Quantitative analysis of the alveolar plateau in the diagnosis of early airway obstruction.

A modified single-breath nitrogen test was used in an emphysema screening center to assess the value of the analysis of the alveolar plateau in the early diagnosis of airway obstruction. Predicted values for the slope of the alveolar plateau (the increase in nitrogen concentration per 1,000 ml) were first constructed using a population of 134 nonsmoking males and 203 nonsmoking females. Data obtained from 530 cigarette smokers attending the screening center were then compared with these predicted values and with predicted values for closing volume, expressed as a percentage of vital capacity, and closing capacity, expressed as a percentage of total lung capacity, derived from virtually the same population of nonsmoking adults. Of the cigarette smokers, 47 per cent had abnormal slope of the alveolar plateau, 44 per cent had an abnormal ratio of closing capacity to total lung capacity, 35 per cent had an abnormal ratio of closing volume to vital capacity, and 11 per cent had an abnormal forced expiratory vo...

[1]  B. B. Ross,et al.  Predicted values for closing volumes using a modified single breath nitrogen test. , 2015, The American review of respiratory disease.

[2]  B. B. Ross,et al.  A comparison of conventional spirometric tests and the test of closing volume in an emphysema screening center. , 1973, The American review of respiratory disease.

[3]  P. Macklem.  Obstruction in small airways--a challenge to medicine. , 1972, The American journal of medicine.

[4]  J Milic-Emili,et al.  Measurement of "closing volume" as a simple and sensitive test for early detection of small airway disease. , 1972, The American journal of medicine.

[5]  J. Plummer,et al.  The prevalence of chronic bronchitis, chronic airway obstruction, and respiratory symptoms in a Colorado city. , 1971, The American review of respiratory disease.

[6]  N. Anthonisen,et al.  Gravity-depende sequential emptying of lung regions. , 1970, Journal of applied physiology.

[7]  N. Anthonisen,et al.  Airway closure as a function of age. , 1969, Respiration physiology.

[8]  P. Macklem,et al.  Frequency dependence of compliance as a test for obstruction in the small airways. , 1969, The Journal of clinical investigation.

[9]  N. Anthonisen,et al.  Regional lung function in patients with chronic bronchitis. , 1968, Clinical science.

[10]  J. Hogg,et al.  Site and nature of airway obstruction in chronic obstructive lung disease. , 1968, The New England journal of medicine.

[11]  J. Jones,et al.  The influence of gaseous diffusion on the alveolar plateau at different lung volumes. , 1967, Respiration physiology.

[12]  E. Berglund,et al.  Airways Obstruction and Uneven Gas Distribution in the Lung , 1963, Thorax.

[13]  R. S. Gaines,et al.  A survey for chronic respiratory disease in an industrial city. Preliminary results. , 1962, The American review of respiratory disease.

[14]  B. Ferris,et al.  The prevalence of chronic respiratory disease in a New Hampshire town. , 1962, The American review of respiratory disease.

[15]  W. S. Fowler.  Lung function studies; uneven pulmonary ventilation in normal subjects and in patients with pulmonary disease. , 1949, Journal of applied physiology.

[16]  K. Prowse,et al.  Effects of lung volume and disease on the lung nitrogen decay curve. , 1973, Journal of applied physiology.

[17]  D. Teculescu,et al.  Reproducibility and normal values of the single breath nitrogen test. , 1968, Scandinavian journal of respiratory diseases.

[18]  I. Kjellmer,et al.  Alveolar plateau of the single breath nitrogen elimination curve in normal subjects. , 1959, Journal of applied physiology.

[19]  J. Mead,et al.  Mechanical factors in distribution of pulmonary ventilation. , 1956, Journal of applied physiology.

[20]  W. S. Fowler.  Intrapulmonary distribution of inspired gas. , 1952, Physiological reviews.