyperammonemia Caused by Impaired Expression of Ornithine Cycle Enzyme Genes in C/EBPα Knockout Mice* , 1998, The Journal of Biological Chemistry.

[6]  J. Bar-Tana,et al.  Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α , 1998, Nature.

[7]  P. Boutin,et al.  A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus. , 1998, The Journal of clinical investigation.

[8]  Hiroyuki Kuroki,et al.  Mutation in hepatocyte nuclear factor–1β gene (TCF2) associated with MODY , 1997, Nature Genetics.

[9]  M. Stoffel,et al.  The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[10]  M. J. Smith,et al.  Diminished Insulin and Glucagon Secretory Responses to Arginine in Nondiabetic Subjects With a Mutation in the Hepatocyte Nuclear Factor–4α/MODY1 Gene , 1997, Diabetes.

[11]  G. Bell,et al.  Organization and Partial Sequence of the Hepatocyte Nuclear Factor-4α/MODY1 Gene and Identification of a Missense Mutation, R127W, in a Japanese Family With MODY , 1997, Diabetes.

[12]  G. Bell,et al.  Maturity-Onset Diabetes of the Young Due to a Mutation in the Hepatocyte Nuclear Factor-4α Binding Site in the Promoter of the Hepatocyte Nuclear Factor-1α Gene , 1997, Diabetes.

[13]  W. Clarke,et al.  Early-onset type-ll diabetes mellitus (MODY4) linked to IPF1 , 1997, Nature Genetics.

[14]  G. Bell,et al.  Hepatic function in a family with a nonsense mutation (R154X) in the hepatocyte nuclear factor-4alpha/MODY1 gene. , 1997, The Journal of clinical investigation.

[15]  B. Viollet,et al.  Protein kinase A-dependent phosphorylation modulates DNA-binding activity of hepatocyte nuclear factor 4 , 1997, Molecular and cellular biology.

[16]  A. M. Møller,et al.  Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4α in Caucasians with maturity onset NIDDM , 1997, Diabetologia.

[17]  T. Frayling,et al.  A missense mutation in the hepatocyte nuclear factor 4 alpha gene in a UK pedigree with maturity-onset diabetes of the young , 1997, Diabetologia.

[18]  T. Hansen,et al.  Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3) , 1996, Nature.

[19]  M. Takiguchi,et al.  CCAAT/enhancer-binding protein beta (C/EBP beta) binds and activates while hepatocyte nuclear factor-4 (HNF-4) does not bind but represses the liver-type arginase promoter. , 1996, European journal of biochemistry.

[20]  M. Stoffel,et al.  Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1) , 1996, Nature.

[21]  M. Takiguchi,et al.  Transcriptional regulation of genes for ornithine cycle enzymes. , 1995, The Biochemical journal.

[22]  F. Sladek,et al.  The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[23]  J. Darnell,et al.  Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. , 1994, Genes & development.

[24]  M. Tulliez,et al.  Expression of the L-type pyruvate kinase gene and the hepatocyte nuclear factor 4 transcription factor in exocrine and endocrine pancreas. , 1994, The Journal of biological chemistry.

[25]  K. Yamamura,et al.  Determination of tissue specificity of the enhancer by combinatorial operation of tissue-enriched transcription factors. Both HNF-4 and C/EBP beta are required for liver-specific activity of the ornithine transcarbamylase enhancer. , 1994, The Journal of biological chemistry.

[26]  J. Beckmann,et al.  Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. , 1993, The New England journal of medicine.

[27]  L. G. Moss,et al.  Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[28]  T. Tsukamoto,et al.  A novel isoform of rat hepatocyte nuclear factor 4 (HNF-4). , 1992, Biochimica et biophysica acta.

[29]  J. Brosnan,et al.  Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans. , 1992, Physiological reviews.

[30]  G. Crabtree,et al.  A transcriptional hierarchy involved in mammalian cell-type specification , 1992, Nature.

[31]  S. Morris,et al.  Regulation of enzymes of urea and arginine synthesis. , 1992, Annual review of nutrition.

[32]  J. Darnell,et al.  Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. , 1990, Genes & development.

[33]  P. Ferré,et al.  Initial glucose kinetics and hormonal response to a gastric glucose load in unrestrained post-absorptive and starved rats. , 1990, The Biochemical journal.

[34]  K. Yamamoto,et al.  Functional dissection of the hormone and DNA binding activities of the glucocorticoid receptor. , 1987, EMBO Journal.

[35]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[36]  U. Schibler,et al.  Tissue-specific in vitro transcription from the mouse albumin promoter , 1986, Cell.

[37]  R. Evans,et al.  Functional domains of the human glucocorticoid receptor , 1986, Cell.

[38]  K. Tanaka,et al.  Biochemical studies on liver functions in primary cultured hepatocytes of adult rats. I. Hormonal effects on cell viability and protein synthesis. , 1978, Journal of biochemistry.

[39]  D. Friend,et al.  HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS , 1969, The Journal of cell biology.