论文信息 - Nonsensitized photoinduced destruction of tumor in experiments

Nonsensitized photoinduced destruction of tumor in experiments

The sizeable damage of tumor (Pliss lymphosarcoma) were detected on intact rats (without the photosensitizer injection) after laser excitation (λ=627.8 nm or λ=671 nm). The model is suggested to calculate the absolute and relative sizes of the tumor node necrosis and the area of the histotopographic section. The photon distribution between photosensitizer and hemoglobin molecules is calculated for the typical PDT conditions. We suppose that some non-photodynamic reactions activated by light are responsible for the observed photodestructive effect on intact tumors. The contribution of these reactions to the tumor damage in PDT treatments is considerable and it cannot be neglected.

[1] T. V. Oleinik,et al. The measurement of the absorption spectra of chlorine e6 photosensitizer and hemoglobin in whole blood by multiple light scattering , 2001 .

[2] E. Zhavrid,et al. Two‐Color Laser Photodynamic Therapy of Tumors , 2001 .

[3] M. E. Kenney,et al. Photothermal sensitization of amelanotic melanoma cells by Ni(II)-octabutoxy-naphthalocyanine. , 1999, Journal of photochemistry and photobiology. B, Biology.

[4] J D Spikes,et al. Photothermal sensitizers: possible use in tumor therapy. , 1990, Journal of photochemistry and photobiology. B, Biology.

[5] Arkady P. Ivanov,et al. Thermal action of a short light pulse on biological tissues , 2003 .

[6] P. Hynninen,et al. Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy. , 2004, Journal of photochemistry and photobiology. B, Biology.

[7] Raymond Bonnett,et al. Chemical Aspects of Photodynamic Therapy , 2000 .

[8] A. P. Ivanov,et al. Estimate of the Contribution of Localized Light Absorption by Blood Vessels to the Optical Properties of Biological tissue , 2004 .