Sleep Deprivation and Sustained Attention Performance: Integrating Mathematical and Cognitive Modeling

A long history of research has revealed many neurophysiological changes and concomitant behavioral impacts of sleep deprivation, sleep restriction, and circadian rhythms. Little research, however, has been conducted in the area of computational cognitive modeling to understand the information processing mechanisms through which neurobehavioral factors operate to produce degradations in human performance. Our approach to understanding this relationship is to link predictions of overall cognitive functioning, or alertness, from existing biomathematical models to information processing parameters in a cognitive architecture, leveraging the strengths from each to develop a more comprehensive explanation. The integration of these methodologies is used to account for changes in human performance on a sustained attention task across 88 h of total sleep deprivation. The integrated model captures changes due to time awake and circadian rhythms, and it also provides an account for underlying changes in the cognitive processes that give rise to those effects. The results show the potential for developing mechanistic accounts of how fatigue impacts cognition, and they illustrate the increased explanatory power that is possible by combining theoretical insights from multiple methodologies.

[1]  John R Anderson,et al.  An integrated theory of the mind. , 2004, Psychological review.

[2]  Laura A Stokowski.  Wake up to the importance of sleep. , 2005, Advances in neonatal care : official journal of the National Association of Neonatal Nurses.

[3]  H. L. Williams,et al.  Impaired performance with acute sleep loss. , 1959 .

[4]  David F. Dinges,et al.  Microcomputer analyses of performance on a portable, simple visual RT task during sustained operations , 1985 .

[5]  Charles A. Czeisler,et al.  The Timing of the Human Circadian Clock Is Accurately Represented by the Core Body Temperature Rhythm following Phase Shifts to a Three-Cycle Light Stimulus Near the Critical Zone , 2000, Journal of biological rhythms.

[6]  Frank E. Ritter,et al.  Techniques for modelling human performance in synthetic environments : A supplementary review , 1999 .

[7]  A. Kjellberg,et al.  Effects of 24-hour sleep deprivation on rate of decrement in a 10-minute auditory reaction time task. , 1972, Journal of experimental psychology.

[8]  N. Anderson,et al.  Effects of sleep deprivation on signal detection measures of vigilance: implications for sleep function. , 1983, Sleep.

[9]  S. Doran,et al.  Sustained attention performance during sleep deprivation: evidence of state instability. , 2001, Archives italiennes de biologie.

[10]  D. Dinges,et al.  Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability. , 2004, Sleep.

[11]  D. Dinges,et al.  Chapter 6 – Chronic Sleep Deprivation , 2005 .

[12]  K. Gluck,et al.  Understanding Decrements in Knowledge Access Resulting from Increased Fatigue , 2007 .

[13]  D. Dinges,et al.  Caffeine eliminates psychomotor vigilance deficits from sleep inertia. , 2001, Sleep.

[14]  Gregory G. Brown,et al.  The Effects of Total Sleep Deprivation on Cerebral Responses to Cognitive Performance , 2001, Neuropsychopharmacology.

[15]  M. Chee,et al.  Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation , 2004, The Journal of Neuroscience.

[16]  Mark C. Jones.  PRINCIPLES AND PRACTICE OF SLEEP MEDICINE , 1990 .

[17]  Glenn Gunzelmann,et al.  Using Computational Cognitive Modeling to Predict Dual-Task Performance With Sleep Deprivation , 2009, Hum. Factors.

[18]  K. Gluck,et al.  Neurobehaviorally Inspired ACT-R Model of Sleep Deprivation: Decreased Performance in Psychomotor Vigilance , 2006 .

[19]  P. Achermann.  The two-process model of sleep regulation revisited. , 2004, Aviation, space, and environmental medicine.

[20]  J. Horne,et al.  Vehicle accidents related to sleep: a review. , 1999, Occupational and environmental medicine.

[21]  N. Kleitman,et al.  STUDIES ON THE PHYSIOLOGY OF SLEEP: II. Attempts to Demonstrate Functional Changes in the Nervous System During Experimental Insomnia , 1923 .

