Bone-marrow transplantation for severe aplastic anaemia using histocompatible unrelated volunteer donors.

Two patients with severe aplastic anaemia received bone-marrow transplants from unrelated donors selected for HLA compatibility. Graft-versus-host disease occurred in both patients but responded to treatment. Both patients had stormy courses after grafting, but subsequently their conditions improved, and one was not receiving any treatment at follow-up after day 330 while the other had mild chronic graft-versus-host disease at day 150. These results show that unrelated, histocompatible volunteers may successfully donate marrow for the treatment of severe aplastic anaemia, though many problems remain to be solved.

[1]  E. Gordon-Smith,et al.  USE OF CYCLOSPORIN A IN ALLOGENEIC BONE MARROW TRANSPLANTATION FOR SEVERE APLASTIC ANEMIA , 1982, Transplantation.

[2]  C. Dearden,et al.  SERUM LEVELS OF CYCLOSPORIN A AND NEPHROTOXICITY IN BONE MARROW TRANSPLANT PATIENTS , 1981, The Lancet.

[3]  A. Gratwohl,et al.  Treatment of severe aplastic anaemia with antilymphocyte globulin or bone-marrow transplantation. , 1981, British medical journal.

[4]  A. Carella,et al.  Severe Aplastic Anaemia: Correlation of in Vitro Tests with Clinical Response to Immunosuppression in 20 Patients , 1981, British journal of haematology.

[5]  R. Storb,et al.  Transplantation of marrow from an unrelated donor to a patient with acute leukemia. , 1980, The New England journal of medicine.

[6]  K. Welsh,et al.  HLA-DR antigens and toxic reaction to sodium aurothiomalate and D-penicillamine in patients with rheumatoid arthritis. , 1980, The New England journal of medicine.

[7]  B. Darlow,et al.  Bone marrow transplantation for severe aplastic anaemia. , 1980, The New Zealand medical journal.

[8]  R. Storb,et al.  VARICELLA‐ZOSTER VIRUS INFECTION AFTER MARROW TRANSPLANTATION FOR APLASTIC ANEMIA OR LEUKEMIA , 1980, Transplantation.

[9]  R. Storb,et al.  Marrow transplantation for treatment of aplastic anaemia. , 1978, Clinics in haematology.

[10]  Uclabonemarrowtransplantte.  BONE-MARROW TRANSPLANTATION IN SEVERE APLASTIC ANqMIA , 1976 .

[11]  R. Storb,et al.  Severe aplastic anemia: a prospective study of the effect of early marrow transplantation on acute mortality. , 1976, Blood.

[12]  M. Beard,et al.  Bone-marrow transplantation in severe aplastic anaemia. , 1976, Lancet.

[13]  B. Speck,et al.  Allogeneic bone marrow transplantation in a patient with aplastic anemia using a phenotypically HL-A-identifcal unrelated donor. , 1973, Transplantation.

[14]  P. Terasaki,et al.  A SEMIMICRO MIXED LEUKOCYTE CULTURE TEST , 1971, Transplantation.