Experimental and Analytical Investigation of a 2-D Magnetic Imaging Method Using Magnetic Nanoparticles

This paper deals with a magnetic imaging method of magnetic nanoparticles (MNPs). A complete analytical model is developed considering the main parameters of the system. Such analytical modeling of the magnetic induction generated in the space by the MNPs allows to describe the detection system performance and to consider the spatial reconstruction issue. In particular, for a given set of system parameters (sampling step, liftoff, and magnetic noise of the sensor), the ultimate spatial resolution in 2-D can be derived. We discuss the key parameters and compare the analytical model with the experimental data obtained from scanning measurement.

[1]  Frank Ludwig,et al.  Fluxgate based detection of magnetic nanoparticle dynamics in a rotating magnetic field , 2011 .

[2]  Basile Dufay,et al.  Impact of Electronic Conditioning on the Noise Performance of a Two-Port Network Giant MagnetoImpedance Magnetometer , 2011, IEEE Sensors Journal.

[3]  Frank Ludwig,et al.  Magnetorelaxometry of magnetic nanoparticles with fluxgate magnetometers for the analysis of biological targets , 2005 .

[4]  Q. Pankhurst,et al.  Applications of magnetic nanoparticles in biomedicine , 2003 .

[5]  K. Fodil,et al.  Dynamic Sensing of Magnetic Nanoparticles in Microchannel Using GMI Technology , 2013, IEEE Transactions on Magnetics.

[6]  Bradford G Orr,et al.  Development of a remanence measurement-based SQUID system with in-depth resolution for nanoparticle imaging , 2009, Physics in medicine and biology.

[7]  J Haueisen,et al.  Quantitative imaging of magnetic nanoparticles by magnetorelaxometry with multiple excitation coils , 2014, Physics in medicine and biology.

[8]  Ronald W. Davis,et al.  Detection of single micron-sized magnetic bead and magnetic nanoparticles using spin valve sensors for biological applications , 2003 .

[9]  Aggelos K. Katsaggelos,et al.  Digital image restoration , 2012, IEEE Signal Process. Mag..

[10]  Bo Zheng,et al.  Magnetic particle imaging (MPI) for NMR and MRI researchers. , 2013, Journal of magnetic resonance.

[11]  A. Kirsch.  An Introduction to the Mathematical Theory of Inverse Problems , 1996, Applied Mathematical Sciences.

[12]  Hugo Ferreira,et al.  Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: Biotechnological applications , 2002 .

[13]  K. Fodil,et al.  Model Calculation of the Magnetic Induction Generated by Magnetic Nanoparticles Flowing Into a Microfluidic System: Performance Analysis of the Detection , 2014, IEEE Transactions on Magnetics.

[14]  P. Freitas,et al.  Spintronic Biochips for Biomolecular Recognition , 2007 .

[15]  N. G. Sepulveda,et al.  Using a magnetometer to image a two‐dimensional current distribution , 1989 .

[16]  A. Lu,et al.  Magnetic nanoparticles: synthesis, protection, functionalization, and application. , 2007, Angewandte Chemie.

[17]  Relationship between spatial resolution and noise in scanning superconducting quantum interference device microscopy , 2002 .

[18]  John P. Wikswo,et al.  Reconstruction of two-dimensional magnetization and susceptibility distributions from the magnetic field of soft magnetic materials , 1996 .

[19]  K. Krishnan.  Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy , 2010, IEEE Transactions on Magnetics.

[20]  D. Bloyet,et al.  Spatial resolution of SQUID magnetometers and comparison with low noise room temperature magnetic sensors , 2002 .

[21]  K. Enpuku,et al.  Detection of magnetic nanoparticles with ac susceptibility measurement , 2004 .

[22]  P Jack Hoopes,et al.  Development of a magnetic nanoparticle susceptibility magnitude imaging array , 2014, Physics in medicine and biology.

[23]  Bernhard Gleich,et al.  Tomographic imaging using the nonlinear response of magnetic particles , 2005, Nature.

[24]  Zhiwei Zeng,et al.  Pulsed Eddy-Current Based Giant Magnetoresistive System for the Inspection of Aircraft Structures , 2010, IEEE Transactions on Magnetics.

[25]  Y. Tokura,et al.  LTS SQUID microscope with micron spatial resolution , 2003 .

[26]  Bernhard Gleich,et al.  Fundamentals and applications of magnetic particle imaging. , 2012, Journal of cardiovascular computed tomography.