Cardioventilatory coupling in heart rate variability: methods for qualitative and quantitative determination.

In this study we sought to develop quantitative methods for determining the presence of cardioventilatory coupling in raw heart rate time series. The beat-to-beat RR interval time series of 98 anaesthetized, spontaneously breathing subjects were represented graphically as (1) raw RR interval time series, (2) RR consecutive difference time series and (3) a phase portrait of the RR consecutive difference time series. We then examined the relationships between the presence of cardioventilatory coupling in these epochs and the plot appearance and entropy measures derived from these plots. We observed that coupling was significantly associated with the presence of banding in the raw heart rate and RR consecutive difference time series, and with discrete clustering within the RR consecutive difference phase portrait. A significant correlation was found between coupling and the entropy of the RR consecutive difference time series and its phase portrait. We conclude that, with some provisos, these simple graphical and derived quantitative measures provide a basis for the determination of cardioventilatory coupling from heart rate time series.

[1]  P. Larsen,et al.  Cardioventilatory coupling in atrial fibrillation. , 1999, British journal of anaesthesia.

[2]  D L Eckberg,et al.  Human sinus arrhythmia as an index of vagal cardiac outflow. , 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

[3]  P. Larsen,et al.  Ventilatory frequency variability in spontaneously breathing anaesthetized subjects. , 1999, British journal of anaesthesia.

[4]  P. Larsen,et al.  Cardioventilatory coupling: effects of IPPV. , 1999, British journal of anaesthesia.

[5]  P. Larsen,et al.  Cardioventilatory coupling in heart rate variability: the value of standard analytical techniques. , 2001, British journal of anaesthesia.

[6]  J. Hirsch,et al.  Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate. , 1981, The American journal of physiology.

[7]  D. Galletly,et al.  Inspiratory timing during anaesthesia: a model of cardioventilatory coupling. , 2001, British journal of anaesthesia.

[8]  P. Larsen,et al.  The determination of cardioventilatory coupling from heart rate and ventilatory time series , 1999, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.

[9]  P. Larsen,et al.  Cardioventilatory coupling during anaesthesia. , 1997, British journal of anaesthesia.

[10]  P. Larsen,et al.  Relationship between cardioventilatory coupling and respiratory sinus arrhythmia. , 1998, British journal of anaesthesia.