[22]  Comparison of Mathematical Model Predictions to Experimental Data of Fatigue and Performance , 2004 .

[23]  D. Dinges,et al.  Psychomotor Vigilance Performance: Neurocognitive Assay Sensitive to Sleep Loss , 2004 .

[24]  C. Frith,et al.  A Specific Role for the Thalamus in Mediating the Interaction of Attention and Arousal in Humans , 1998, The Journal of Neuroscience.

[25]  J. Wolfe,et al.  PSYCHOLOGICAL SCIENCE Research Article SEARCHING NIGHT AND DAY: A Dissociation of Effects of Circadian Phase and Time Awake on Visual Selective Attention and Vigilance , 2022 .

[26]  A. Pettitt,et al.  High incentive effects on vigilance performance during 72 hours of total sleep deprivation. , 1985, Acta psychologica.

[27]  Maria L. Thomas,et al.  Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity , 2000, Journal of sleep research.

[28]  A. Newell.  Unified Theories of Cognition , 1990 .

[29]  D. Dinges,et al.  Neurocognitive consequences of sleep deprivation. , 2005, Seminars in neurology.

[30]  Johanna D. Moore.  Proceedings of the fifteenth annual meeting of the Cognitive Science Society , 1993 .

[31]  T. Balkin,et al.  Fatigue models for applied research in warfighting. , 2004, Aviation, space, and environmental medicine.

[32]  D. Bates,et al.  Effect of reducing interns' work hours on serious medical errors in intensive care units. , 2004, The New England journal of medicine.

[33]  David F Neri,et al.  Preface: Fatigue and Performance Modeling Workshop, June 13-14, 2002. , 2004, Aviation, space, and environmental medicine.

[34]  M. Buchsbaum,et al.  The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography. , 1991, Sleep.

[35]  Paolo Manganotti,et al.  Decrease in motor cortical excitability in human subjects after sleep deprivation , 2001, Neuroscience Letters.

[36]  K. Gluck,et al.  Individual Differences in Sustained Vigilant Attention: Insights from Computational Cognitive Modeling , 2008 .

[37]  Gregory G. Brown,et al.  Altered brain response to verbal learning following sleep deprivation , 2000, Nature.

[38]  J. Caldwell,et al.  The Effects of 37 Hours of Continuous Wakefulness On the Physiological Arousal, Cognitive Performance, Self-Reported Mood, and Simulator Flight Performance of F-117A Pilots , 2004 .

[39]  Gregory G. Brown,et al.  Increased cerebral response during a divided attention task following sleep deprivation , 2001, Journal of sleep research.

[40]  D. Dinges,et al.  Psychomotor Vigilance Performance: Neurocognitive Assay Sensitive to Sleep Loss , 2004 .

[41]  K. Gluck,et al.  Approaches to Modeling the Effects of Fatigue on Cognitive Performance , 2008 .

[42]  Richard E. Kronauer,et al.  Quantifying Human Circadian Pacemaker Response to Brief, Extended, and Repeated Light Stimuli over the Phototopic Range , 1999, Journal of biological rhythms.

[43]  John R. Anderson,et al.  A central circuit of the mind , 2008, Trends in Cognitive Sciences.

[44]  D. Dinges,et al.  The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. , 2003, Sleep.

[45]  Herbert Heuer,et al.  Total sleep deprivation increases the costs of shifting between simple cognitive tasks. , 2004, Acta psychologica.

[46]  D. Dinges,et al.  Catastrophes, sleep, and public policy: consensus report. , 1988, Sleep.

[47]  D. Dinges.  An overview of sleepiness and accidents , 1995, Journal of sleep research.

[48]  Rene J. de Pontbriand,et al.  Modeling Human Behavior with Integrated Cognitive Architectures: Comparison, Evaluation, and Validation Edited by Kevin A. Gluck & Richard A. Pew 2005, 440 pages, $55.00 Mahwah, NJ: Lawrence Erlbaum Associates ISBN 0-8058-5048-1 , 2007 .

