Effects of IGFBP-2 overexpression in vitro and in vivo

[1]  J. Kratzsch,et al.  Regulation of growth hormone (GH), insulin-like growth factor (IGF)I, IGF binding proteins -1, -2, -3 and GH binding protein during progression of liver cirrhosis. , 2009, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

[2]  A. Hoeflich,et al.  Overexpression of insulin-like growth factor-binding protein-2 results in increased tumorigenic potential in Y-1 adrenocortical tumor cells. , 2000, Cancer research.

[3]  A. Sidawy,et al.  Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers. , 1998, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[4]  E. Wolf,et al.  Insulin‐like growth factor‐binding protein‐2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF‐responsive colon carcinoma cell lines , 1998, FEBS letters.

[5]  S. Khosla,et al.  Insulin-Like Growth Factor System Abnormalities in Hepatitis C-Associated Osteosclerosis , 1998 .

[6]  M. Spiteri,et al.  Expression of insulin-like growth factor binding proteins in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis. , 1998, American journal of respiratory cell and molecular biology.

[7]  P. Lønning,et al.  Influence of treatment with onapristone on the IGF-system in breast cancer patients , 1998, The Journal of Steroid Biochemistry and Molecular Biology.

[8]  S. Corroyer,et al.  Expression of insulin-like growth factors and their binding proteins by bronchoalveolar cells from children with and without interstitial lung disease. , 1998, The European respiratory journal.

[9]  S. Adler,et al.  Insulin-like growth factor system and the kidney: physiology, pathophysiology, and therapeutic implications. , 1998, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[10]  S. Khosla,et al.  Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults. , 1998, The Journal of clinical investigation.

[11]  P. O'neill,et al.  The diagnosis of severe growth hormone deficiency in elderly patients with hypothalamic–pituitary disease , 1998, Clinical endocrinology.

[12]  A. Hoeflich,et al.  Altered growth of mice divergently selected for body weight is associated with complex changes in the growth hormone/insulin-like growth factor system. , 1998, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.

[13]  C. Peter,et al.  Pharmacological and Toxicological Effects of Chronic Porcine Growth Hormone Administration in Dogs , 1998, Toxicologic pathology.

[14]  P. Crossey,et al.  Hepatic growth hormone receptor, insulin‐like growth factor I, and insulin‐like growth factor‐binding protein messenger RNA expression in pediatric liver disease , 1997, Hepatology.

[15]  G. Brem,et al.  Interactions of insulin-like growth factor (IGF)-II and growth hormone in vivo: circulating levels of IGF-I and IGF-binding proteins in transgenic mice. , 1997, European journal of endocrinology.

[16]  S. Mohan,et al.  Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. , 1997, Endocrine reviews.

[17]  Rohan M. Lewis,et al.  Perinatal Growth Disturbance in the Spontaneously Hypertensive Rat , 1997, Pediatric Research.

[18]  G. Werther,et al.  Insulin-like growth factor binding protein-2 binds to cell surface proteoglycans in the rat brain olfactory bulb. , 1997, Endocrinology.

[19]  A. Flyvbjerg Role of growth hormone, insulin-like growth factors (IGFs) and IGF-binding proteins in the renal complications of diabetes. , 1997, Kidney international. Supplement.

[20]  O. S. Nielsen,et al.  Elevated serum insulin-like growth factor-binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: correlation with cancer antigen 125 and tumor-associated trypsin inhibitor. , 1997, The Journal of clinical endocrinology and metabolism.

[21]  D. Hill,et al.  Spatial and temporal changes in the insulin-like growth factor (IGF) axis indicate autocrine/paracrine actions of IGF-I within wounds of the rat brain. , 1997, Endocrinology.

[22]  M. Phillip,et al.  Renal hypertrophy in hyperglycemic non-obese diabetic mice is associated with persistent renal accumulation of insulin-like growth factor I. , 1997, Journal of the American Society of Nephrology : JASN.

[23]  B. Tönshoff,et al.  Derangements of the somatotropic hormone axis in chronic renal failure. , 1997, Kidney international. Supplement.

[24]  M. Binoux,et al.  Role of Insulin-Like Growth Factor Binding Protein-2 and Its Limited Proteolysis in Neuroblastoma Cell Proliferation: Modulation by Transforming Growth Factor-β and Retinoic Acid. , 1997, Endocrinology.

[25]  A. Hoeflich,et al.  Expression of IGFBP-2, -3, and -4 mRNA during differentiation of Caco-2 colon epithelial cells. , 1996, The American journal of physiology.

[26]  J. Kopchick,et al.  A growth hormone antagonist protects mice against streptozotocin induced glomerulosclerosis even in the presence of elevated levels of glucose and glycated hemoglobin. , 1996, Endocrinology.

[27]  K. Brismar,et al.  Decreased bioavailability of insulin-like growth factor-I, a cause of catabolism in hemodialysis patients? , 1996, Growth regulation.

