Synthesis of heterocycle-modified betulinic acid derivatives as antitumor agents.
暂无分享,去创建一个
W. Gao | Mingyao Liu | Yuan He | Xue Wang | Z. Yi | M. Qin | Wen-Wei Qiu | Ting Liu | Cheng Gao | Hai-Wei Cui | Jinhua Wang | Yan Wang
[1] Q. Tan,et al. Evodiamine Induces G2/M Arrest and Apoptosis via Mitochondrial and Endoplasmic Reticulum Pathways in H446 and H1688 Human Small-Cell Lung Cancer Cells , 2014, PloS one.
[2] M. D’hooghe,et al. Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates. , 2014, Bioorganic & medicinal chemistry letters.
[3] Yuan He,et al. Synthesis of Novel Heterocyclic Ring‐Fused 18β‐Glycyrrhetinic Acid Derivatives with Antitumor and Antimetastatic Activity , 2014, Chemical biology & drug design.
[4] R. Csuk. Betulinic acid and its derivatives: a patent review (2008 – 2013) , 2014, Expert opinion on therapeutic patents.
[5] Mingyao Liu,et al. Optimization of 2-(3-(arylalkyl amino carbonyl) phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives as potent antitumor growth and metastasis agents. , 2014, European journal of medicinal chemistry.
[6] Daniel J. Emmerich,et al. Synthesis and studies of anticancer properties of lupane-type triterpenoid derivatives containing a cisplatin fragment. , 2014, European journal of medicinal chemistry.
[7] M. Hajdúch,et al. Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid. , 2012, Bioorganic & medicinal chemistry.
[8] Mingyao Liu,et al. Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption. , 2012, Journal of medicinal chemistry.
[9] S. Safe,et al. Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors , 2011, BMC Cancer.
[10] D. Ströhl,et al. Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid. , 2010, European journal of medicinal chemistry.
[11] Jia Li,et al. Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. , 2009, Bioorganic & medicinal chemistry letters.
[12] J. Thorson,et al. Enhancing the divergent activities of betulinic acid via neoglycosylation. , 2009, Organic letters.
[13] S. Shukla,et al. Betulinic acid suppresses constitutive and TNFα‐induced NF‐κB activation and induces apoptosis in human prostate carcinoma PC‐3 cells , 2008, Molecular carcinogenesis.
[14] Yusuke Yamamoto,et al. RPN2 gene confers docetaxel resistance in breast cancer , 2008, Nature Medicine.
[15] R. Freshney. ZD6474 reverses multidrug resistance by directly inhibiting the function of P-glycoprotein , 2007, British Journal of Cancer.
[16] J. Medema,et al. Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types. , 2007, Cancer letters.
[17] W. Lee,et al. Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ. , 2006, Biological & pharmaceutical bulletin.
[18] Perumal Yogeeswari,et al. Betulinic acid and its derivatives: a review on their biological properties. , 2005, Current medicinal chemistry.
[19] I. Jeremias,et al. Betulinic acid-induced apoptosis in leukemia cells , 2004, Leukemia.
[20] R. Supino,et al. Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells. , 2002, Cancer letters.
[21] J. Eberle,et al. The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis. , 2001, The Journal of investigative dermatology.
[22] J. Slupsky,et al. Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha. , 2000, Molecular pharmacology.
[23] I. Jeremias,et al. Betulinic acid: A new cytotoxic agent against malignant brain‐tumor cells , 1999, International journal of cancer.
[24] I. Jeremias,et al. Betulinic acid: a new chemotherapeutic agent in the treatment of neuroectodermal tumors , 1999, Klinische Padiatrie.
[25] J. Dichgans,et al. Betulinic acid-induced apoptosis in glioma cells: A sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. , 1999, The Journal of pharmacology and experimental therapeutics.
[26] M. Peter,et al. Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid* , 1998, The Journal of Biological Chemistry.
[27] K. Lee,et al. Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives. , 1997, Bioorganic & medicinal chemistry.
[28] Geoffrey A. Cordell,et al. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis , 1995, Nature Medicine.
[29] M. Bentley,et al. Betulin and lupeol in bark from four white-barked birches , 1988 .