A Gradient Rule for the Plasticity of a Neuron's Intrinsic Excitability

While synaptic learning mechanisms have always been a core topic of neural computation research, there has been relatively little work on intrinsic learning processes, which change a neuron’s excitability. Here, we study a single, continuous activation model neuron and derive a gradient rule for the intrinsic plasticity based on information theory that allows the neuron to bring its firing rate distribution into an approximately exponential regime, as observed in visual cortical neurons. In simulations, we show that the rule works efficiently.

[1]  Terrence J. Sejnowski,et al.  An Information-Maximization Approach to Blind Separation and Blind Deconvolution , 1995, Neural Computation.

[2]  E Marder,et al.  Memory from the dynamics of intrinsic membrane currents. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[3]  L. Abbott,et al.  Responses of neurons in primary and inferior temporal visual cortices to natural scenes , 1997, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[4]  Niraj S. Desai,et al.  Plasticity in the intrinsic excitability of cortical pyramidal neurons , 1999, Nature Neuroscience.

[5]  Christof Koch,et al.  How voltage-dependent conductances can adapt to maximize the information encoded by neuronal firing rate , 1999, Nature Neuroscience.

[6]  D. Debanne,et al.  Long-term plasticity of intrinsic excitability: learning rules and mechanisms. , 2003, Learning & memory.

[7]  D. Linden,et al.  The other side of the engram: experience-driven changes in neuronal intrinsic excitability , 2003, Nature Reviews Neuroscience.

[8]  Robert H. Cudmore,et al.  Long-term potentiation of intrinsic excitability in LV visual cortical neurons. , 2004, Journal of neurophysiology.

[9]  Jochen Triesch,et al.  Synergies between Intrinsic and Synaptic Plasticity in Individual Model Neurons , 2004, NIPS.

[10]  Mei Zhang,et al.  Calcium signal-dependent plasticity of neuronal excitability developed postnatally. , 2004, Journal of neurobiology.