[28]  Xin Zhao,et al.  Inhibition of cellular proliferation and modulation of insulin‐like growth factor binding proteins by retinoids in a bovine mammary epithelial cell line , 1996, Journal of cellular physiology.

[29]  V. Preedy,et al.  Differential effects of malnutrition, bile duct ligation and galactosamine injection in young rats on serum levels and gene expression of IGF-binding proteins. , 1996, The Journal of endocrinology.

[30]  B. Ryffel,et al.  Growth inhibition signalled through the interleukin-4/interleukin-13 receptor complex is associated with tyrosine phosphorylation of insulin receptor substrate-1. , 1996, The Biochemical journal.

[31]  J. Holly,et al.  Expression of IGF-I and IGF-binding protein genes in cirrhotic liver. , 1996, The Journal of endocrinology.

[32]  E. Wolf,et al.  Physiology and pathology of growth — studies in GH transgenic mice , 1996 .

[33]  B. Seetharam,et al.  Expression of IGF-II and IGF binding proteins in differentiating human intestinal Caco-2 cells. , 1995, The American journal of physiology.

[34]  A. Evan,et al.  Analysis of insulin-like growth factors (IGF)-I, and -II, type II IGF receptor and IGF-binding protein-2 mRNA and peptide levels in normal and nephrectomized rat kidney. , 1995, Kidney international.

[35]  C. Ohlsson,et al.  Insulin-like growth factor binding proteins-2 and -3 stimulate growth hormone receptor binding and mitogenesis in rat osteosarcoma cells. , 1995, Endocrinology.

[36]  D. Clemmons,et al.  Insulin-like growth factor (IGF)-binding proteins inhibit the smooth muscle cell migration responses to IGF-I and IGF-II. , 1995, Endocrinology.

[37]  S. Adler,et al.  Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen. , 1995, Kidney international.

[38]  M. Corkins,et al.  Growth stimulation by transfection of intestinal epithelial cells with an antisense insulin-like growth factor binding protein-2 construct. , 1995, Biochemical and biophysical research communications.

[39]  Schreiber Bd,et al.  Insulin-like growth factor-1 stimulates production of mesangial cell matrix components. , 1995 .

[40]  R. Rosenfeld,et al.  Alteration in insulin-like growth factor-binding proteins (IGFBPs) and IGFBP-3 protease activity in serum and urine from acute and chronic renal failure. , 1994, The Journal of clinical endocrinology and metabolism.

[41]  E. Wolf,et al.  Consequences of postnatally elevated insulin-like growth factor-II in transgenic mice: endocrine changes and effects on body and organ growth. , 1994, Endocrinology.

[42]  F. Garrouste,et al.  Alterations in serum levels of insulin‐like growth factors and insulin‐like growth‐factor‐binding proteins in patients with colorectal cancer , 1994, International journal of cancer.

[43]  M. Kitamura,et al.  The effect of selective growth hormone defect in the progression of glomerulosclerosis. , 1994, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[44]  Z. Shao,et al.  Insulin‐like growth factor‐binding protein enhancement of insulin‐like growth factor‐i (IGF‐I)–mediated DNA synthesis and IGF‐I binding in a human breast carcinoma cell line , 1994, Journal of cellular physiology.

[45]  H. Freyberger,et al.  Vitreous levels of the insulin-like growth factors I and II, and the insulin-like growth factor binding proteins 2 and 3, increase in neovascular eye disease. Studies in nondiabetic and diabetic subjects. , 1993, The Journal of clinical investigation.

[46]  N. Bleehen,et al.  Role for membrane and secreted insulin-like growth factor-binding protein-2 in the regulation of insulin-like growth factor action in lung tumors. , 1993, Cancer research.

[47]  M. Papa,et al.  Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigen. , 1993, The Journal of clinical endocrinology and metabolism.

[48]  T. Unterman,et al.  Maternal Hypoxia as a Model for Intrauterine Growth Retardation: Effects on Insulin-Like Growth Factors and Their Binding Proteins , 1993, Pediatric Research.

[49]  R. Wanke,et al.  Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: Lessons from transgenic animal models , 1993, Mechanisms of Ageing and Development.

[50]  M. Ranke,et al.  Clinical studies of IGFBP-2 by radioimmunoassay. , 1993, Growth regulation.

[51]  T. Wood,et al.  Targeted disruption of IGFBP-2 gene. , 1993, Growth regulation.

[52]  C. Roberts,et al.  Insulin-like growth factor-I (IGF-I) and retinoic acid modulation of IGF-binding proteins (IGFBPs): IGFBP-2, -3, and -4 gene expression and protein secretion in a breast cancer cell line. , 1992, Endocrinology.

[53]  R. McCusker,et al.  Secretion of insulin-like growth factor II (IGF-II) and IGF-binding protein-2 by intestinal epithelial (IEC-6) cells: implications for autocrine growth regulation. , 1992, Endocrinology.