[49]  Gregory G. Brown,et al.  Increasing task difficulty facilitates the cerebral compensatory response to total sleep deprivation. , 2004, Sleep.

[50]  G.M.G. Jongman.  Proceedings of the Second European Conference on Cognitive Modelling , 1998 .

[51]  Frank E. Ritter,et al.  The Rise of Cognitive Architectures , 2007, Integrated Models of Cognitive Systems.

[52]  D. Dinges,et al.  Chapter 6 – Chronic Sleep Deprivation , 2005 .

[53]  E. Zarahn,et al.  An event-related fMRI study of the neurobehavioral impact of sleep deprivation on performance of a delayed-match-to-sample task. , 2004, Brain research. Cognitive brain research.

[54]  R. Kronauer,et al.  Interactive Mathematical Models of Subjective Alertness and Cognitive Throughput in Humans , 1999, Journal of biological rhythms.

[55]  C. Lebiere,et al.  The Atomic Components of Thought , 1998 .

[56]  M. Chee,et al.  The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation , 2006, The Journal of Neuroscience.

[57]  Jon French,et al.  Modeling Fatigue Degraded Performance in Artificial Agents , 2003 .

[58]  D Royal.  National survey of distracted and drowsy driving attitudes and behaviors: 2002: volume 1: findings report , 2003 .

[59]  Hans P A Van Dongen.  Comparison of mathematical model predictions to experimental data of fatigue and performance. , 2004, Aviation, space, and environmental medicine.

[60]  D. Dinges,et al.  Summary of the key features of seven biomathematical models of human fatigue and performance. , 2004, Aviation, space, and environmental medicine.

[61]  Roman V. Belavkin.  Modelling the Inverted-U Effect with Act-r , 2002 .

[62]  D Royal,et al.  VOLUME I: FINDINGS -- NATIONAL SURVEY OF DISTRACTED AND DROWSY DRIVING ATTITUDES AND BEHAVIORS: 2002 , 2003 .

[63]  G. Miller,et al.  Cognitive science. , 1981, Science.

[64]  E. Brown,et al.  The parathyroid hormone circadian rhythm is truly endogenous--a general clinical research center study. , 1997, The Journal of clinical endocrinology and metabolism.

[65]  G.M.G. Jongman,et al.  How to fatigue ACT-R? , 1998 .

[66]  Richard E. Kronauer,et al.  Erratum: Quantifying human circadian pacemaker response to brief, extended, and repeated light stimuli over the photopic range (Journal of Biological Rhythms) , 2000 .

[67]  M. Kryger,et al.  Principles and Practice of Sleep Medicine , 1989 .

[68]  C. J. McGrath,et al.  Effect of exchange rate return on volatility spill-over across trading regions , 2012 .

[69]  Rolf Ulrich,et al.  Central Slowing During the Night , 2007, Psychological science.

[70]  Andrew M. Pack,et al.  Characteristics of crashes attributed to the driver having fallen asleep. , 1995, Accident; analysis and prevention.

[71]  Thomas A. Dingus,et al.  The Impact of Driver Inattention on Near-Crash/Crash Risk: An Analysis Using the 100-Car Naturalistic Driving Study Data , 2006 .

[72]  P. Achermann,et al.  Sleep Homeostasis and Models of Sleep Regulation , 1999 .

[73]  Wayne D. Gray.  Integrated Models of Cognitive Systems , 2007, Oxford series on cognitive models and architectures.

[74]  D. Dinges,et al.  Performing while sleepy: Effects of experimentally-induced sleepiness. , 1991 .

[75]  Elizabeth B. Klerman,et al.  Review: On Mathematical Modeling of Circadian Rhythms, Performance, and Alertness , 2007, Journal of biological rhythms.

[76]  A. Kjellberg.  Sleep deprivation and some aspects of performance: ii. Lapses and other attentional effects , 1977 .

[77]  D. Dinges,et al.  Sleep, circadian rhythms, and psychomotor vigilance. , 2005, Clinics in sports medicine.