[54]  D. B. Evans,et al.  Recombinant human [Cys281]insulin-like growth factor-binding protein 2 inhibits both basal and insulin-like growth factor I-stimulated proliferation and collagen synthesis in fetal rat calvariae. , 1991, The Journal of biological chemistry.

[55]  D. Hill,et al.  Hormonal regulation of insulin-like growth factor (IGF)-binding proteins secreted by isolated sheep thyroid epithelial cells: relationship with iodine organification. , 1991, The Journal of endocrinology.

[56]  A. M. Nahas The role of growth hormone and insulin-like growth factor-I in experimental renal growth and scarring. , 1991 .

[57]  G. Striker,et al.  Mesangial cell turnover: effect of heparin and peptide growth factors. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[58]  G. Striker,et al.  Glomerular lesions in mice transgenic for growth hormone and insulinlike growth factor-I. I. Relationship between increased glomerular size and mesangial sclerosis. , 1990, The American journal of pathology.

[59]  L. Fine,et al.  Renal hypertrophy, growth factors, and nephropathy in diabetes mellitus. , 1990, Seminars in nephrology.

[60]  E. Wolf,et al.  Multiple consequences of human growth hormone expression in transgenic mice. , 1989, Molecular biology & medicine.

[61]  C. R. Betts,et al.  Dual regulation of insulin-like growth factor I expression during renal hypertrophy. , 1989, The American journal of physiology.

[62]  R. Palmiter,et al.  Growth enhancement of transgenic mice expressing human insulin-like growth factor I. , 1988, Endocrinology.

[63]  A. Hoeflich,et al.  Overexpression of insulin-like growth factor-binding protein-2 in transgenic mice reduces postnatal body weight gain. , 1999, Endocrinology.

[64]  M. Binoux,et al.  Role of insulin-like growth factor binding protein-2 and its limited proteolysis in neuroblastoma cell proliferation: modulation by transforming growth factor-beta and retinoic acid. , 1997, Endocrinology.

[65]  M. Langman,et al.  Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers. , 1997, British Journal of Cancer.

[66]  E. Wolf,et al.  Human insulin-like growth factor I (IGF-I) produced in the mammary glands of transgenic rabbits: yield, receptor binding, mitogenic activity, and effects on IGF-binding proteins. , 1997, Endocrinology.

[67]  V. Han,et al.  Insulin-like growth factor (IGF) and IGF binding protein gene expression in multicystic renal dysplasia. , 1997, Journal of the American Society of Nephrology : JASN.

[68]  R. Holt,et al.  Sequential changes in insulin-like growth factor I (IGF-I) and IGF-binding proteins in children with end-stage liver disease before and after successful orthotopic liver transplantation. , 1996, The Journal of clinical endocrinology and metabolism.

[69]  J. Thrasher,et al.  Insulin-like growth factor-binding protein-2 and -3 expression in benign human prostate epithelium, prostate intraepithelial neoplasia, and adenocarcinoma of the prostate. , 1996, The Journal of clinical endocrinology and metabolism.

[70]  V. Cazals,et al.  Glucocorticoid-induced growth arrest of lung alveolar epithelial cells is associated with increased production of insulin-like growth factor binding protein-2. , 1996, Endocrinology.

[71]  J. Rosen,et al.  Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression. , 1996, Endocrinology.

[72]  T. Wood,et al.  Genetic approaches to the function of insulin-like growth factor-binding proteins during rodent development. , 1996, Hormone research.

[73]  J. Pintar,et al.  Genetic ablation of IGFBP-2 suggests functional redundancy in the IGFBP family. , 1995, Progress in growth factor research.

[74]  B. Schreiber,et al.  Insulin-like growth factor-1 stimulates production of mesangial cell matrix components. , 1995, Clinical nephrology.

[75]  B. Tönshoff,et al.  Insulin-like growth factors (IGF) and IGF binding proteins in children with chronic renal failure. , 1995, Progress in Growth Factor Research.

[76]  V. Han,et al.  The expression of insulin-like growth factor (IGF)-binding protein-2 and IGF-II genes in the tissues of the developing ovine fetus. , 1993, Endocrinology.

[77]  E. Wolf,et al.  The GH-transgenic mouse as an experimental model for growth research: clinical and pathological studies. , 1992, Hormone research.

[78]  R. Goya,et al.  Plasma levels of growth hormone correlate with the severity of pathologic changes in the renal structure of aging rats. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[79]  A. E. El Nahas The role of growth hormone and insulin-like growth factor-I in experimental renal growth and scarring. , 1991, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[80]  C. Hagen,et al.  Insulinlike Growth Factor Binding Proteins , 1990 .

[81]  R. Palmiter,et al.  Histopathology associated with elevated levels of growth hormone and insulin-like growth factor I in transgenic mice. , 1989, Endocrinology.

[82]  R. Palmiter,et al.  Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1. , 1988, The American journal of pathology.